KER2DL4
KIR2DL4
킬러 세포 면역글로불린 유사 수용체 2DL4는 인간 내 KIR2DL4 유전자에 의해 암호화된 단백질이다.[3][4]
함수
킬러 세포 면역글로불린 유사 수용체(KIRs)는 자연 킬러 세포와 CD8+T 세포의 서브셋에 의해 발현되는 트랜섬브레인 당단백질이다.[5]KIR 유전자는 다형성 및 고동맥성으로 1Mb 백혈구 수용체 복합체(LRC) 내 염색체 19q13.4의 성단에서 발견된다.여러 "프레임워크" 유전자가 모든 하플라타입(KIR3DL3, KIR3DP1, KIR2DL4, KIR3DL2)에서 발견되지만 KIR 유전자 군집의 유전자 함량은 하플라타입에 따라 다르다.KIR 단백질은 세포외 면역글로불린 영역 수(2D 또는 3D)와 세포질 영역이 긴지 짧은지(S)로 분류된다.면역 티로신 기반 억제 모티브(ITIM)를 통해 리간드 결합 시 긴 세포질 영역 변환 억제 신호를 가진 KIR 단백질은 ITIM 모티브가 부족한 반면, 짧은 세포질 영역을 가진 KIR 단백질은 대신 TYRO 단백질 티로신 키나제 결합 단백질과 결합하여 변환 활성 신호를 만든다.몇몇 KIR 단백질의 리간드는 HLA 등급 I 분자의 하위 집합이므로, KIR 단백질은 면역 반응의 조절에 중요한 역할을 한다고 생각된다.이 유전자는 모든 happlotype에 존재하는 "framework" loci의 하나이다.대체 스플라이싱은 여러 대본을 변형하는 결과를 낳는다.[4]
지금까지 보고된 KER2DL4의 리간드는 비표준 HLA급 1유전자 HLA-G뿐이며, 이로 인해 낭성 NK세포 기능이 억제된다.[5]
참고 항목
참조
- ^ a b c ENSG00000278606, ENSG00000277540, ENSG00000273575, ENSG00000275732, ENSG00000275699, ENSG00000275317, ENSG00000284509, ENSG00000277750, ENSG00000284365, ENSG00000275848, ENSG00000275456, ENSG00000274955, ENSG00000277964, ENSG00000277362, ENSG00000276979, ENSG00000283961, ENSG00000277850, ENSG00000284460, ENSG00000278074, ENSG00000277076, ENSG00000274189, ENSG00000276044, ENSG00000276779, ENSG00000277355, ENSG00000283869, ENSG00000278201, ENSG00000278271, ENSG00000275237, ENSG00000189013, ENSG00000273498, ENSG00000274193, ENSG00000278430, ENSG00000274232, ENSG00000274609, ENSG00000284013, ENSG00000283986, ENSG00000284340, ENSG00000284562, ENSG00000284206, ENSG00000284457 GRCh38: Ensembl release 89: ENSG00000274945, ENSG00000278606, ENSG00000277540, ENSG00000273575, ENSG00000275732, ENSG00000275699, ENSG00000275317, ENSG00000284509, ENSG00000277750, ENSG00000284365, ENSG00000275848, ENSG00000275456, ENSG00000274955, ENSG00000277964, ENSG00000277362, ENSG00000276979, ENSG00000283961, ENSG00000277850, ENSG00000284460, ENSG00000278074, ENSG00000277076, ENSG00000274189, ENSG00000276044, ENSG00000276779, ENSG00000277355, ENSG00000283869, ENSG00000278201, ENSG00000278271, ENSG00000275237, ENSG00000189013, ENSG00000273498, ENSG00000274193, ENSG00000278430, ENSG00000274232, ENSG00000274609, ENSG00000284013, ENSG00000283986, ENSG00000284340, ENSG00000284562, ENSG00000284206, ENSG00000284457 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Selvakumar A, Steffens U, Dupont B (October 1996). "NK cell receptor gene of the KIR family with two IG domains but highest homology to KIR receptors with three IG domains". Tissue Antigens. 48 (4 Pt 1): 285–94. doi:10.1111/j.1399-0039.1996.tb02647.x. PMID 8946682.
- ^ a b "Entrez Gene: KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4".
- ^ a b Carosella ED, Favier B, Rouas-Freiss N, Moreau P, Lemaoult J (May 2008). "Beyond the increasing complexity of the immunomodulatory HLA-G molecule". Blood. 111 (10): 4862–70. doi:10.1182/blood-2007-12-127662. PMID 18334671.
추가 읽기
- Selvakumar A, Steffens U, Dupont B (1997). "Polymorphism and domain variability of human killer cell inhibitory receptors". Immunol. Rev. 155: 183–96. doi:10.1111/j.1600-065X.1997.tb00951.x. PMID 9059894. S2CID 7040904.
