멜라노코르틴5수용체

MC5R
식별자
에일리어스	MC5R, MC2, 멜라노코르틴5수용체
외부 ID	OMIM: 600042 MGI: 99420 HomoloGene: 4321 GeneCard: MC5R
유전자 위치(인간)
크르.	18번 염색체(인간)
끝.	13,827,323 bp
유전자 위치(마우스)
크르.	18번 염색체(쥐)
끝.	68,475,517 bp
RNA발현패턴
	상단 표시 위치:
	전전두피질; ; 흉선; ; 대상회; ; 복부 피부; ; 림프절; ; 외분비선; ; 머리; ; 시상하부; ; 결합 조직; ; 지방 조직;
	상단 표시 위치:
	눈물샘; ; 입술; ; 상완 삼두근; ; 복부 피부; ; 발목; ; 장피질; ; 안외근; ; 측두근; ; 이복근; ; 등살;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	멜라노코르틴수용체활성; 단백질 결합; G단백질결합수용체활성; 신호 변환기 활성; 호르몬 결합;
셀룰러 컴포넌트	막의 적분 성분; 혈장막; 혈장막의 적분 성분; 막; 세포내 해부학적 구조;
생물학적 과정	고리형 뉴클레오티드 세컨드 메신저와 결합된 G단백질 결합 수용체 신호 경로; 신호 변환; G단백질결합수용체신호경로; 아데닐산시클라아제활성화G단백질결합수용체신호경로;
	출처:아미고 / QuickGO
맞춤법
	4161
	17203
	ENSG00000176136
	ENSMUSG00000007480
	P33032
	P41149
	NM_005913
	NM_013596
	NP_005904
	NP_038624
	위키데이터
인간 보기/편집	마우스 표시/편집

멜라노코르틴 5 수용체(MCR₅)는 사람에게서 MC5R 유전자에 ^[5]^[6]의해 암호화되는 단백질이다.그것은 인간 ^[6]게놈의 18번 염색체에 위치해 있다.트랜스제닉 생쥐에서₅ MCR이 교란되었을 때, 그것은 그들의 외분비샘 교란을 유발하여 ^[7]피지 생성을 감소시켰다.

생리학

MC5R 정상적인 피지 생산을 위해 필요합니다.[7][8][9]MC5R의 Stimulation 지방에 골격 muscle[10]과 lypolysis에서 지방산 산화를 촉진한다.[11]MC5R 적혈구 분화에 필수적이다.[12]MC5R 염증에 관여하고 있다.[13][14]MC5R 열 항상성을 유지하도록 돕습니다.[8][15]

MC5R은 뇌에 각기 다른 수준 신체 활동에 따라 표현된다.[16]

페로몬즈

MC5R 크게 쥐(수정된 피지선 페로몬 생성에 관련되어)의 포피의 글랜드로 표현되어 있다.수컷 쥐들에MC5R 결핍은 방어적 행동을 촉진하고 다른 수컷 쥐들pheremonal 신호를 통해MC5R-deficient 남성을 공격하기 위해 공격적인 행동을 감소시킨다.[17][18][19]

MRAP

세포 안에서 Melanocortin 2수용체의 악세사리는 단백질(MRAP)함정 MC5R 단백질이다.[20]

