콜레시스토키닌A수용체
Cholecystokinin A receptor| CCKAR | |||||||||||||||||||||||||
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| 식별자 | |||||||||||||||||||||||||
| 별칭 | CCKAR, CCK-A, CCK1-R, CCK1R, CCKRA, 첼시스토킨 A 수용체 | ||||||||||||||||||||||||
| 외부 ID | OMIM: 118444 MGI: 99478 HomoloGene: 37337 GeneCard: CCKAR | ||||||||||||||||||||||||
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| 직교체 | |||||||||||||||||||||||||
| 종 | 인간 | 마우스 | |||||||||||||||||||||||
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| 앙상블 | |||||||||||||||||||||||||
| 유니프로트 | |||||||||||||||||||||||||
| RefSeq(mRNA) | |||||||||||||||||||||||||
| RefSeq(단백질) | |||||||||||||||||||||||||
| 위치(UCSC) | Cr 4: 26.48 – 26.49Mb | Cr 5: 53.7 – 53.71Mb | |||||||||||||||||||||||
| PubMed 검색 | [3] | [4] | |||||||||||||||||||||||
| 위키다타 | |||||||||||||||||||||||||
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| 콜레시스토키닌 A 수용체, N단자 영역 | |||||||||
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 nmr 분광법에 의한 수용체 쉘시스토키닌-8과 셀시스토키닌의 분자 복합체 | |||||||||
| 식별자 | |||||||||
| 기호 | CholecySA-Rec_N | ||||||||
| Pfam | PF09193 | ||||||||
| 인터프로 | IPR015276 | ||||||||
| SCOP2 | 1d6g / SCOPe / SUPFAM | ||||||||
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Cholecystokinin A 수용체는 CCKAR 또는 CCK라고도1 알려진 인간의 단백질로, 현재 CCK는1 IUPHAR이 권장하는 명칭이다.null
함수
이 유전자는 펩타이드 호르몬의 쉘시스토키닌(CCK) 계열의 황화 부재를 결합하는 G단백질 결합 수용체를 암호화한다.이 수용기는 췌장 효소 분비와 담낭과 위장의 원활한 근육수축의 주요 생리학적 매개체다.중추신경계와 말초신경계에서 이 수용체는 포만감과 베타엔돌핀과 도파민의 분비를 조절한다.[5]null
이 단백질의 세포외, N-단자, 영역은 몇 개의 헬리컬 턴과 이황화-크로스 링크 루프로 구성된 3차 구조를 채택한다.셀시스토킨 A 수용체와 해당 호르몬 리간드의 상호작용을 위해 필요하다.[6]null
선택적 리간즈
고민자
- 슐레시스토키닌
- 가스트린
- CCK-4
- SR-146,131
- A-71623 - 개조된 테트라펩타이드, 강력하고 선택적인 CCKA 작용제, IC50 3.7nM, CCK에B 대한 1200배 선택성, CAS# 130408-77-4
반목자
참고 항목
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000163394 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000029193 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: CCKAR cholecystokinin A receptor".
- ^ Pellegrini M, Mierke DF (Nov 1999). "Molecular complex of cholecystokinin-8 and N-terminus of the cholecystokinin A receptor by NMR spectroscopy". Biochemistry. 38 (45): 14775–83. doi:10.1021/bi991272l. PMID 10555959.
외부 링크
- "Cholecystokinin Receptors: CCK1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
추가 읽기
- Varga G, Bálint A, Burghardt B, D'Amato M (Apr 2004). "Involvement of endogenous CCK and CCK1 receptors in colonic motor function". British Journal of Pharmacology. 141 (8): 1275–84. doi:10.1038/sj.bjp.0705769. PMC 1574909. PMID 15100163.
- Wang J, Si YM, Liu ZL, Yu L (Jun 2003). "Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene polymorphisms in Parkinson's disease". Pharmacogenetics. 13 (6): 365–9. doi:10.1097/00008571-200306000-00008. PMID 12777967.
- Miller LJ, Holicky EL, Ulrich CD, Wieben ED (Oct 1995). "Abnormal processing of the human cholecystokinin receptor gene in association with gallstones and obesity". Gastroenterology. 109 (4): 1375–80. doi:10.1016/0016-5085(95)90601-0. PMID 7557108.
- Huppi K, Siwarski D, Pisegna JR, Wank S (Feb 1995). "Chromosomal localization of the gastric and brain receptors for cholecystokinin (CCKAR and CCKBR) in human and mouse". Genomics. 25 (3): 727–9. doi:10.1016/0888-7543(95)80018-H. PMC 6736545. PMID 7759110.
- de Weerth A, Pisegna JR, Huppi K, Wank SA (Jul 1993). "Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor". Biochemical and Biophysical Research Communications. 194 (2): 811–8. doi:10.1006/bbrc.1993.1894. PMID 8343165.
- Ulrich CD, Ferber I, Holicky E, Hadac E, Buell G, Miller LJ (May 1993). "Molecular cloning and functional expression of the human gallbladder cholecystokinin A receptor". Biochemical and Biophysical Research Communications. 193 (1): 204–11. doi:10.1006/bbrc.1993.1610. PMID 8503909.
- Kennedy K, Gigoux V, Escrieut C, Maigret B, Martinez J, Moroder L, Fréhel D, Gully D, Vaysse N, Fourmy D (Jan 1997). "Identification of two amino acids of the human cholecystokinin-A receptor that interact with the N-terminal moiety of cholecystokinin". The Journal of Biological Chemistry. 272 (5): 2920–6. doi:10.1074/jbc.272.5.2920. PMID 9006937.