- Selvakumar A, Steffens U, Palanisamy N, Chaganti RS, Dupont B (1997). "Genomic organization and allelic polymorphism of the human killer cell inhibitory receptor gene KIR103". Tissue Antigens. 49 (6): 564–73. doi:10.1111/j.1399-0039.1997.tb02803.x. PMID 9234477.
- Valiante NM, Uhrberg M, Shilling HG, Lienert-Weidenbach K, Arnett KL, D'Andrea A, Phillips JH, Lanier LL, Parham P (1997). "Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors". Immunity. 7 (6): 739–51. doi:10.1016/S1074-7613(00)80393-3. PMID 9430220.
- Uhrberg M, Valiante NM, Shum BP, Shilling HG, Lienert-Weidenbach K, Corliss B, Tyan D, Lanier LL, Parham P (1997). "Human diversity in killer cell inhibitory receptor genes". Immunity. 7 (6): 753–63. doi:10.1016/S1074-7613(00)80394-5. PMID 9430221.
- Rajagopalan S, Long EO (1999). "A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells". J. Exp. Med. 189 (7): 1093–100. doi:10.1084/jem.189.7.1093. PMC 2193010. PMID 10190900.
- Rajalingam R, Gardiner CM, Canavez F, Vilches C, Parham P (2001). "Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors". Tissue Antigens. 57 (1): 22–31. doi:10.1034/j.1399-0039.2001.057001022.x. PMID 11169255.
- Rajagopalan S, Fu J, Long EO (2001). "Cutting edge: induction of IFN-gamma production but not cytotoxicity by the killer cell Ig-like receptor KIR2DL4 (CD158d) in resting NK cells". J. Immunol. 167 (4): 1877–81. doi:10.4049/jimmunol.167.4.1877. PMID 11489965.
- Witt CS, Whiteway JM, Warren HS, Barden A, Rogers M, Martin A, Beilin L, Christiansen FT (2002). "Alleles of the KIR2DL4 receptor and their lack of association with pre-eclampsia". Eur. J. Immunol. 32 (1): 18–29. doi:10.1002/1521-4141(200201)32:1<18::AID-IMMU18>3.0.CO;2-7. PMID 11754000.
- Yusa S, Catina TL, Campbell KS (2002). "SHP-1- and phosphotyrosine-independent inhibitory signaling by a killer cell Ig-like receptor cytoplasmic domain in human NK cells" (PDF). J. Immunol. 168 (10): 5047–57. doi:10.4049/jimmunol.168.10.5047. PMID 11994457. S2CID 35903264.
- Faure M, Long EO (2002). "KIR2DL4 (CD158d), an NK cell-activating receptor with inhibitory potential". J. Immunol. 168 (12): 6208–14. doi:10.4049/jimmunol.168.12.6208. PMID 12055234.
- Santourlidis S, Trompeter HI, Weinhold S, Eisermann B, Meyer KL, Wernet P, Uhrberg M (2002). "Crucial role of DNA methylation in determination of clonally distributed killer cell Ig-like receptor expression patterns in NK cells". J. Immunol. 169 (8): 4253–61. doi:10.4049/jimmunol.169.8.4253. PMID 12370356.
- Chan HW, Kurago ZB, Stewart CA, Wilson MJ, Martin MP, Mace BE, Carrington M, Trowsdale J, Lutz CT (2003). "DNA methylation maintains allele-specific KIR gene expression in human natural killer cells". J. Exp. Med. 197 (2): 245–55. doi:10.1084/jem.20021127. PMC 2193817. PMID 12538663.
- Becker S, Tonn T, Füssel T, Uhrberg M, Bogdanow M, Seifried E, Seidl C (2003). "Assessment of killer cell immunoglobulinlike receptor expression and corresponding HLA class I phenotypes demonstrates heterogenous KIR expression independent of anticipated HLA class I ligands". Hum. Immunol. 64 (2): 183–93. doi:10.1016/S0198-8859(02)00802-9. PMID 12559621.
- Gómez-Lozano N, de Pablo R, Puente S, Vilches C (2003). "Recognition of HLA-G by the NK cell receptor KIR2DL4 is not essential for human reproduction". Eur. J. Immunol. 33 (3): 639–44. doi:10.1002/eji.200323741. PMID 12616484. S2CID 29340524.
- Stewart CA, Van Bergen J, Trowsdale J (2003). "Different and divergent regulation of the KIR2DL4 and KIR3DL1 promoters". J. Immunol. 170 (12): 6073–81. doi:10.4049/jimmunol.170.12.6073. PMID 12794136.
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외부 링크
- PDBe-KB는 휴먼 킬러 세포 면역글로불린 유사 수용체 2DL4(KIR2DL4)에 대해 PDB에서 이용할 수 있는 모든 구조 정보의 개요를 제공한다.
이 기사는 공공영역에 있는 미국 국립 의학 도서관의 텍스트를 통합하고 있다.
