인터루킨-6 수용체
Interleukin-6 receptor
CD126(Cluster of Dividation 126)로도 알려진 인터루킨 6 수용체(IL6R)는 I형 사이토카인 수용체다.
함수
인터루킨6(IL6)는 세포 성장과 분화를 조절하는 강력한 플리토킨으로 면역 반응에 중요한 역할을 한다.IL6와 이 수용체의 조절불능 생산은 다발성 골수종, 자가면역질환, 전립선암 등 많은 질병의 병원생식에 관여한다.
멜라노사이트에서 IL6R 유전자 발현은 MITF에 의해 조절될 수 있다.[5]
구조
IL6 수용체는 IL-6 수용체 서브유닛(IL6R)과 인터루킨 6 신호 변환기 글리코프로틴 130으로 구성된 단백질 복합체다.IL6R은 또한 이 서브 유닛을 인코딩하는 인간 유전자를 나타낸다.또는 구별되는 ISO 양식을 인코딩하는 분할된 대본 변형이 보고되었다.[6]IL6R 서브유닛은 또한 많은 다른 사이토카인들에 의해 공유된다.
상호작용
인터루킨-6 수용체는 인터루킨 6[7][8][9] 및 담도 신경영양인자와 상호작용하는 것으로 나타났다.[8][10]
참고 항목
- 분화 클러스터
- 반일-6
- Tocilizumab, IL6R에 대한 단일 클론 항체
- 사릴루맵, IL6R에 대한 단클론 항체
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000160712 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000027947 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
- ^ "Entrez Gene: IL6R interleukin 6 receptor".
- ^ Schwantner A, Dingley AJ, Ozbek S, Rose-John S, Grötzinger J (Jan 2004). "Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy". J. Biol. Chem. 279 (1): 571–6. doi:10.1074/jbc.M311019200. PMID 14557255.
- ^ a b Schuster B, Kovaleva M, Sun Y, Regenhard P, Matthews V, Grötzinger J, Rose-John S, Kallen KJ (Mar 2003). "Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF". J. Biol. Chem. 278 (11): 9528–35. doi:10.1074/jbc.M210044200. PMID 12643274.
- ^ Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, Hirano T, Kishimoto T (Aug 1989). "Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130". Cell. 58 (3): 573–81. doi:10.1016/0092-8674(89)90438-8. PMID 2788034. S2CID 41245022.
- ^ Schooltink H, Stoyan T, Roeb E, Heinrich PC, Rose-John S (Dec 1992). "Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes". FEBS Lett. 314 (3): 280–4. doi:10.1016/0014-5793(92)81489-9. PMID 1281789. S2CID 39538295.
추가 읽기
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- Schooltink H, Stoyan T, Roeb E, Heinrich PC, Rose-John S (1992). "Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes". FEBS Lett. 314 (3): 280–4. doi:10.1016/0014-5793(92)81489-9. PMID 1281789. S2CID 39538295.
- Schooltink H, Stoyan T, Lenz D, Schmitz H, Hirano T, Kishimoto T, Heinrich PC, Rose-John S (1991). "Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells". Biochem. J. 277 ( Pt 3) (Pt 3): 659–64. doi:10.1042/bj2770659. PMC 1151293. PMID 1872801.
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- Sugita T, Totsuka T, Saito M, Yamasaki K, Taga T, Hirano T, Kishimoto T (1990). "Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis". J. Exp. Med. 171 (6): 2001–9. doi:10.1084/jem.171.6.2001. PMC 2187962. PMID 2112585.
- Snyers L, De Wit L, Content J (1990). "Glucocorticoid up-regulation of high-affinity interleukin 6 receptors on human epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 87 (7): 2838–42. Bibcode:1990PNAS...87.2838S. doi:10.1073/pnas.87.7.2838. PMC 53786. PMID 2157217.
- Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T (1990). "Molecular cloning and expression of an IL-6 signal transducer, gp130". Cell. 63 (6): 1149–57. doi:10.1016/0092-8674(90)90411-7. PMID 2261637. S2CID 30852638.
- Novick D, Engelmann H, Wallach D, Rubinstein M (1989). "Soluble cytokine receptors are present in normal human urine". J. Exp. Med. 170 (4): 1409–14. doi:10.1084/jem.170.4.1409. PMC 2189483. PMID 2529343.
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- Yamasaki K, Taga T, Hirata Y, Yawata H, Kawanishi Y, Seed B, Taniguchi T, Hirano T, Kishimoto T (1988). "Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor". Science. 241 (4867): 825–8. Bibcode:1988Sci...241..825Y. doi:10.1126/science.3136546. PMID 3136546.
- Horiuchi S, Koyanagi Y, Zhou Y, Miyamoto H, Tanaka Y, Waki M, Matsumoto A, Yamamoto M, Yamamoto N (1994). "Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism". Eur. J. Immunol. 24 (8): 1945–8. doi:10.1002/eji.1830240837. PMID 8056053. S2CID 33258406.
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- Yawata H, Yasukawa K, Natsuka S, Murakami M, Yamasaki K, Hibi M, Taga T, Kishimoto T (1993). "Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130". EMBO J. 12 (4): 1705–12. doi:10.1002/j.1460-2075.1993.tb05815.x. PMC 413384. PMID 8467812.
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외부 링크
- IL6R+단백질,+인간(MeSH) 미국 국립 의학 도서관의 의료 과목 제목(ILSH)
이 기사는 공공영역에 있는 미국 국립 의학 도서관의 텍스트를 통합하고 있다.
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