로60-0175번길

로60-0175번길
식별자
	IUPAC 이름 (S)-6-클로로-5-플루오로-1H-indole-2-propaminine;
CAS 번호	169675-09-6;
펍켐 CID	3045227;
IUPHAR/BPS	274;
켐스파이더	2308002;
체비	CHEBI:142183;
ECHA InfoCard	100.189.524
화학 및 물리적 데이터
공식	C11H12CLFN2
어금질량	226.68 g·1998−1
3D 모델(JSmol)	인터랙티브 이미지;
	스마일즈 C[C@@H](Cn1ccc2c1cc(c(c(2)F)Cl)Cl)n;
	인치 InChi=1S/C11H12ClFN2/c1-7(14)6-15-3-2-8-4-10(13)9(13)9-11(8)15/h2-5,7H2,14H2,1H3/t7/m0/s1; 키:XJZQXUGLLXTHO-ZETCQYMHSA-N;
	(iii)

Ro60-0175는 호프만-라 로슈가 개발한 약으로 과학 연구에 응용이 가능하다.^[1]^[2] 5-HT_2B 및 5-HT_2C 세로토닌 수용체 하위유형 모두에 대해 강력하고 선택적인 작용제로 작용하며, 밀접하게 연관된_2A 5-HT 하위유형에 비해 선택성이 우수하며, 다른 수용체에는 친화력이 거의 또는 전혀 없다.^[3]^[4]

참고 항목

참조

^ Quarta D, Naylor CG, Stolerman IP (August 2007). "The serotonin 2C receptor agonist Ro-60-0175 attenuates effects of nicotine in the five-choice serial reaction time task and in drug discrimination". Psychopharmacology. 193 (3): 391–402. doi:10.1007/s00213-007-0802-3. PMID 17473916. S2CID 21020653.
^ Fletcher PJ, Rizos Z, Sinyard J, Tampakeras M, Higgins GA (May 2008). "The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues". Neuropsychopharmacology. 33 (6): 1402–12. doi:10.1038/sj.npp.1301509. PMID 17653111.
^ Porter RH, Benwell KR, Lamb H, Malcolm CS, Allen NH, Revell DF, et al. (September 1999). "Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells". British Journal of Pharmacology. 128 (1): 13–20. doi:10.1038/sj.bjp.0702751. PMC 1571597. PMID 10498829.
^ Damjanoska KJ, Muma NA, Zhang Y, D'Souza DN, Garcia F, Carrasco GA, et al. (March 2003). "Neuroendocrine evidence that (S)-2-(chloro-5-fluoro-indol- l-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine(2C) receptor agonist". The Journal of Pharmacology and Experimental Therapeutics. 304 (3): 1209–16. doi:10.1124/jpet.102.043489. PMID 12604698. S2CID 23880629.

신경계통에 관한 이 약물 기사는 단조롭다. 위키피디아를 확장하여 도울 수 있다.

[1] Quarta D, Naylor CG, Stolerman IP (August 2007). "The serotonin 2C receptor agonist Ro-60-0175 attenuates effects of nicotine in the five-choice serial reaction time task and in drug discrimination". Psychopharmacology. 193 (3): 391–402. doi:10.1007/s00213-007-0802-3. PMID 17473916. S2CID 21020653.

[2] Fletcher PJ, Rizos Z, Sinyard J, Tampakeras M, Higgins GA (May 2008). "The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues". Neuropsychopharmacology. 33 (6): 1402–12. doi:10.1038/sj.npp.1301509. PMID 17653111.

[3] Porter RH, Benwell KR, Lamb H, Malcolm CS, Allen NH, Revell DF, et al. (September 1999). "Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells". British Journal of Pharmacology. 128 (1): 13–20. doi:10.1038/sj.bjp.0702751. PMC 1571597. PMID 10498829.

[4] Damjanoska KJ, Muma NA, Zhang Y, D'Souza DN, Garcia F, Carrasco GA, et al. (March 2003). "Neuroendocrine evidence that (S)-2-(chloro-5-fluoro-indol- l-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine(2C) receptor agonist". The Journal of Pharmacology and Experimental Therapeutics. 304 (3): 1209–16. doi:10.1124/jpet.102.043489. PMID 12604698. S2CID 23880629.

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로60-0175번길

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참고 항목

참조

식별자

IUPAC 이름 (S)-6-클로로-5-플루오로-1H-indole-2-propaminine
CAS 번호	169675-09-6
펍켐 CID	3045227
IUPHAR/BPS	274
켐스파이더	2308002
체비	CHEBI:142183
ECHA InfoCard	100.189.524
화학 및 물리적 데이터
공식	C₁₁H₁₂CLFN₂
어금질량	226.68 g·1998⁻¹
3D 모델(JSmol)	인터랙티브 이미지
스마일즈 C[C@@H](Cn1ccc2c1cc(c(c(2)F)Cl)Cl)n
인치 InChi=1S/C11H12ClFN2/c1-7(14)6-15-3-2-8-4-10(13)9(13)9-11(8)15/h2-5,7H2,14H2,1H3/t7/m0/s1 키:XJZQXUGLLXTHO-ZETCQYMHSA-N
(iii)