KiSS1 유래 펩타이드 수용체

키스1R1R
식별자
별칭	KISS1R, AXOR12, CPPB1, GPR54, HH8, HOT7T175, KISS-1R, KiSS1 유래 펩타이드 수용체, KISS1 수용체
외부 ID	OMIM: 604161 MGI: 2148793 호몰로진: 11411 진카드: KISS1R
유전자 위치(인간)
쳇.	19번 염색체(인간)
끝	921,005 bp
유전자 위치(마우스)
쳇.	10번 염색체(쥐)
끝	79,922,273 bp
RNA 표현 패턴
	표현된 상단
	물질적 해부학적 실체; ; 시상하부; ; 핵이 응축; ; 깡충깡충 뛰다; ; 핏덩어리; ; 프로센스팔론; ; 비뇨기 방광; ; 상전정핵; ; 머리를 쓰다;
	추가 참조 표현식 데이터
	n/a
유전자 온톨로지
분자함수	G 단백질 결합 펩타이드 수용체 활성; G 단백질 결합 수용체 활성; 신경펩타이드 수용체 활성; 신호 변환기 활동; GO:0001948 단백질 결합;
셀룰러 컴포넌트	막의 적분 성분; 세포내 막으로 둘러싸인 오르가넬; 막으로 막다; 플라즈마 막; 플라스마 막의 적분 성분; 세포표면; 실륨;
생물학적 과정	인지파아제 C 활성화 G 단백질 결합 수용체 신호 경로; 신호 전달; 신경펩타이드 신호 경로; G 단백질 결합 수용체 신호 경로;
	출처:아미고 / 퀵고
직교체
	84634
	114229
	ENSG00000116014
	ENSMUSG00000035773
	Q969F8
	Q91V45
	NM_032551
	NM_053244; NM_001359010
	NP_115940
	NP_444474; NP_001345939
	위키다타
인간 보기/편집	마우스 보기/편집

KiSS1 유래 펩타이드 수용체(GPR54 또는 Kiss펩틴 수용체라고도 한다)는 G 단백질 결합 수용체로^[5] 펩타이드 호르몬 키스펩틴(메타스틴)을 결합한다.^[6]^[7]^[8]키스펩틴은 전이 억제제 유전자 KISS1에 의해 암호화되는데, 이 유전자는 다양한 내분비 조직과 생식 조직으로 표현된다.^[9]키스펩틴 수용체의 활성화는 세포 내부의 인산염 C와 이노시톨 트리스인산염 두 번째 메신저 폭포와 연결된다.^[10]null

함수

키스펩틴은 내분비 기능 조절과 사춘기의 시작에 관여하는데, 키스펩틴 수용체가 고나도트로핀 방출 호르몬(GnRH)의 방출을 촉발시키고,^[11]^[12] 키스펩틴 자체의 방출을 옥스트라디올에 의해 억제되지만 GnRH에 의해 강화된다.^[13]나이와 함께 키스펩틴 수치의 감소는 역으로 호르몬의 루테인화와 같은 다른 내분비 호르몬의 수치의 감소의 원인 중 하나일 수 있다.^[14]null

리간즈

이 수용체에 대한 비펩타이드 리간드는 아직 발견되지 않았지만 2009년 현재 선택적 작용제 및 길항제 펩타이드 모두 알려져 있다.null

고민자

키스펩틴 (키스펩틴-54, 메타스틴)
키스펩틴-10(112-121 C-단자 파편)^[15]
KISS1-305
MVT-602(RVT-602, TAC-448)
TAK-683

