췌장폴리펩타이드수용체1

NPY4R
식별자
에일리어스	NPY4R, NPY4-R, PP1, PPYR1, Y4, 췌장폴리펩타이드수용체1, 신경펩타이드Y수용체Y4
외부 ID	OMIM : 601790 HomoloGene : 116086 GenCard : NPY4R
유전자 위치(인간)
크르.	10번 염색체(인간)
끝.	46,465,958 bp
RNA발현패턴
	상단 표시 위치:
	직장; ; 횡결장; ; 십이지장; ; 평활근 조직; ; 복부 피부; ; 부록; ; 배; ; 위체; ; 안저; ; 전립선;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	신경펩타이드Y수용체활성; G단백질결합수용체활성; 신호 변환기 활성; 췌장폴리펩티드수용체활성; 펩타이드 호르몬 결합;
셀룰러 컴포넌트	막의 적분 성분; 혈장막; 혈장막의 적분 성분; 막;
생물학적 과정	GO:0072468 신호 변환; 신경펩티드신호경로; 화학적 시냅스 전달; G단백질결합수용체신호경로;
	출처:아미고 / QuickGO
맞춤법
	5540
	없음
	ENSG00000204174
	없음
	P0DQD5; P50391
	없음
	NM_001278794; NM_005972
	없음
	NP_001265724; NP_001265723; NP_005963; NP_001265724
	없음
	위키데이터
인간 보기/편집

Neuro펩타이드 Y 수용체 타입 4로도 알려진 췌장 폴리펩타이드 수용체 1은 PPYR1 ^[3]^[4]유전자에 의해 인간에게 암호화되는 단백질이다.

선택적 배위자

어거니스트

췌장폴리펩타이드
신경펩타이드 Y(내생작용제, 비아형선택제)
펩타이드 YY
GR-231,118(혼합₁ NPY 길항제/NPY₄ 작용제, CAS#158859-98-4)

대항마

UR-AK49^[5]

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신경펩타이드Y수용체

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000204174 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (Dec 1997). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics. 46 (2): 287–90. doi:10.1006/geno.1997.5024. PMID 9417917.
^ "Entrez Gene: PPYR1 pancreatic polypeptide receptor 1".
^ Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A (2007). "Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence". Journal of Receptor and Signal Transduction Research. 27 (4): 217–33. doi:10.1080/10799890701505206. PMID 17885919. S2CID 26579625.

외부 링크

"Neuropeptide Y Receptors: Y₄". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

추가 정보

Keire DA, Bowers CW, Solomon TE, Reeve JR (Feb 2002). "Structure and receptor binding of PYY analogs". Peptides. 23 (2): 305–21. doi:10.1016/S0196-9781(01)00602-7. PMID 11825645. S2CID 7082920.
Balasubramaniam A (Apr 2002). "Clinical potentials of neuropeptide Y family of hormones". American Journal of Surgery. 183 (4): 430–4. doi:10.1016/S0002-9610(02)00803-6. PMID 11975932.
Parker E, Van Heek M, Stamford A (Apr 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology. 440 (2–3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.
Benaim G, Villalobo A (Aug 2002). "Phosphorylation of calmodulin. Functional implications". European Journal of Biochemistry. 269 (15): 3619–31. doi:10.1046/j.1432-1033.2002.03038.x. hdl:10261/79981. PMID 12153558.
Lundell I, Blomqvist AG, Berglund MM, Schober DA, Johnson D, Statnick MA, Gadski RA, Gehlert DR, Larhammar D (Dec 1995). "Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY". The Journal of Biological Chemistry. 270 (49): 29123–8. doi:10.1074/jbc.270.49.29123. PMID 7493937.
Bard JA, Walker MW, Branchek TA, Weinshank RL (Nov 1995). "Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY". The Journal of Biological Chemistry. 270 (45): 26762–5. doi:10.1074/jbc.270.45.26762. PMID 7592911.
Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W (May 1996). "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 4661–5. Bibcode:1996PNAS...93.4661Y. doi:10.1073/pnas.93.10.4661. PMC 39335. PMID 8643460.
Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615): 454–8. Bibcode:1997Natur.385..454K. doi:10.1038/385454a0. PMID 9009195. S2CID 608633.
Darby K, Eyre HJ, Lapsys N, Copeland NG, Gilbert DJ, Couzens M, Antonova O, Sutherland GR, Jenkins NA, Herzog H (Dec 1997). "Assignment of the Y4 receptor gene (PPYR1) to human chromosome 10q11.2 and mouse chromosome 14". Genomics. 46 (3): 513–5. doi:10.1006/geno.1997.5071. PMID 9441761.
Hsieh-Wilson LC, Allen PB, Watanabe T, Nairn AC, Greengard P (Apr 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. 38 (14): 4365–73. doi:10.1021/bi982900m. PMID 10194355.
Smith FD, Oxford GS, Milgram SL (Jul 1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein". The Journal of Biological Chemistry. 274 (28): 19894–900. doi:10.1074/jbc.274.28.19894. PMID 10391935.
Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR (May 2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts". Cell. 101 (4): 365–76. doi:10.1016/S0092-8674(00)80847-8. PMID 10830164. S2CID 6496567.
Connor JH, Weiser DC, Li S, Hallenbeck JM, Shenolikar S (Oct 2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Molecular and Cellular Biology. 21 (20): 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. PMC 99861. PMID 11564868.
Cavadas C, Silva AP, Mosimann F, Cotrim MD, Ribeiro CA, Brunner HR, Grouzmann E (Dec 2001). "NPY regulates catecholamine secretion from human adrenal chromaffin cells". The Journal of Clinical Endocrinology and Metabolism. 86 (12): 5956–63. doi:10.1210/jcem.86.12.8091. PMID 11739470.
Cox HM, Tough IR (Mar 2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". British Journal of Pharmacology. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMC 1573267. PMID 11906964.
Wu DY, Tkachuck DC, Roberson RS, Schubach WH (Aug 2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". The Journal of Biological Chemistry. 277 (31): 27706–15. doi:10.1074/jbc.M200955200. PMID 12016208.

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

이 막 통과 수용체 관련 기사는 스텁이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000204174 - 앙상블, 2017년 5월

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9417917-3] Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (Dec 1997). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics. 46 (2): 287–90. doi:10.1006/geno.1997.5024. PMID 9417917.

[entrez-4] "Entrez Gene: PPYR1 pancreatic polypeptide receptor 1".

[pmid17885919-5] Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A (2007). "Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence". Journal of Receptor and Signal Transduction Research. 27 (4): 217–33. doi:10.1080/10799890701505206. PMID 17885919. S2CID 26579625.

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