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Melanocortin 수용체

레퍼런스

^ ^a ^b ^c GRCh38:Ensembl 방출 89:ENSG00000176136-Ensembl, 5월 2017년.
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000007480 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chhajlani V, Muceniece R, Wikberg JE (September 1993). "Molecular cloning of a novel human melanocortin receptor". Biochemical and Biophysical Research Communications. 195 (2): 866–73. doi:10.1006/bbrc.1993.2125. PMID 8396929.
^ ^a ^b "Entrez Gene: MC5R melanocortin 5 receptor".
^ ^a ^b Thiboutot D, Sivarajah A, Gilliland K, Cong Z, Clawson G (October 2000). "The melanocortin 5 receptor is expressed in human sebaceous glands and rat preputial cells". The Journal of Investigative Dermatology. 115 (4): 614–9. doi:10.1046/j.1523-1747.2000.00094.x. PMID 10998132.
^ ^a ^b Chen W, Kelly MA, Opitz-Araya X, Thomas RE, Low MJ, Cone RD (December 1997). "Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides". Cell. 91 (6): 789–98. doi:10.1016/S0092-8674(00)80467-5. PMID 9413988. S2CID 6251691.
^ Zhang L, Li WH, Anthonavage M, Pappas A, Rossetti D, Cavender D, Seiberg M, Eisinger M (June 2011). "Melanocortin-5 receptor and sebogenesis". Eur J Pharmacol. 660 (1): 202–206. doi:10.1016/j.ejphar.2010.10.100. PMID 21215742.
^ An JJ, Rhee Y, Kim SH, Kim DM, Han DH, Hwang JH, Jin YJ, Cha BS, Baik JH, Lee WT, Lim SK (February 2007). "Peripheral effect of alpha-melanocyte-stimulating hormone on fatty acid oxidation in skeletal muscle". The Journal of Biological Chemistry. 282 (5): 2862–70. doi:10.1074/jbc.M603454200. PMID 17127674.
^ Møller CL, Raun K, Jacobsen ML, Pedersen TÅ, Holst B, Conde-Frieboes KW, Wulff BS (July 2011). "Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved" (PDF). Mol Cell Endocrinol. 341 (1–2): 9–17. doi:10.1016/j.mce.2011.03.010. PMID 21616121. S2CID 31837693.
^ Simamura E, Arikawa T, Ikeda T, Shimada H, Shoji H, Masuta H, Nakajima Y, Otani H, Yonekura H, Hatta T (April 2015). "Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5". PLOS ONE. 10 (4): e0123232. Bibcode:2015PLoSO..1023232S. doi:10.1371/journal.pone.0123232. PMC 4393082. PMID 25860801.
^ Lee DJ, Taylor AW (October 2013). "Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice". J. Immunol. 191 (8): 4103–4111. doi:10.4049/jimmunol.1300182. PMC 3796047. PMID 24043903.
^ Jun DJ, Na KY, Kim W, Kwak D, Kwon EJ, Yoon JH, Yea K, Lee H, Kim J, Suh PG, Ryu SH, Kim KT (April 2010). "Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3-L1 adipocytes". J Mol Endocrinol. 44 (4): 225–236. doi:10.1677/JME-09-0161. PMC 3058511. PMID 20089716.
^ Lute B, Jou W, Lateef DM, Goldgof M, Xiao C, Piñol RA, Kravitz AV, Miller NR, Huang YG, Girardet C, Butler AA, Gavrilova O, Reitman ML (August 2014). "Biphasic effect of melanocortin agonists on metabolic rate and body temperature". Cell Metab. 20 (2): 333–345. doi:10.1016/j.cmet.2014.05.021. PMC 4126889. PMID 24981835.
^ Shukla C, Britton SL, Koch LG, Novak CM (July 2012). "Region-specific differences in brain melanocortin receptors in rats of the lean phenotype". NeuroReport. 23 (10): 596–600. doi:10.1097/WNR.0b013e328354f5c1. PMC 3831884. PMID 22643233.
^ Morgan C, Thomas RE, Cone RD (January 2004). "Melanocortin-5 receptor deficiency promotes defensive behavior in male mice". Horm. Behav. 45 (1): 56–63. doi:10.1016/j.yhbeh.2003.08.004. PMID 14733892. S2CID 32531156.
^ Morgan C, Thomas RE, Ma W, Novotny MV, Cone RD (February 2004). "Melanocortin-5 receptor deficiency reduces a pheromonal signal for aggression in male mice". Chem Senses. 29 (2): 111–115. doi:10.1093/chemse/bjh011. PMID 14977807.
^ Morgan C, Cone RD (January 2006). "Melanocortin-5 receptor deficiency in mice blocks a novel pathway influencing pheromone-induced aggression". Behav. Genet. 36 (2): 291–300. doi:10.1007/s10519-005-9024-9. PMID 16408249. S2CID 9659300.
^ Sebag JA, Hinkle PM (August 2009). "Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking". J Biol Chem. 284 (34): 22641–22648. doi:10.1074/jbc.M109.022400. PMC 2755671. PMID 19535343.