- Inoue H, Iannotti CA, Welling CM, Veile R, Donis-Keller H, Permutt MA (Jun 1997). "Human cholecystokinin type A receptor gene: cytogenetic localization, physical mapping, and identification of two missense variants in patients with obesity and non-insulin-dependent diabetes mellitus (NIDDM)". Genomics. 42 (2): 331–5. doi:10.1006/geno.1997.4749. PMID 9192855.
- Gigoux V, Escrieut C, Silvente-Poirot S, Maigret B, Gouilleux L, Fehrentz JA, Gully D, Moroder L, Vaysse N, Fourmy D (Jun 1998). "Met-195 of the cholecystokinin-A receptor interacts with the sulfated tyrosine of cholecystokinin and is crucial for receptor transition to high affinity state". The Journal of Biological Chemistry. 273 (23): 14380–6. doi:10.1074/jbc.273.23.14380. PMID 9603948.
- Funakoshi A, Fukamizu Y, Miyasaka K (2000). "Mechanism of cholecystokinin-A- receptor antagonist on human pancreatic exocrine secretion. Localization of CCK-A receptor in the human duodenum". Digestion. 60 Suppl 1: 75–80. doi:10.1159/000051459. PMID 10026437. S2CID 41117645.
- Gigoux V, Escrieut C, Fehrentz JA, Poirot S, Maigret B, Moroder L, Gully D, Martinez J, Vaysse N, Fourmy D (Jul 1999). "Arginine 336 and asparagine 333 of the human cholecystokinin-A receptor binding site interact with the penultimate aspartic acid and the C-terminal amide of cholecystokinin". The Journal of Biological Chemistry. 274 (29): 20457–64. doi:10.1074/jbc.274.29.20457. PMID 10400673.
- Gigoux V, Maigret B, Escrieut C, Silvente-Poirot S, Bouisson M, Fehrentz JA, Moroder L, Gully D, Martinez J, Vaysse N, Fourmy AD (Nov 1999). "Arginine 197 of the cholecystokinin-A receptor binding site interacts with the sulfate of the peptide agonist cholecystokinin". Protein Science. 8 (11): 2347–54. doi:10.1110/ps.8.11.2347. PMC 2144185. PMID 10595537.
- Funakoshi A, Miyasaka K, Matsumoto H, Yamamori S, Takiguchi S, Kataoka K, Takata Y, Matsusue K, Kono A, Shimokata H (Jan 2000). "Gene structure of human cholecystokinin (CCK) type-A receptor: body fat content is related to CCK type-A receptor gene promoter polymorphism". FEBS Letters. 466 (2–3): 264–6. doi:10.1016/S0014-5793(00)01080-2. PMID 10682840. S2CID 11683500.
- Tachikawa H, Harada S, Kawanishi Y, Okubo T, Shiraishi H (Apr 2000). "Novel polymorphisms of the human cholecystokinin A receptor gene: an association analysis with schizophrenia". American Journal of Medical Genetics. 96 (2): 141–5. doi:10.1002/(SICI)1096-8628(20000403)96:2<141::AID-AJMG3>3.0.CO;2-R. PMID 10893485.
- Giragossian C, Mierke DF (Apr 2001). "Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin A receptor". Biochemistry. 40 (13): 3804–9. doi:10.1021/bi002659n. PMID 11300760.
- Schmitz F, Schrader H, Otte J, Schmitz H, Stüber E, Herzig K, Schmidt WE (Sep 2001). "Identification of CCK-B/gastrin receptor splice variants in human peripheral blood mononuclear cells". Regulatory Peptides. 101 (1–3): 25–33. doi:10.1016/S0167-0115(01)00281-6. PMID 11495676. S2CID 22693627.
- Tachikawa H, Harada S, Kawanishi Y, Okubo T, Suzuki T (Sep 2001). "Linked polymorphisms (-333G>T and -286A>G) in the promoter region of the CCK-A receptor gene may be associated with schizophrenia". Psychiatry Research. 103 (2–3): 147–55. doi:10.1016/S0165-1781(01)00276-1. PMID 11549403. S2CID 24442175.
- Schmitz F, Göke MN, Otte JM, Schrader H, Reimann B, Kruse ML, Siegel EG, Peters J, Herzig KH, Fölsch UR, Schmidt WE (Dec 2001). "Cellular expression of CCK-A and CCK-B/gastrin receptors in human gastric mucosa". Regulatory Peptides. 102 (2–3): 101–10. doi:10.1016/S0167-0115(01)00307-X. PMID 11730982. S2CID 42131386.
- Okubo T, Harada S, Higuchi S, Matsushita S (Aug 2002). "Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism". Alcoholism: Clinical and Experimental Research. 26 (8 Suppl): 2S–5S. doi:10.1111/j.1530-0277.2002.tb02693.x. PMID 12198366.
- Takata Y, Takeda S, Kawanami T, Takiguchi S, Yoshida Y, Miyasaka K, Funakoshi A (2003). "Promoter analysis of human cholecystokinin type-A receptor gene". Journal of Gastroenterology. 37 (10): 815–20. doi:10.1007/s005350200135. PMID 12424565. S2CID 35526543.
이 기사는 공공영역에 있는 미국 국립 의학 도서관의 텍스트를 통합하고 있다.
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