반목자

아미노 대체물로^[16] 수정된 키스펩틴-10 아날로그
키스펩틴-234

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000116014 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000035773 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee DK, Nguyen T, O'Neill GP, Cheng R, Liu Y, Howard AD, Coulombe N, Tan CP, Tang-Nguyen AT, George SR, O'Dowd BF (Mar 1999). "Discovery of a receptor related to the galanin receptors". FEBS Letters. 446 (1): 103–7. doi:10.1016/S0014-5793(99)00009-5. PMID 10100623. S2CID 38910830.
^ Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M (May 2001). "Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor". Nature. 411 (6837): 613–7. Bibcode:2001Natur.411..613O. doi:10.1038/35079135. PMID 11385580. S2CID 205017670.
^ Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC (Aug 2001). "AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1". The Journal of Biological Chemistry. 276 (31): 28969–75. doi:10.1074/jbc.M102743200. PMID 11387329.
^ Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brézillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M (Sep 2001). "The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54". The Journal of Biological Chemistry. 276 (37): 34631–6. doi:10.1074/jbc.M104847200. PMID 11457843.
^ Richard N, Corvaisier S, Camacho E, Kottler ML (Jan 2009). "KiSS-1 and GPR54 at the pituitary level: overview and recent insights". Peptides. 30 (1): 123–9. doi:10.1016/j.peptides.2008.09.015. PMID 18948153. S2CID 22875820.
^ Liu X, Lee K, Herbison AE (Sep 2008). "Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels". Endocrinology. 149 (9): 4605–14. doi:10.1210/en.2008-0321. PMC 6116891. PMID 18483150.
^ Shahab M, Mastronardi C, Seminara SB, Crowley WF, Ojeda SR, Plant TM (Feb 2005). "Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates". Proceedings of the National Academy of Sciences of the United States of America. 102 (6): 2129–34. Bibcode:2005PNAS..102.2129S. doi:10.1073/pnas.0409822102. PMC 548549. PMID 15684075.
^ Plant TM, Ramaswamy S, Dipietro MJ (Feb 2006). "Repetitive activation of hypothalamic G protein-coupled receptor 54 with intravenous pulses of kisspeptin in the juvenile monkey (Macaca mulatta) elicits a sustained train of gonadotropin-releasing hormone discharges". Endocrinology. 147 (2): 1007–13. doi:10.1210/en.2005-1261. PMID 16282350.
^ Richard N, Galmiche G, Corvaisier S, Caraty A, Kottler ML (Mar 2008). "KiSS-1 and GPR54 genes are co-expressed in rat gonadotrophs and differentially regulated in vivo by oestradiol and gonadotrophin-releasing hormone". Journal of Neuroendocrinology. 20 (3): 381–93. doi:10.1111/j.1365-2826.2008.01653.x. PMID 18208554. S2CID 205345039.
^ Neal-Perry G, Lebesgue D, Lederman M, Shu J, Zeevalk GD, Etgen AM (Aug 2009). "The excitatory peptide kisspeptin restores the luteinizing hormone surge and modulates amino acid neurotransmission in the medial preoptic area of middle-aged rats". Endocrinology. 150 (8): 3699–708. doi:10.1210/en.2008-1667. PMC 2717872. PMID 19423763.
^ Mikkelsen JD, Bentsen AH, Ansel L, Simonneaux V, Juul A (Jan 2009). "Comparison of the effects of peripherally administered kisspeptins". Regulatory Peptides. 152 (1–3): 95–100. doi:10.1016/j.regpep.2008.10.001. PMID 18940206. S2CID 6587724.
^ Roseweir AK, Kauffman AS, Smith JT, Guerriero KA, Morgan K, Pielecka-Fortuna J, Pineda R, Gottsch ML, Tena-Sempere M, Moenter SM, Terasawa E, Clarke IJ, Steiner RA, Millar RP (Mar 2009). "Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation". The Journal of Neuroscience. 29 (12): 3920–9. doi:10.1523/JNEUROSCI.5740-08.2009. PMC 3035813. PMID 19321788.

