트롬보모둘린

THBD
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	1ADX, 1DQB, 1DX5, 1EGT, 1FGD, 1FGE, 1HLT, 1TMR, 1ZAQ, 2ADX, 3GIS
식별자
별칭	THBD, AHUS6, BDCA3, CD141, THPH12, THRM, TM, 트롬보모듈린, BDCA-3
외부 ID	OMIM: 188040 MGI: 98736 HomoloGene: 308 GeneCard: THBD
유전자 위치(인간)
쳇.	20염색체(인간)
끝	23,049,672 bp
유전자 위치(마우스)
쳇.	염색체 2 (쥐)
끝	148,250,190 bp
RNA 표현 패턴
	표현된 상단
	좌관상동맥; ; 시신막; ; 폐를 끼치다; ; 오른쪽 폐; ; 부신; ; 랑게르한스 섬;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	칼슘 이온 결합; GO:0001948 단백질 결합; 투과 브레인 신호 수용체 활성; 신호 수용체 활성;
셀룰러 컴포넌트	막의 적분 성분; 세포표면; 플라즈마 막; 플라스마 막의 적분 성분; 막으로 막다; 사측 플라즈마 막; 대극막; 세포외 공간;
생물학적 과정	지혈; 여성 임신; 혈소판 활성화에 대한 부정적 규제; 지용성당류에 대한 반응; cAMP에 대한 대응; 섬유소 분해에 대한 부정적 규제; 혈액 응고; X선에 대한 반응; 신호 전달; 혈액 응고에 대한 부정적인 규제; 백혈구 이동;
	출처:아미고 / 퀵고
직교체
	7056
	21824
	ENSG00000178726
	ENSMUSG 000074743
	P07204
	P15306
	NM_000361
	NM_009378
	NP_000352
	NP_033404
	위키다타
인간 보기/편집	마우스 보기/편집

트롬보모둘린(TM), CD141 또는 BDCA-3는 내피세포 표면에 발현된 일체형 막단백질로 트롬빈의 공동 인자 역할을 한다.트롬빈을 프로코아겔란트 효소에서 항응고제 효소로 전환시켜 혈액 응고를 감소시킨다.^[5]트롬보모둘린은 또한 인간 중피세포,^[6] 단세포, 그리고 수지상세포 서브셋에도 표현된다.

유전학과 구조

인간에서 혈보모둘린은 THBD 유전자에 의해 암호화된다.^[7]단백질은 분자 질량이 74kDa이며, 6개의 탠덤 반복 EGF 유사 도메인과 세린/트레오닌이 풍부한 스페이서, 트랜섬브레인 도메인으로 구성되어 있다.^[8]C형 렉틴 도메인(CTLD) 그룹 14 계열의 회원이다.^[9]

함수

트롬보모둘린은 트롬빈과 1:1 스토오치메트릭 콤플렉스를 형성하여 항응고제 경로에서 단백질 C의 활성화에 있어 공작용제로 기능한다.이것은 단백질 C의 활성화 속도를 수천배 높인다.트롬보모듈린 결합트롬빈은 트롬빈 활성섬유리노해소억제제(TAFI, 일명 카복시펩티다제 B2)를 활성형태로 분해해 섬유리노해소를 억제해 프로코아겔란트 효과를 동시에 낸다.^{[citation needed]}

트롬보모둘린은 내피세포 표면에 있는 당단백질로서, 결합 트롬빈 외에 인자 I에 의해 C3b 불활성화를 조절한다.혈보모둘린 유전자의 돌연변이는 비정형 용혈성-유전증후군(a HUS)과도 관련이 있는 것으로 보고되었다.^[10]

BDCA-3로^[11] 기술된 항원은 혈보모듈린과 동일한 것으로 밝혀졌다.^[12]따라서, 이 분자는 MDC2라고 불리는 매우 희귀한 (0.02%) 부분집합에서 발생한다는 것이 밝혀졌다.이 세포들에 대한 그것의 기능은 알려져 있지 않다.^{[citation needed]}