추가 정보

Fathi Z, Iben LG, Parker EM (January 1995). "Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype". Neurochemical Research. 20 (1): 107–13. doi:10.1007/BF00995160. PMID 7739752. S2CID 20792213.
Chowdhary BP, Gustavsson I, Wikberg JE, Chhajlani V (1994). "Localization of the human melanocortin-5 receptor gene (MC5R) to chromosome band 18p11.2 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 68 (1–2): 79–81. doi:10.1159/000133895. PMID 7956366.
Griffon N, Mignon V, Facchinetti P, Diaz J, Schwartz JC, Sokoloff P (April 1994). "Molecular cloning and characterization of the rat fifth melanocortin receptor". Biochemical and Biophysical Research Communications. 200 (2): 1007–14. doi:10.1006/bbrc.1994.1550. PMID 8179577.
Gantz I, Shimoto Y, Konda Y, Miwa H, Dickinson CJ, Yamada T (May 1994). "Molecular cloning, expression, and characterization of a fifth melanocortin receptor" (PDF). Biochemical and Biophysical Research Communications. 200 (3): 1214–20. doi:10.1006/bbrc.1994.1580. hdl:2027.42/31580. PMID 8185570.
Chhajlani V (February 1996). "Distribution of cDNA for melanocortin receptor subtypes in human tissues". Biochemistry and Molecular Biology International. 38 (1): 73–80. PMID 8932521.
Yang YK, Ollmann MM, Wilson BD, Dickinson C, Yamada T, Barsh GS, Gantz I (March 1997). "Effects of recombinant agouti-signaling protein on melanocortin action". Molecular Endocrinology. 11 (3): 274–80. doi:10.1210/mend.11.3.9898. PMID 9058374.
Frändberg PA, Xu X, Chhajlani V (July 1997). "Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH". Biochemical and Biophysical Research Communications. 236 (2): 489–92. doi:10.1006/bbrc.1997.6994. PMID 9240466.
Yang YK, Thompson DA, Dickinson CJ, Wilken J, Barsh GS, Kent SB, Gantz I (January 1999). "Characterization of Agouti-related protein binding to melanocortin receptors". Molecular Endocrinology. 13 (1): 148–55. doi:10.1210/me.13.1.148. PMID 9892020.
Hatta N, Dixon C, Ray AJ, Phillips SR, Cunliffe WJ, Dale M, Todd C, Meggit S, Birch-MacHin MA, Rees JL (April 2001). "Expression, candidate gene, and population studies of the melanocortin 5 receptor". The Journal of Investigative Dermatology. 116 (4): 564–70. doi:10.1046/j.0022-202x.2001.01286.x. PMID 11286624.
Bednarek MA, MacNeil T, Kalyani RN, Tang R, Van der Ploeg LH, Weinberg DH (October 2001). "Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro". Journal of Medicinal Chemistry. 44 (22): 3665–72. doi:10.1021/jm010165y. PMID 11606131.
Lapinsh M, Veiksina S, Uhlén S, Petrovska R, Mutule I, Mutulis F, Yahorava S, Prusis P, Wikberg JE (January 2005). "Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes". Molecular Pharmacology. 67 (1): 50–9. doi:10.1124/mol.104.002857. PMID 15470082. S2CID 13536417.
Lohoff FW, Berrettini WH (December 2005). "Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder". Psychiatric Genetics. 15 (4): 255–8. doi:10.1097/00041444-200512000-00007. PMID 16314755. S2CID 21170090.
Grieco P, Cai M, Han G, Trivedi D, Campiglia P, Novellino E, Hruby VJ (June 2007). "Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5". Peptides. 28 (6): 1191–6. doi:10.1016/j.peptides.2007.02.012. PMC 1955225. PMID 17482720.

