CEACAM1
CEACAM1
카르시노엠브릴론 항원 관련 세포 접착분자 1(담도 당단백질)(CEACAM1)은 CD66a(분화 66a)로도 알려져 있으며, 인간 당단백질이며, 카르시노엠브릴론 항원(CEA) 유전자 계열의 일원이다.[5]
함수
이 유전자는 면역글로불린 슈퍼패밀리에 속하는 카르시노엠브리오닉 항원(CEA) 유전자 계열의 한 구성원을 암호화한 것이다.CEA 계열의 두 부분군인 CEA 세포 접착 분자와 임신 특이 당단백질은 19번 염색체의 긴 팔에서 1.2Mb 군집 내에 위치한다.CEA 세포 접착 분자 부분군의 11개의 유사 유전자 또한 성단에서 발견된다.인코딩된 단백질은 원래 간 담도 당단백질이라고 간 담즙관에 설명되었다.이어 백혈구, 상피, 내피에서 검출된 세포-세포 접착 분자로 밝혀졌다.인코딩된 단백질은 하위 그룹의 다른 단백질에 대한 이질 결합뿐만 아니라 동질성을 통해 세포 유착을 매개한다.조직 3차원 구조의 분화와 배열의 역할, 혈관신생, 사멸, 종양 억제, 전이, 선천적 및 적응적 면역 반응의 변조 등 인코딩된 단백질이 복합적으로 작용했기 때문이다.서로 다른 ISO 양식을 인코딩하는 복수의 대본 변형이 보고되었지만, 단 두 가지에 대해서만 전체 길이 특성이 결정되었다.[5]
멜라노사이트 세포에서는 CEACAM1 유전자 발현이 MITF에 의해 조절될 수 있다.[6]
상호작용
CEACAM1은 PTPN11[7] 및 Annexin A2와 상호작용하는 것으로 나타났다.[8]
참고 항목
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG000079385 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000054385 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)".
- ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
- ^ Huber M, Izzi L, Grondin P, Houde C, Kunath T, Veillette A, Beauchemin N (January 1999). "The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells". The Journal of Biological Chemistry. 274 (1): 335–44. doi:10.1074/jbc.274.1.335. PMID 9867848.
- ^ Kirshner J, Schumann D, Shively JE (December 2003). "CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis". The Journal of Biological Chemistry. 278 (50): 50338–45. doi:10.1074/jbc.M309115200. PMID 14522961.
추가 읽기
- Gray-Owen SD, Blumberg RS (June 2006). "CEACAM1: contact-dependent control of immunity". Nature Reviews. Immunology. 6 (6): 433–46. doi:10.1038/nri1864. PMID 16724098. S2CID 34156579.
- Svenberg T, Hammarström S, Zeromski J (June 1979). "Immunofluorescence studies on the occurrence and localization of the CEA-related biliary glycoprotein I (BGP I) in normal human gastrointestinal tissues". Clinical and Experimental Immunology. 36 (3): 436–41. PMC 1537745. PMID 385181.
- Thompson J, Zimmermann W, Osthus-Bugat P, Schleussner C, Eades-Perner AM, Barnert S, Von Kleist S, Willcocks T, Craig I, Tynan K (April 1992). "Long-range chromosomal mapping of the carcinoembryonic antigen (CEA) gene family cluster". Genomics. 12 (4): 761–72. doi:10.1016/0888-7543(92)90307-E. PMID 1572649.
- Kuroki M, Arakawa F, Matsuo Y, Oikawa S, Nakazato H, Matsuoka Y (April 1991). "Three novel molecular forms of biliary glycoprotein deduced from cDNA clones from a human leukocyte library". Biochemical and Biophysical Research Communications. 176 (2): 578–85. doi:10.1016/S0006-291X(05)80223-2. PMID 2025273.
- Hinoda Y, Neumaier M, Hefta SA, Drzeniek Z, Wagener C, Shively L, Hefta LJ, Shively JE, Paxton RJ (September 1988). "Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen". Proceedings of the National Academy of Sciences of the United States of America. 85 (18): 6959–63. Bibcode:1988PNAS...85.6959H. doi:10.1073/pnas.85.18.6959. PMC 282098. PMID 2457922.
- Barnett TR, Kretschmer A, Austen DA, Goebel SJ, Hart JT, Elting JJ, Kamarck ME (February 1989). "Carcinoembryonic antigens: alternative splicing accounts for the multiple mRNAs that code for novel members of the carcinoembryonic antigen family". The Journal of Cell Biology. 108 (2): 267–76. doi:10.1083/jcb.108.2.267. PMC 2115422. PMID 2537311.