상호작용

트롬보모둘린은 트롬빈과 상호작용을 하는 것으로 밝혀졌다.^[13]^[14]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000178726 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000074743 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ 2012년 1월 19일에 접속된 IPR001491 트롬보모둘린.
^ Verhagen HJ, Heijnen-Snyder GJ, Pronk A, Vroom TM, van Vroonhoven TJ, Eikelboom BC, et al. (December 1996). "Thrombomodulin activity on mesothelial cells: perspectives for mesothelial cells as an alternative for endothelial cells for cell seeding on vascular grafts". British Journal of Haematology. 95 (3): 542–549. doi:10.1046/j.1365-2141.1996.d01-1935.x. PMID 8943899. S2CID 8417511.
^ Wen DZ, Dittman WA, Ye RD, Deaven LL, Majerus PW, Sadler JE (July 1987). "Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene". Biochemistry. 26 (14): 4350–4357. doi:10.1021/bi00388a025. PMID 2822087.
^ Sadler JE (July 1997). "Thrombomodulin structure and function". Thrombosis and Haemostasis. 78 (1): 392–395. doi:10.1055/s-0038-1657558. PMID 9198185.
^ Khan KA, McMurray JL, Mohammed F, Bicknell R (September 2019). "C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation". The FEBS Journal. 286 (17): 3299–3332. doi:10.1111/febs.14985. PMC 6852297. PMID 31287944.
^ Delvaeye M, Noris M, De Vriese A, Esmon CT, Esmon NL, Ferrell G, et al. (July 2009). "Thrombomodulin mutations in atypical hemolytic-uremic syndrome". The New England Journal of Medicine. 361 (4): 345–357. doi:10.1056/NEJMoa0810739. PMC 3530919. PMID 19625716.
^ Dzionek A, Fuchs A, Schmidt P, Cremer S, Zysk M, Miltenyi S, et al. (December 2000). "BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood". Journal of Immunology. 165 (11): 6037–6046. doi:10.4049/jimmunol.165.11.6037. PMID 11086035.
^ Dzionek A, Inagaki Y, Okawa K, Nagafune J, Röck J, Sohma Y, et al. (December 2002). "Plasmacytoid dendritic cells: from specific surface markers to specific cellular functions". Human Immunology. 63 (12): 1133–1148. doi:10.1016/S0198-8859(02)00752-8. PMID 12480257.
^ Bajzar L, Morser J, Nesheim M (July 1996). "TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex". The Journal of Biological Chemistry. 271 (28): 16603–16608. doi:10.1074/jbc.271.28.16603. PMID 8663147.
^ Jakubowski HV, Owen WG (July 1989). "Macromolecular specificity determinants on thrombin for fibrinogen and thrombomodulin". The Journal of Biological Chemistry. 264 (19): 11117–11121. doi:10.1016/S0021-9258(18)60437-5. PMID 2544585.

추가 읽기

Esmon CT (July 1995). "Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface". FASEB Journal. 9 (10): 946–955. doi:10.1096/fasebj.9.10.7615164. PMID 7615164. S2CID 19565674.
Ohlin AK, Norlund L, Marlar RA (July 1997). "Thrombomodulin gene variations and thromboembolic disease". Thrombosis and Haemostasis. 78 (1): 396–400. doi:10.1055/s-0038-1657559. PMID 9198186.
Van de Wouwer M, Collen D, Conway EM (August 2004). "Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation". Arteriosclerosis, Thrombosis, and Vascular Biology. 24 (8): 1374–1383. doi:10.1161/01.ATV.0000134298.25489.92. PMID 15178554.
Boffa MC, Jackman RW, Peyri N, Boffa JF, George B (1991). "Thrombomodulin in the central nervous system". Nouvelle Revue Française d'Hématologie. 33 (6): 423–429. PMID 1667949.
Jackman RW, Beeler DL, Fritze L, Soff G, Rosenberg RD (September 1987). "Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control". Proceedings of the National Academy of Sciences of the United States of America. 84 (18): 6425–6429. Bibcode:1987PNAS...84.6425J. doi:10.1073/pnas.84.18.6425. PMC 299089. PMID 2819876.
Suzuki K, Kusumoto H, Deyashiki Y, Nishioka J, Maruyama I, Zushi M, et al. (July 1987). "Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation". The EMBO Journal. 6 (7): 1891–1897. doi:10.1002/j.1460-2075.1987.tb02448.x. PMC 553573. PMID 2820710.
Wen DZ, Dittman WA, Ye RD, Deaven LL, Majerus PW, Sadler JE (July 1987). "Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene". Biochemistry. 26 (14): 4350–4357. doi:10.1021/bi00388a025. PMID 2822087.
Shirai T, Shiojiri S, Ito H, Yamamoto S, Kusumoto H, Deyashiki Y, et al. (February 1988). "Gene structure of human thrombomodulin, a cofactor for thrombin-catalyzed activation of protein C". Journal of Biochemistry. 103 (2): 281–285. CiteSeerX 10.1.1.1006.6759. doi:10.1093/oxfordjournals.jbchem.a122261. PMID 2836377.
Yonezawa S, Maruyama I, Tanaka S, Nakamura T, Sato E (August 1988). "Immunohistochemical localization of thrombomodulin in chorionic diseases of the uterus and choriocarcinoma of the stomach. A comparative study with the distribution of human chorionic gonadotropin". Cancer. 62 (3): 569–576. doi:10.1002/1097-0142(19880801)62:3<569::AID-CNCR2820620322>3.0.CO;2-T. PMID 2839283.
Ishii H, Majerus PW (December 1985). "Thrombomodulin is present in human plasma and urine". The Journal of Clinical Investigation. 76 (6): 2178–2181. doi:10.1172/JCI112225. PMC 424339. PMID 3001144.
Adler M, Seto MH, Nitecki DE, Lin JH, Light DR, Morser J (October 1995). "The structure of a 19-residue fragment from the C-loop of the fourth epidermal growth factor-like domain of thrombomodulin". The Journal of Biological Chemistry. 270 (40): 23366–23372. doi:10.1074/jbc.270.40.23366. PMID 7559494.
Ohlin AK, Marlar RA (January 1995). "The first mutation identified in the thrombomodulin gene in a 45-year-old man presenting with thromboembolic disease". Blood. 85 (2): 330–336. doi:10.1182/blood.V85.2.330.330. PMID 7811989.
Srinivasan J, Hu S, Hrabal R, Zhu Y, Komives EA, Ni F (November 1994). "Thrombin-bound structure of an EGF subdomain from human thrombomodulin determined by transferred nuclear Overhauser effects". Biochemistry. 33 (46): 13553–13560. doi:10.1021/bi00250a007. PMID 7947766.
Gerlitz B, Hassell T, Vlahos CJ, Parkinson JF, Bang NU, Grinnell BW (October 1993). "Identification of the predominant glycosaminoglycan-attachment site in soluble recombinant human thrombomodulin: potential regulation of functionality by glycosyltransferase competition for serine474". The Biochemical Journal. 295 (1): 131–140. doi:10.1042/bj2950131. PMC 1134829. PMID 8216207.
Yasuda K, Espinosa R, Davis EM, Le Beau MM, Bell GI (September 1993). "Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2". Genomics. 17 (3): 785–786. doi:10.1006/geno.1993.1410. PMID 8244401.
Yamamoto S, Mizoguchi T, Tamaki T, Ohkuchi M, Kimura S, Aoki N (April 1993). "Urinary thrombomodulin, its isolation and characterization". Journal of Biochemistry. 113 (4): 433–440. doi:10.1093/oxfordjournals.jbchem.a124063. PMID 8390446.
Meininger DP, Hunter MJ, Komives EA (September 1995). "Synthesis, activity, and preliminary structure of the fourth EGF-like domain of thrombomodulin". Protein Science. 4 (9): 1683–1695. doi:10.1002/pro.5560040904. PMC 2143218. PMID 8528067.
Maglott DR, Feldblyum TV, Durkin AS, Nierman WC (May 1996). "Radiation hybrid mapping of SNAP, PCSK2, and THBD (human chromosome 20p)". Mammalian Genome. 7 (5): 400–401. doi:10.1007/s003359900120. PMID 8661740. S2CID 34951074.