외부 링크

"Melanocortin Receptors: MC₅". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

[refGRCh38Ensembl-1] GRCh38:Ensembl 방출 89:ENSG00000176136-Ensembl, 5월 2017년.

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG00000007480 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8396929-5] Chhajlani V, Muceniece R, Wikberg JE (September 1993). "Molecular cloning of a novel human melanocortin receptor". Biochemical and Biophysical Research Communications. 195 (2): 866–73. doi:10.1006/bbrc.1993.2125. PMID 8396929.

[entrez-6] "Entrez Gene: MC5R melanocortin 5 receptor".

[Thiboutot_2000-7] Thiboutot D, Sivarajah A, Gilliland K, Cong Z, Clawson G (October 2000). "The melanocortin 5 receptor is expressed in human sebaceous glands and rat preputial cells". The Journal of Investigative Dermatology. 115 (4): 614–9. doi:10.1046/j.1523-1747.2000.00094.x. PMID 10998132.

[ReferenceA-8] Chen W, Kelly MA, Opitz-Araya X, Thomas RE, Low MJ, Cone RD (December 1997). "Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides". Cell. 91 (6): 789–98. doi:10.1016/S0092-8674(00)80467-5. PMID 9413988. S2CID 6251691.

[9] Zhang L, Li WH, Anthonavage M, Pappas A, Rossetti D, Cavender D, Seiberg M, Eisinger M (June 2011). "Melanocortin-5 receptor and sebogenesis". Eur J Pharmacol. 660 (1): 202–206. doi:10.1016/j.ejphar.2010.10.100. PMID 21215742.

[10] An JJ, Rhee Y, Kim SH, Kim DM, Han DH, Hwang JH, Jin YJ, Cha BS, Baik JH, Lee WT, Lim SK (February 2007). "Peripheral effect of alpha-melanocyte-stimulating hormone on fatty acid oxidation in skeletal muscle". The Journal of Biological Chemistry. 282 (5): 2862–70. doi:10.1074/jbc.M603454200. PMID 17127674.

[11] Møller CL, Raun K, Jacobsen ML, Pedersen TÅ, Holst B, Conde-Frieboes KW, Wulff BS (July 2011). "Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved" (PDF). Mol Cell Endocrinol. 341 (1–2): 9–17. doi:10.1016/j.mce.2011.03.010. PMID 21616121. S2CID 31837693.

[12] Simamura E, Arikawa T, Ikeda T, Shimada H, Shoji H, Masuta H, Nakajima Y, Otani H, Yonekura H, Hatta T (April 2015). "Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5". PLOS ONE. 10 (4): e0123232. Bibcode:2015PLoSO..1023232S. doi:10.1371/journal.pone.0123232. PMC 4393082. PMID 25860801.

[13] Lee DJ, Taylor AW (October 2013). "Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice". J. Immunol. 191 (8): 4103–4111. doi:10.4049/jimmunol.1300182. PMC 3796047. PMID 24043903.

[14] Jun DJ, Na KY, Kim W, Kwak D, Kwon EJ, Yoon JH, Yea K, Lee H, Kim J, Suh PG, Ryu SH, Kim KT (April 2010). "Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3-L1 adipocytes". J Mol Endocrinol. 44 (4): 225–236. doi:10.1677/JME-09-0161. PMC 3058511. PMID 20089716.

[15] Lute B, Jou W, Lateef DM, Goldgof M, Xiao C, Piñol RA, Kravitz AV, Miller NR, Huang YG, Girardet C, Butler AA, Gavrilova O, Reitman ML (August 2014). "Biphasic effect of melanocortin agonists on metabolic rate and body temperature". Cell Metab. 20 (2): 333–345. doi:10.1016/j.cmet.2014.05.021. PMC 4126889. PMID 24981835.