- Neumaier M, Paululat S, Chan A, Matthaes P, Wagener C (November 1993). "Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas". Proceedings of the National Academy of Sciences of the United States of America. 90 (22): 10744–8. Bibcode:1993PNAS...9010744N. doi:10.1073/pnas.90.22.10744. PMC 47854. PMID 7504281.
- Formisano P, Najjar SM, Gross CN, Philippe N, Oriente F, Kern-Buell CL, Accili D, Gorden P (October 1995). "Receptor-mediated internalization of insulin. Potential role of pp120/HA4, a substrate of the insulin receptor kinase". The Journal of Biological Chemistry. 270 (41): 24073–7. doi:10.1074/jbc.270.26.15844. PMID 7592607.
- Frängsmyr L, Baranov V, Prall F, Yeung MM, Wagener C, Hammarström S (July 1995). "Cell- and region-specific expression of biliary glycoprotein and its messenger RNA in normal human colonic mucosa". Cancer Research. 55 (14): 2963–7. PMID 7606710.
- Najjar SM, Philippe N, Suzuki Y, Ignacio GA, Formisano P, Accili D, Taylor SI (July 1995). "Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase". Biochemistry. 34 (29): 9341–9. doi:10.1021/bi00029a009. PMID 7626603.
- Nédellec P, Turbide C, Beauchemin N (July 1995). "Characterization and transcriptional activity of the mouse biliary glycoprotein 1 gene, a carcinoembryonic antigen-related gene". European Journal of Biochemistry. 231 (1): 104–14. doi:10.1111/j.1432-1033.1995.tb20676.x. PMID 7628460.
- Watt SM, Fawcett J, Murdoch SJ, Teixeira AM, Gschmeissner SE, Hajibagheri NM, Simmons DL (July 1994). "CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant". Blood. 84 (1): 200–10. doi:10.1182/blood.V84.1.200.200. PMID 8018919.
- Hauck W, Nédellec P, Turbide C, Stanners CP, Barnett TR, Beauchemin N (July 1994). "Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas". European Journal of Biochemistry. 223 (2): 529–41. doi:10.1111/j.1432-1033.1994.tb19022.x. PMID 8055923.
- Barnett TR, Drake L, Pickle W (February 1993). "Human biliary glycoprotein gene: characterization of a family of novel alternatively spliced RNAs and their expressed proteins". Molecular and Cellular Biology. 13 (2): 1273–82. doi:10.1128/mcb.13.2.1273. PMC 359012. PMID 8423792.
- Kuroki M, Yamanaka T, Matsuo Y, Oikawa S, Nakazato H, Matsuoka Y (August 1995). "Immunochemical analysis of carcinoembryonic antigen (CEA)-related antigens differentially localized in intracellular granules of human neutrophils". Immunological Investigations. 24 (5): 829–43. doi:10.3109/08820139509060710. PMID 8543346.
- Huber M, Izzi L, Grondin P, Houde C, Kunath T, Veillette A, Beauchemin N (January 1999). "The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells". The Journal of Biological Chemistry. 274 (1): 335–44. doi:10.1074/jbc.274.1.335. PMID 9867848.
- Feuk-Lagerstedt E, Jordan ET, Leffler H, Dahlgren C, Karlsson A (November 1999). "Identification of CD66a and CD66b as the major galectin-3 receptor candidates in human neutrophils". Journal of Immunology. 163 (10): 5592–8. PMID 10553088.
- Soni P, Lakkis M, Poy MN, Fernström MA, Najjar SM (June 2000). "The differential effects of pp120 (Ceacam 1) on the mitogenic action of insulin and insulin-like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptor". Molecular and Cellular Biology. 20 (11): 3896–905. doi:10.1128/MCB.20.11.3896-3905.2000. PMC 85733. PMID 10805733.
- Ergün S, Kilik N, Ziegeler G, Hansen A, Nollau P, Götze J, Wurmbach JH, Horst A, Weil J, Fernando M, Wagener C (February 2000). "CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor". Molecular Cell. 5 (2): 311–20. doi:10.1016/S1097-2765(00)80426-8. PMID 10882072.
- Wang L, Lin SH, Wu WG, Kemp BL, Walsh GL, Hong WK, Mao L (August 2000). "C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers". Clinical Cancer Research. 6 (8): 2988–93. PMID 10955775.
외부 링크
- CEACAM1+단백질,+인간, 미국 국립 의학 도서관의 의학 과목 제목(MesH)
- UCSC 게놈 브라우저의 인간 CEACAM1 유전체 위치 및 CEACAM1 유전자 세부 정보 페이지.
이 기사는 공공영역에 있는 미국 국립 의학 도서관의 텍스트를 통합하고 있다.
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