추가 읽기

Colledge WH (Nov 2004). "GPR54 and puberty". Trends in Endocrinology and Metabolism. 15 (9): 448–53. doi:10.1016/j.tem.2004.09.008. PMID 15519892. S2CID 44517221.
Kaiser UB, Kuohung W (Apr 2005). "KiSS-1 and GPR54 as new players in gonadotropin regulation and puberty". Endocrine. 26 (3): 277–84. doi:10.1385/ENDO:26:3:277. PMID 16034182. S2CID 22795399.
Seminara SB (2006). "Metastin and its G protein-coupled receptor, GPR54: critical pathway modulating GnRH secretion". Frontiers in Neuroendocrinology. 26 (3–4): 131–8. doi:10.1016/j.yfrne.2005.10.001. PMID 16309735. S2CID 40864875.
Tena-Sempere M (2006). "GPR54 and kisspeptin in reproduction". Human Reproduction Update. 12 (5): 631–9. doi:10.1093/humupd/dml023. PMID 16731583.
Cerrato F, Seminara SB (Mar 2007). "Human genetics of GPR54". Reviews in Endocrine & Metabolic Disorders. 8 (1): 47–55. doi:10.1007/s11154-007-9027-3. PMID 17334928. S2CID 13041509.
Lee DK, Nguyen T, O'Neill GP, Cheng R, Liu Y, Howard AD, Coulombe N, Tan CP, Tang-Nguyen AT, George SR, O'Dowd BF (Mar 1999). "Discovery of a receptor related to the galanin receptors". FEBS Letters. 446 (1): 103–7. doi:10.1016/S0014-5793(99)00009-5. PMID 10100623. S2CID 38910830.
Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M (May 2001). "Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor". Nature. 411 (6837): 613–7. Bibcode:2001Natur.411..613O. doi:10.1038/35079135. PMID 11385580. S2CID 205017670.
Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC (Aug 2001). "AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1". The Journal of Biological Chemistry. 276 (31): 28969–75. doi:10.1074/jbc.M102743200. PMID 11387329.
Clements MK, McDonald TP, Wang R, Xie G, O'Dowd BF, George SR, Austin CP, Liu Q (Jun 2001). "FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54". Biochemical and Biophysical Research Communications. 284 (5): 1189–93. doi:10.1006/bbrc.2001.5098. PMID 11414709.
Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brézillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M (Sep 2001). "The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54". The Journal of Biological Chemistry. 276 (37): 34631–6. doi:10.1074/jbc.M104847200. PMID 11457843.
Hori A, Honda S, Asada M, Ohtaki T, Oda K, Watanabe T, Shintani Y, Yamada T, Suenaga M, Kitada C, Onda H, Kurokawa T, Nishimura O, Fujino M (Sep 2001). "Metastin suppresses the motility and growth of CHO cells transfected with its receptor". Biochemical and Biophysical Research Communications. 286 (5): 958–63. doi:10.1006/bbrc.2001.5470. PMID 11527393.
Ringel MD, Hardy E, Bernet VJ, Burch HB, Schuppert F, Burman KD, Saji M (May 2002). "Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells". The Journal of Clinical Endocrinology and Metabolism. 87 (5): 2399. doi:10.1210/jc.87.5.2399. PMID 11994395.
Janneau JL, Maldonado-Estrada J, Tachdjian G, Miran I, Motté N, Saulnier P, Sabourin JC, Coté JF, Simon B, Frydman R, Chaouat G, Bellet D (Nov 2002). "Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells". The Journal of Clinical Endocrinology and Metabolism. 87 (11): 5336–9. doi:10.1210/jc.2002-021093. PMID 12414911.
Bo-Abbas Y, Acierno JS, Shagoury JK, Crowley WF, Seminara SB (Jun 2003). "Autosomal recessive idiopathic hypogonadotropic hypogonadism: genetic analysis excludes mutations in the gonadotropin-releasing hormone (GnRH) and GnRH receptor genes". The Journal of Clinical Endocrinology and Metabolism. 88 (6): 2730–7. doi:10.1210/jc.2002-021948. PMID 12788881.
Ikeguchi M, Hirooka Y, Kaibara N (Sep 2003). "Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma". Journal of Cancer Research and Clinical Oncology. 129 (9): 531–5. doi:10.1007/s00432-003-0469-z. PMID 12898236. S2CID 20323621.
de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E (Sep 2003). "Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54". Proceedings of the National Academy of Sciences of the United States of America. 100 (19): 10972–6. Bibcode:2003PNAS..10010972D. doi:10.1073/pnas.1834399100. PMC 196911. PMID 12944565.
Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno JS, Shagoury JK, Bo-Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O'Rahilly S, Carlton MB, Crowley WF, Aparicio SA, Colledge WH (Oct 2003). "The GPR54 gene as a regulator of puberty". The New England Journal of Medicine. 349 (17): 1614–27. doi:10.1056/NEJMoa035322. PMID 14573733.
Ikeguchi M, Yamaguchi K, Kaibara N (Feb 2004). "Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma". Clinical Cancer Research. 10 (4): 1379–83. doi:10.1158/1078-0432.CCR-1519-02. PMID 14977840.
Bilban M, Ghaffari-Tabrizi N, Hintermann E, Bauer S, Molzer S, Zoratti C, Malli R, Sharabi A, Hiden U, Graier W, Knöfler M, Andreae F, Wagner O, Quaranta V, Desoye G (Mar 2004). "Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts". Journal of Cell Science. 117 (Pt 8): 1319–28. doi:10.1242/jcs.00971. PMID 15020672.

