프루반세린

Pruvanserin
프루반세린
Pruvanserin.png
임상자료
경로:
행정		구강
ATC 코드
  • 없는
법적현황
법적현황
  • 일반적으로: 통제되지 않음
식별자
  • 7-({4-[2-[4-fluorophenyl)ethyl]piperazin-1-yl}yl}carbonyl)-1H-indole-3-carbonitrile.
CAS 번호
펍켐 CID
켐스파이더
유니
켐벨
CompTox 대시보드 (EPA)
화학 및 물리적 데이터
공식C22H21FN4O
어금질량376.435 g·190−1
3D 모델(JSmol)
  • N#Cc2c1ccc(c1[nH]c2)C(=O)N4CCN(CCC3ccc(F)cc3)CC4

프루반세린(EMD-281,014, LY-2422,347)은 일라이 릴리와 컴퍼니가 불면증 치료를 위해 개발 중인 선택적 5HT2A 수용체 길항제다.[1][2] 2008년 임상 2상이었지만 더 이상 회사 개발 파이프라인에 있지 않아 단종된 것으로 보인다.[3][4] 프뤼반세린은 수면 개선 특성 외에도 동물 연구에서 항우울제, 항불안제, 작업 기억력 향상 효과가 있는 것으로 나타났다.[5][6][7][8][9]

참고 항목

참조

  1. ^ Bartoszyk GD, van Amsterdam C, Böttcher H, Seyfried CA (July 2003). "EMD 281014, a new selective serotonin 5-HT2A receptor antagonist". European Journal of Pharmacology. 473 (2–3): 229–30. doi:10.1016/S0014-2999(03)01992-7. PMID 12892843.
  2. ^ Teegarden BR, Al Shamma H, Xiong Y (2008). "5-HT(2A) inverse-agonists for the treatment of insomnia". Current Topics in Medicinal Chemistry. 8 (11): 969–76. doi:10.2174/156802608784936700. PMID 18673166.
  3. ^ "Efficacy Study of LY2422347 to Treat Insomnia - Full Text View - ClinicalTrials.gov". 24 January 2007. {{cite journal}}: Cite 저널은 필요로 한다. journal= (도움말)
  4. ^ "Eli Lilly and Company » Research Pipeline".
  5. ^ Monti JM, Jantos H (September 2006). "Effects of activation and blockade of 5-HT2A/2C receptors in the dorsal raphe nucleus on sleep and waking in the rat". Progress in Neuro-psychopharmacology & Biological Psychiatry. 30 (7): 1189–95. doi:10.1016/j.pnpbp.2006.02.013. PMID 16713054. S2CID 12837755.
  6. ^ Monti JM, Jantos H (December 2006). "Effects of the serotonin 5-HT2A/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213, respectively, on sleep and waking in the rat". European Journal of Pharmacology. 553 (1–3): 163–70. doi:10.1016/j.ejphar.2006.09.027. PMID 17059817.
  7. ^ Patel JG, Bartoszyk GD, Edwards E, Ashby CR (April 2004). "The highly selective 5-hydroxytryptamine (5-HT)2A receptor antagonist, EMD 281014, significantly increases swimming and decreases immobility in male congenital learned helpless rats in the forced swim test". Synapse. 52 (1): 73–5. doi:10.1002/syn.10308. PMID 14755634. S2CID 21941333.
  8. ^ Adamec R, Creamer K, Bartoszyk GD, Burton P (November 2004). "Prophylactic and therapeutic effects of acute systemic injections of EMD 281014, a selective serotonin 2A receptor antagonist on anxiety induced by predator stress in rats". European Journal of Pharmacology. 504 (1–2): 79–96. doi:10.1016/j.ejphar.2004.09.017. PMID 15507224.
  9. ^ Terry AV, Buccafusco JJ, Bartoszyk GD (June 2005). "Selective serotonin 5-HT2A receptor antagonist EMD 281014 improves delayed matching performance in young and aged rhesus monkeys". Psychopharmacology. 179 (4): 725–32. doi:10.1007/s00213-004-2114-1. PMID 15619109. S2CID 30366683.