TNF 슈퍼패밀리의 분비단백질
종양괴사인자 슈퍼패밀리 멤버 14(TNFSF14 )라고도 알려진 LIGHT는 TNF 슈퍼패밀리의 [5] [6] [7] 분비 단백질이다.이는 헤르페스 바이러스 진입 매개체(HVEM)와 유인 수용체 3에 의해 인식된다.
명명법 LIGHT는 림프독소와 상동성을 나타내며 유도성 발현을 나타내며 T림프구에 발현 되는 수용체인 헤르페스바이러스 진입 매개체에 결합하기 위해 HSV 당단백 D와 경쟁한다. 차별화 용어집 에서는 CD258 로 분류됩니다.
기능. 이 유전자에 의해 암호화된 단백질은 종양괴사인자(TNF) 리간드 패밀리의 구성원이다. 이 단백질은 종양괴사인자 수용체 슈퍼패밀리의 일원인 TNFRSF14의 배위자이며 헤르페스바이러스 엔트리메디에이터(HVEM)로도 알려져 있다.다른 등형태를 코드하는 2개의 대체 스플라이스 전사 변이가 [6]
이 단백질은 림프세포의 활성화를 위한 늑장 자극 인자와 헤르페스 바이러스에 의한 감염을 억제하는 역할을 할 수 있다. 이 단백질은 T세포의 [8] [9] [10] 이 단백질은 또한 1차 [11]
상호 작용 LIGHT는 TNFRSF14 ,[12] [13] TNFRSF6B ,[12] [13] [14] BIRC2 ,[15] TRAF2 [15] [15] TRAF3 와 상호작용하는 것 으로 나타났습니다.
단순 헤르페스 바이러스의 역할 CD4가 HIV 감염의 주요 매개 수용체인 것과 마찬가지로 HSV 당단백질(gD )은 HVEM 수용체에 결합하며, HVEM 수용체는 TNFSF14/LIGHT에 의해 요구되어 LIGHT가 NFbB 경로를 활성화하는 능력을 낮춥니다.NFbB는 카스파아제8 을 저해하는 경로를 유발하는 아포토시스 억제를 돕는 생존인자이다. HSV의 gD가 HVEM에 결합하면 LIGHT는 비경쟁적으로 결합을 억제하여 감염된 [7]
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000125735 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000005824 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Mauri DN, Ebner R, Montgomery RI, Kochel KD, Cheung TC, Yu GL, Ruben S, Murphy M, Eisenberg RJ, Cohen GH, Spear PG, Ware CF (January 1998). "LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator" . Immunity . 8 (1): 21–30. doi :10.1016/S1074-7613(00)80455-0 PMID 9462508 . ^ a b "Entrez Gene: TNFSF14 tumor necrosis factor (ligand) superfamily, member 14" .^ a b Ware, Carl (2008). "Chapter 25: TNF-Related Cytokines in Immunity". In Paul, William (ed.). Fundamental Immunology 776 –801. 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The Journal of Biological Chemistry . 275 (19): 14307–15. doi :10.1074/jbc.275.19.14307 PMID 10799510 . Lama J, Ware CF (October 2000). "Human immunodeficiency virus type 1 Nef mediates sustained membrane expression of tumor necrosis factor and the related cytokine LIGHT on activated T cells" . Journal of Virology . 74 (20): 9396–402. doi :10.1128/JVI.74.20.9396-9402.2000 . PMC 112368 PMID 11000208 . Morel Y, Schiano de Colella JM, Harrop J, Deen KC, Holmes SD, Wattam TA, Khandekar SS, Truneh A, Sweet RW, Gastaut JA, Olive D, Costello RT (October 2000). "Reciprocal expression of the TNF family receptor herpes virus entry mediator and its ligand LIGHT on activated T cells: LIGHT down-regulates its own receptor" . Journal of Immunology . 165 (8): 4397–404. doi :10.4049/jimmunol.165.8.4397 PMID 11035077 . Zhang J, Salcedo TW, Wan X, Ullrich S, Hu B, Gregorio T, Feng P, Qi S, Chen H, Cho YH, Li Y, Moore PA, Wu J (June 2001). "Modulation of T-cell responses to alloantigens by TR6/DcR3" . The Journal of Clinical Investigation . 107 (11): 1459–68. doi :10.1172/JCI12159 . PMC 209323 PMID 11390428 . Granger SW, Butrovich KD, Houshmand P, Edwards WR, Ware CF (November 2001). "Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis" . Journal of Immunology . 167 (9): 5122–8. doi :10.4049/jimmunol.167.9.5122 PMID 11673523 . Shaikh RB, Santee S, Granger SW, Butrovich K, Cheung T, Kronenberg M, Cheroutre H, Ware CF (December 2001). "Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction" . Journal of Immunology . 167 (11): 6330–7. doi :10.4049/jimmunol.167.11.6330 PMID 11714797 . Bobik A, Kalinina N (December 2001). "Tumor necrosis factor receptor and ligand superfamily family members TNFRSF14 and LIGHT: new players in human atherogenesis" . 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인터류킨 TGFβ TNF 다른이들