외부 링크

"KiSS1-Derived Peptide Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
KISS1R+단백질,+인간, 미국 국립 의학 도서관의 의학 과목 제목(MesH)

이 기사는 공공영역에 있는 미국 국립 의학 도서관의 텍스트를 통합하고 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000116014 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000035773 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10100623-5] Lee DK, Nguyen T, O'Neill GP, Cheng R, Liu Y, Howard AD, Coulombe N, Tan CP, Tang-Nguyen AT, George SR, O'Dowd BF (Mar 1999). "Discovery of a receptor related to the galanin receptors". FEBS Letters. 446 (1): 103–7. doi:10.1016/S0014-5793(99)00009-5. PMID 10100623. S2CID 38910830.

[pmid11385580-6] Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M (May 2001). "Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor". Nature. 411 (6837): 613–7. Bibcode:2001Natur.411..613O. doi:10.1038/35079135. PMID 11385580. S2CID 205017670.

[pmid11387329-7] Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC (Aug 2001). "AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1". The Journal of Biological Chemistry. 276 (31): 28969–75. doi:10.1074/jbc.M102743200. PMID 11387329.

[pmid11457843-8] Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brézillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M (Sep 2001). "The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54". The Journal of Biological Chemistry. 276 (37): 34631–6. doi:10.1074/jbc.M104847200. PMID 11457843.

[pmid18948153-9] Richard N, Corvaisier S, Camacho E, Kottler ML (Jan 2009). "KiSS-1 and GPR54 at the pituitary level: overview and recent insights". Peptides. 30 (1): 123–9. doi:10.1016/j.peptides.2008.09.015. PMID 18948153. S2CID 22875820.

[pmid18483150-10] Liu X, Lee K, Herbison AE (Sep 2008). "Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels". Endocrinology. 149 (9): 4605–14. doi:10.1210/en.2008-0321. PMC 6116891. PMID 18483150.

[pmid15684075-11] Shahab M, Mastronardi C, Seminara SB, Crowley WF, Ojeda SR, Plant TM (Feb 2005). "Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates". Proceedings of the National Academy of Sciences of the United States of America. 102 (6): 2129–34. Bibcode:2005PNAS..102.2129S. doi:10.1073/pnas.0409822102. PMC 548549. PMID 15684075.

[pmid16282350-12] Plant TM, Ramaswamy S, Dipietro MJ (Feb 2006). "Repetitive activation of hypothalamic G protein-coupled receptor 54 with intravenous pulses of kisspeptin in the juvenile monkey (Macaca mulatta) elicits a sustained train of gonadotropin-releasing hormone discharges". Endocrinology. 147 (2): 1007–13. doi:10.1210/en.2005-1261. PMID 16282350.

[pmid18208554-13] Richard N, Galmiche G, Corvaisier S, Caraty A, Kottler ML (Mar 2008). "KiSS-1 and GPR54 genes are co-expressed in rat gonadotrophs and differentially regulated in vivo by oestradiol and gonadotrophin-releasing hormone". Journal of Neuroendocrinology. 20 (3): 381–93. doi:10.1111/j.1365-2826.2008.01653.x. PMID 18208554. S2CID 205345039.

[pmid19423763-14] Neal-Perry G, Lebesgue D, Lederman M, Shu J, Zeevalk GD, Etgen AM (Aug 2009). "The excitatory peptide kisspeptin restores the luteinizing hormone surge and modulates amino acid neurotransmission in the medial preoptic area of middle-aged rats". Endocrinology. 150 (8): 3699–708. doi:10.1210/en.2008-1667. PMC 2717872. PMID 19423763.

[pmid18940206-15] Mikkelsen JD, Bentsen AH, Ansel L, Simonneaux V, Juul A (Jan 2009). "Comparison of the effects of peripherally administered kisspeptins". Regulatory Peptides. 152 (1–3): 95–100. doi:10.1016/j.regpep.2008.10.001. PMID 18940206. S2CID 6587724.

[pmid19321788-16] Roseweir AK, Kauffman AS, Smith JT, Guerriero KA, Morgan K, Pielecka-Fortuna J, Pineda R, Gottsch ML, Tena-Sempere M, Moenter SM, Terasawa E, Clarke IJ, Steiner RA, Millar RP (Mar 2009). "Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation". The Journal of Neuroscience. 29 (12): 3920–9. doi:10.1523/JNEUROSCI.5740-08.2009. PMC 3035813. PMID 19321788.

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KiSS1 유래 펩타이드 수용체

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