FCGR1A

FCGR1A
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	4W4O, 4X4M, 4ZNE
식별자
별칭	FCGR1A, CD64, CD64A, FCRI, IGFR1, IgG 수용체 Ia의 FC 파편
외부 ID	OMIM: 146760 MGI: 95498 HomoloGene: 475 GeneCard: FCGR1A
유전자 위치(인간)
쳇.	염색체 1 (인간)
끝	149,792,518 bp
유전자 위치(마우스)
쳇.	3번 염색체(쥐)
끝	96,1965 bp
RNA 표현 패턴
	표현된 상단
	흑인의 실체; ; 핏덩어리; ; 편도체; ; 고환; ; 보석을 깔다; ; 머리를 쓰다; ; 본래의 해마; ; 오른쪽 관상동맥;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	GO:0001948 단백질 결합; IgG 바인딩;
셀룰러 컴포넌트	막의 적분 성분; 쇄석성 내피막; 초기 내막막; 막으로 막다; 플라즈마 막;
생물학적 과정	면역 체계 과정; 포식증, 삼켜짐; MHC 등급 I, TAP 의존성을 통한 외생 펩타이드 항원의 항원 처리 및 표시; 면역 반응; 혈소판 감염에 관련된 fc-감마 수용체 신호 경로; 신호 전달; 면역 반응 조절; 인터페론 매개 신호 경로; 수용체 매개 내포증; 선천적인 면역 반응; 단백질 타이로신키나아제 활성의 양성 조절;
	출처:아미고 / 퀵고
직교체
	2209
	14129
	ENSG00000150337
	ENSMUSG00000015947
	P12314
	P26151
	NM_000566
	NM_010186
NP_000557; NP_001365733; NP_001365734; NP_001365735; NP_001365736;
	NP_001365737; NP_001365738; NP_001365739; NP_001365740
	NP_034316
	위키다타
인간 보기/편집	마우스 보기/편집

고친화성 면역글로불린 감마선 수용체 I는 인간에서 FCGR1A 유전자에 의해 암호화된 단백질이다.^[5]^[6]^[7]

상호작용

FcgRI는 IgG의 Fc 부분을 결합하고 세포간 ITAM 모티브를 통해 호스트 셀의 활성화를 유발한다.^[8]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000150337 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000015947 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Maresco DL, Chang E, Theil KS, Francke U, Anderson CL (September 1996). "The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21". Cytogenetics and Cell Genetics. 73 (3): 157–63. doi:10.1159/000134330. PMID 8697799.
^ Maresco DL, Blue LE, Culley LL, Kimberly RP, Anderson CL, Theil KS (November 1998). "Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1". Cytogenetics and Cell Genetics. 82 (1–2): 71–4. doi:10.1159/000015067. PMID 9763663. S2CID 20290009.
^ "Entrez Gene: FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)".
^ 덴드리트 세포와 대식세포에서 Fcγ 수용체의 기능 Martin Guiliams Pierre Bruhns Yvan Saeys Hamida Hammad와 Bart N. Lambrecht 2014년 2월 14일 Volume 14 Nature Reviews 면역학

