25I-NBF

25I-NBF
25I-NBF
25i-NBF.svg
임상자료
ATC 코드
  • 없는
법적현황
법적현황
  • DE: NpSG (산업 및 과학 전용)
  • UK: A급
식별자
  • 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-fluorophenyl)메틸]에탄-1-아민
CAS 번호
펍켐 CID
켐스파이더
CompTox 대시보드 (EPA)
화학 및 물리적 데이터
공식C17H19FINO2
어금질량415.247 g·1998−1
3D 모델(JSmol)
  • COc1cc(I)c(OC)cc1CC1CCNC2ccc2f
  • InChi=1S/C17H19FINO2/c1-21-16-10-15(19)17(19)9-12(16)7-8-20-11-5-3-4-6-14(13)18/h3-6,9-10,20H,7-8,11H2,1-2H3 checkY
  • 키:LPBKNBHMWRBPHT-UHFFFAOYSA-N checkY
☒NcheckY (이게 뭐야?) (iii)

25I-NBF(2C-I-NBF, NBF-2C-I, Cimbi-21)는 페네틸아민 환각제 2C-I의 파생물질로 인간 5HT2A 수용체에 매우 강력한 부분작용제 역할을 한다.[1][2][3] 그것은 양전자 방출 단층촬영(PET)을 사용하여 뇌에서 5-HT2A 수용체 분포를 매핑하기 위한 잠재적 리간드로 C방사선 형태로 연구되어 왔다.[4][5]

합법성

25I-NBF는 헝가리,[6] 일본,[7] 라트비아,[8] 버몬트에서 불법이다.[9]

스웨덴

The Riksdag added 25I-NBF to Narcotic Drugs Punishments Act under swedish schedule I ("substances, plant materials and fungi which normally do not have medical use") as of January 26, 2016, published by Medical Products Agency (MPA) in regulation HSLF-FS 2015:35 listed as 25I-NBF, and 2-(4-jodo-2,5-dimetoxifenyl)-N-(2-fluorobensyl)etanamin.[10]

영국

이 물질은 1971년 약물 오용법의 N-벤질페네틸아민 캐치-all 조항의 결과로 영국에서 A급 마약이다.[11]


아날로그 및 파생 모델

2C-I의 아날로그 및 파생 모델:

25I-NB*:

참조

  1. ^ Braden MR, Parrish JC, Naylor JC, Nichols DE (December 2006). "Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists". Molecular Pharmacology. 70 (6): 1956–64. doi:10.1124/mol.106.028720. PMID 17000863. S2CID 15840304.
  2. ^ Braden MR (2007). Towards a biophysical understanding of hallucinogen action (Ph.D. thesis). Purdue University. ProQuest 304838368.
  3. ^ Hansen M, Phonekeo K, Paine JS, Leth-Petersen S, Begtrup M, Bräuner-Osborne H, Kristensen JL (March 2014). "Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists". ACS Chemical Neuroscience. 5 (3): 243–9. doi:10.1021/cn400216u. PMC 3963123. PMID 24397362.
  4. ^ Hansen M (2010-12-16). Design and Synthesis of Selective Serotonin Receptor Agonists for Positron Emission Tomography Imaging of the Brain (Ph.D. thesis). University of Copenhagen. doi:10.13140/RG.2.2.33671.14245.
  5. ^ Ettrup A, Hansen M, Santini MA, Paine J, Gillings N, Palner M, et al. (April 2011). "Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT (2A) agonist PET tracers". European Journal of Nuclear Medicine and Molecular Imaging. 38 (4): 681–93. doi:10.1007/s00259-010-1686-8. PMID 21174090. S2CID 12467684.
  6. ^ "A Magyarországon megjelent, a Kábítószer és Kábítószer-függőség Európai Megfigyelő Központjának Korai Jelzőrendszerébe (EMCDDA EWS) 2005 óta bejelentett ellenőrzött anyagok büntetőjogi vonatkozású besorolása" [Criminal classification of controlled substances published in Hungary and notified to the European Monitoring Center for Drugs and Drug Addiction (EMCDDA EWS) since 2005] (PDF) (in Hungarian).
  7. ^ "指定薬物名称・構造式一覧（平成27年9月16日現在）" (PDF) (in Japanese). 厚生労働省. 16 September 2015. Retrieved 8 October 2015.
  8. ^ "Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem" [Regulations on Narcotic Drugs, Psychotropic Substances and Precursors Controlled in Latvia]. Ministry of Health of the Republic of Latvia (in Latvian). Archived from the original on 2016-03-04. Retrieved 2015-10-15.
  9. ^ "Regulated Drugs Rule" (PDF). Vermont Department of Health. Retrieved 14 October 2015.
  10. ^ Ödman P. "Gemensamma författningssamlingen avseende hälso- och sjukvård, socialtjänst, läkemedel, folkhälsa m.m." [Joint constitutional collection on health care, social services, pharmaceuticals, public health, etc.] (PDF). Lakemedelsverket (in Swedish).
  11. ^ "The Misuse of Drugs Act 1971 (Ketamine etc.) (Amendment) Order 2014". www.legislation.gov.uk.