외부 링크

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000178726 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000074743 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] 2012년 1월 19일에 접속된 IPR001491 트롬보모둘린.

[6] Verhagen HJ, Heijnen-Snyder GJ, Pronk A, Vroom TM, van Vroonhoven TJ, Eikelboom BC, et al. (December 1996). "Thrombomodulin activity on mesothelial cells: perspectives for mesothelial cells as an alternative for endothelial cells for cell seeding on vascular grafts". British Journal of Haematology. 95 (3): 542–549. doi:10.1046/j.1365-2141.1996.d01-1935.x. PMID 8943899. S2CID 8417511.

[pmid2822087-7] Wen DZ, Dittman WA, Ye RD, Deaven LL, Majerus PW, Sadler JE (July 1987). "Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene". Biochemistry. 26 (14): 4350–4357. doi:10.1021/bi00388a025. PMID 2822087.

[8] Sadler JE (July 1997). "Thrombomodulin structure and function". Thrombosis and Haemostasis. 78 (1): 392–395. doi:10.1055/s-0038-1657558. PMID 9198185.

[9] Khan KA, McMurray JL, Mohammed F, Bicknell R (September 2019). "C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation". The FEBS Journal. 286 (17): 3299–3332. doi:10.1111/febs.14985. PMC 6852297. PMID 31287944.

[10] Delvaeye M, Noris M, De Vriese A, Esmon CT, Esmon NL, Ferrell G, et al. (July 2009). "Thrombomodulin mutations in atypical hemolytic-uremic syndrome". The New England Journal of Medicine. 361 (4): 345–357. doi:10.1056/NEJMoa0810739. PMC 3530919. PMID 19625716.

[pmid11086035-11] Dzionek A, Fuchs A, Schmidt P, Cremer S, Zysk M, Miltenyi S, et al. (December 2000). "BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood". Journal of Immunology. 165 (11): 6037–6046. doi:10.4049/jimmunol.165.11.6037. PMID 11086035.

[pmid12480257-12] Dzionek A, Inagaki Y, Okawa K, Nagafune J, Röck J, Sohma Y, et al. (December 2002). "Plasmacytoid dendritic cells: from specific surface markers to specific cellular functions". Human Immunology. 63 (12): 1133–1148. doi:10.1016/S0198-8859(02)00752-8. PMID 12480257.

[pmid8663147-13] Bajzar L, Morser J, Nesheim M (July 1996). "TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex". The Journal of Biological Chemistry. 271 (28): 16603–16608. doi:10.1074/jbc.271.28.16603. PMID 8663147.

[pmid2544585-14] Jakubowski HV, Owen WG (July 1989). "Macromolecular specificity determinants on thrombin for fibrinogen and thrombomodulin". The Journal of Biological Chemistry. 264 (19): 11117–11121. doi:10.1016/S0021-9258(18)60437-5. PMID 2544585.

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v t 단백질: 분화의 군집(인간 분화의 군집 목록 참조)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83년 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158(a) d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218(a) b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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트롬보모둘린

네임스페이스

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목차

유전학과 구조

함수

상호작용

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