추가 읽기

Monteiro RC, Van De Winkel JG (2003). "IgA Fc receptors". Annual Review of Immunology. 21: 177–204. doi:10.1146/annurev.immunol.21.120601.141011. PMID 12524384.
Ernst LK, van de Winkel JG, Chiu IM, Anderson CL (Aug 1992). "Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products". The Journal of Biological Chemistry. 267 (22): 15692–700. doi:10.1016/S0021-9258(19)49591-4. PMID 1379234.
Benech PD, Sastry K, Iyer RR, Eichbaum QG, Raveh DP, Ezekowitz RA (Oct 1992). "Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure". The Journal of Experimental Medicine. 176 (4): 1115–23. doi:10.1084/jem.176.4.1115. PMC 2119393. PMID 1402657.
Porges AJ, Redecha PB, Doebele R, Pan LC, Salmon JE, Kimberly RP (Nov 1992). "Novel Fc gamma receptor I family gene products in human mononuclear cells". The Journal of Clinical Investigation. 90 (5): 2102–9. doi:10.1172/JCI116094. PMC 443278. PMID 1430234.
van de Winkel JG, Ernst LK, Anderson CL, Chiu IM (Jul 1991). "Gene organization of the human high affinity receptor for IgG, Fc gamma RI (CD64). Characterization and evidence for a second gene". The Journal of Biological Chemistry. 266 (20): 13449–55. doi:10.1016/S0021-9258(18)98860-5. PMID 1830050.
Eizuru Y, Minamishima Y (1989). "Induction of Fc (IgG) receptor(s) by simian cytomegaloviruses in human embryonic lung fibroblasts". Intervirology. 29 (6): 339–45. doi:10.1159/000150065. PMID 2852656.
Allen JM, Seed B (Jan 1989). "Isolation and expression of functional high-affinity Fc receptor complementary DNAs". Science. 243 (4889): 378–81. Bibcode:1989Sci...243..378A. doi:10.1126/science.2911749. PMID 2911749.
Allen JM, Seed B (Dec 1988). "Nucleotide sequence of three cDNAs for the human high affinity Fc receptor (FcRI)". Nucleic Acids Research. 16 (24): 11824. doi:10.1093/nar/16.24.11824. PMC 339124. PMID 2974947.
Indik ZK, Hunter S, Huang MM, Pan XQ, Chien P, Kelly C, Levinson AI, Kimberly RP, Schreiber AD (Jul 1994). "The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI". Experimental Hematology. 22 (7): 599–606. PMID 7516890.
Valerius T, Repp R, de Wit TP, Berthold S, Platzer E, Kalden JR, Gramatzki M, van de Winkel JG (Aug 1993). "Involvement of the high-affinity receptor for IgG (Fc gamma RI; CD64) in enhanced tumor cell cytotoxicity of neutrophils during granulocyte colony-stimulating factor therapy". Blood. 82 (3): 931–9. doi:10.1182/blood.V82.3.931.931. PMID 7687898.
Wang AV, Scholl PR, Geha RS (Sep 1994). "Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn". The Journal of Experimental Medicine. 180 (3): 1165–70. doi:10.1084/jem.180.3.1165. PMC 2191633. PMID 8064233.
Takai S, Kasama M, Yamada K, Kai N, Hirayama N, Namiki H, Taniyama T (Jan 1994). "Human high-affinity Fc gamma RI (CD64) gene mapped to chromosome 1q21.2-q21.3 by fluorescence in situ hybridization". Human Genetics. 93 (1): 13–5. doi:10.1007/BF00218905. PMID 8270248. S2CID 24623391.
Morton HC, van den Herik-Oudijk IE, Vossebeld P, Snijders A, Verhoeven AJ, Capel PJ, van de Winkel JG (Dec 1995). "Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association". The Journal of Biological Chemistry. 270 (50): 29781–7. doi:10.1074/jbc.270.50.29781. PMID 8530370.
De SK, Venkateshan CN, Seth P, Gajdusek DC, Gibbs CJ (Mar 1998). "Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines". Blood. 91 (6): 2108–17. doi:10.1182/blood.V91.6.2108. PMID 9490697.
Kyono WT, de Jong R, Park RK, Liu Y, Heisterkamp N, Groffen J, Durden DL (Nov 1998). "Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI)". Journal of Immunology. 161 (10): 5555–63. PMID 9820532.
Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L (Nov 1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". European Journal of Immunology. 28 (11): 3423–34. doi:10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2. PMID 9842885.
Gorgani NN, Altin JG, Parish CR (Aug 1999). "Histidine-rich glycoprotein regulates the binding of monomeric IgG and immune complexes to monocytes". International Immunology. 11 (8): 1275–82. doi:10.1093/intimm/11.8.1275. PMID 10421785.
Tridandapani S, Lyden TW, Smith JL, Carter JE, Coggeshall KM, Anderson CL (Jul 2000). "The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells". The Journal of Biological Chemistry. 275 (27): 20480–7. doi:10.1074/jbc.M909462199. PMID 10781611.

외부 링크

UniProt: P12314(PDBe-KB에서 인간 고친화성 면역글로불린 감마선 수용체 I(FGR1A))에 대한 PDB에서 사용할 수 있는 모든 구조 정보의 개요.

인간 염색체 1번 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

이 면역학 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000150337 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000015947 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8697799-5] Maresco DL, Chang E, Theil KS, Francke U, Anderson CL (September 1996). "The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21". Cytogenetics and Cell Genetics. 73 (3): 157–63. doi:10.1159/000134330. PMID 8697799.

[pmid9763663-6] Maresco DL, Blue LE, Culley LL, Kimberly RP, Anderson CL, Theil KS (November 1998). "Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1". Cytogenetics and Cell Genetics. 82 (1–2): 71–4. doi:10.1159/000015067. PMID 9763663. S2CID 20290009.

[entrez-7] "Entrez Gene: FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)".

[8] 덴드리트 세포와 대식세포에서 Fcγ 수용체의 기능 Martin Guiliams Pierre Bruhns Yvan Saeys Hamida Hammad와 Bart N. Lambrecht 2014년 2월 14일 Volume 14 Nature Reviews 면역학

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

v t 단백질: 분화의 군집(인간 분화의 군집 목록 참조)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83년 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158(a) d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218(a) b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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FCGR1A

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