[16] Shukla C, Britton SL, Koch LG, Novak CM (July 2012). "Region-specific differences in brain melanocortin receptors in rats of the lean phenotype". NeuroReport. 23 (10): 596–600. doi:10.1097/WNR.0b013e328354f5c1. PMC 3831884. PMID 22643233.

[17] Morgan C, Thomas RE, Cone RD (January 2004). "Melanocortin-5 receptor deficiency promotes defensive behavior in male mice". Horm. Behav. 45 (1): 56–63. doi:10.1016/j.yhbeh.2003.08.004. PMID 14733892. S2CID 32531156.

[18] Morgan C, Thomas RE, Ma W, Novotny MV, Cone RD (February 2004). "Melanocortin-5 receptor deficiency reduces a pheromonal signal for aggression in male mice". Chem Senses. 29 (2): 111–115. doi:10.1093/chemse/bjh011. PMID 14977807.

[19] Morgan C, Cone RD (January 2006). "Melanocortin-5 receptor deficiency in mice blocks a novel pathway influencing pheromone-induced aggression". Behav. Genet. 36 (2): 291–300. doi:10.1007/s10519-005-9024-9. PMID 16408249. S2CID 9659300.

[20] Sebag JA, Hinkle PM (August 2009). "Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking". J Biol Chem. 284 (34): 22641–22648. doi:10.1074/jbc.M109.022400. PMC 2755671. PMID 19535343.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

v t Melanocortin 수용체 모듈레이터
MC₁	어거니스트: ACTH(코티코트로핀) 아파멜라노티드(멜라노탄 I) BMS-470539 브레멜라노티드 HS-014 HS-024 MSH(α, β, δ) 멜라노탄 2세 모디멜라노티드 PL-8177 SHU-8914 SHU-9005 SHU-9119 SNAP-7941 대항마: ASIP
MC₂	어거니스트: ACTH(코티코트로핀) 알작타이드 코닥타이드 지락타이드 노르유삭타이드(펜타코삭타이드) 세락타이드 테트라코액티드(테트라코액트린, 코신트로핀) 토삭타이드(옥타코삭트린) 트리코액티드 트리데카타이드
MC₃	어거니스트: ACTH(코티코트로핀) 아파멜라노티드(멜라노탄 I) 브레멜라노티드 MSH(α, β, δ) 멜라노탄 2세 모디멜라노티드 PG-931 대항마: AGRP ASIP HS-014 ML-00253764 PG-106 SHU-8914 SHU-9005 SHU-9119
MC₄	어거니스트: ACTH(코티코트로핀) 아파멜라노티드(멜라노탄 I) AZD2820 BIM-22493 브레멜라노티드 LY-2112688 MSH(α, β, δ) 멜라노탄 2세 MK-0493 모디멜라노티드 PF-00446687 PG-931 PL-6983 Ro 27-3225 세트멜라노티드 THIQ 대항마: AGRP ASIP HS-014 HS-024 HS-131 JKC-363 MCL-0020 MCL-0042 MCL-0129 ML-00253764 MPB-10 SHU-8914 SHU-9005 SHU-9119 알 수 없음: 세막스
MC₅	어거니스트: ACTH(코티코트로핀) 아파멜라노티드(멜라노탄 I) 브레멜라노티드 HS-014 HS-024 MSH(α, β, δ) 멜라노탄 2세 모디멜라노티드 SHU-8914 SHU-9005 SHU-9119 대항마: ASIP ML-00253764 알 수 없음: 세막스
정렬되어 있지 않다	어거니스트: 알작타이드 코닥타이드 데르시멜라곤 지락타이드 노르유삭타이드(펜타코삭타이드) 세락타이드 테트라코액티드(테트라코액트린, 코신트로핀) 토삭타이드(옥타코삭트린) 트리코액티드 트리데카타이드
다른이들	프로페이드:리포트로핀(β, γ) N-POMC(NPP, pro-to-MSH) 프로오피오멜라노코르틴(POMC)

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멜라노코르틴5수용체

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생리학

페로몬즈

MRAP

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레퍼런스

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멜라노코르틴5수용체

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