인도렌산염

Indorenate
인도렌산염
Indorenate Structure.svg
식별자
  • 메틸 3-아미노-2-(5-메톡시-1H-인돌-3-yl)프로파노산염
CAS 번호
펍켐 CID
켐스파이더
유니
CompTox 대시보드 (EPA)
화학 및 물리적 데이터
공식C13H16N2O3
어금질량248.282 g·2012−1
3D 모델(JSmol)
  • COC(=O)C(CN)c1c[nH]cc(cc2OC)c1c2
  • InChi=1S/C13H16N2O3/c1-17-8-8-4-12-9(5-8)11(7-15-12)10(6-14)13(16)18-2/h3-5,7,10,15H,6,14H2,1-2H3 ☒N
  • 키:YFEDJMLMWJSRJ-UHFFFAOYSA-N ☒N
☒NcheckY (이게 뭐야?) (iii)

인도렌산염(TR-3369)은 트립타민 유도체로 5-HT1A1B, 5-HT2C, 5-HT 세로토닌 수용체에서 작용제 역할을 한다. 주로 5-HT에서의1A 행동을 통해 불안, 고혈압, 식욕부진, 식욕부진 등의 영향을 미치지만, 5-HT1B 및 5-HT2C 하위 유형의 일부 기여와 함께 일부 다른 비-세로토네르기 대상도 있다.[1][2][3][4][5][6][7][8][9]

참고 항목

참조

  1. ^ Antonaccio MJ, Kerwin L (1981). "On the effects and mechanism of action of the antihypertensive agent TR 3369 (5-methoxytryptamine beta-methylcarboxylate) in spontaneously hypertensive rats". Journal of Cardiovascular Pharmacology. 3 (6): 1306–11. doi:10.1097/00005344-198111000-00018. PMID 6173531. S2CID 53762649.
  2. ^ Schoeffter P, Hoyer D (November 1988). "Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus". British Journal of Pharmacology. 95 (3): 975–85. doi:10.1111/j.1476-5381.1988.tb11728.x. PMC 1854240. PMID 3207999.
  3. ^ Fernández-Guasti A, Escalante A, Hong E, Agmo A (September 1990). "Behavioural actions of the serotonergic anxiolytic indorenate". Pharmacology Biochemistry and Behavior. 37 (1): 83–8. doi:10.1016/0091-3057(90)90045-J. PMID 1979877. S2CID 22146281.
  4. ^ López Cabrera M, Velázquez Martínez DN, Prado R, García G, Ortiz R (1991). "Effects of the intracerebroventricular administration of indorenate and fenfluramine on spontaneous behavior and food intake in rats". Proceedings of the Western Pharmacology Society. 34: 465–8. PMID 1788330.
  5. ^ Velázquez-Martínez DN, López Cabrera M, Sánchez H, Ramírez JI, Hong E (March 1999). "Discriminative stimulus properties of indorenate, a serotonin agonist". Journal of Psychiatry & Neuroscience. 24 (2): 122–30. PMC 1188992. PMID 10212554.
  6. ^ Sánchez H, Velázquez-Martínez DN (March 2001). "Discriminative stimulus properties of indorenate, a 5-HT1A, 5-HT1B and 5-HT2C agonist: a study in rats". Journal of Psychopharmacology (Oxford, England). 15 (1): 29–36. doi:10.1177/026988110101500106. PMID 11277605. S2CID 13257797.
  7. ^ Miranda F, Orozco G, Velázquez-Martínez DN (July 2002). "Full substitution of the discriminative cue of a 5-HT(1A/1B/2C) agonist with the combined administration of a 5-HT(1B/2C) and a 5-HT(1A) agonist". Behavioural Pharmacology. 13 (4): 303–11. doi:10.1097/00008877-200207000-00007. PMID 12218511. S2CID 24468773.
  8. ^ Miranda F, Hong E, Sánchez H, Velázquez-Martínez DN (January 2003). "Further evidence that the discriminative stimulus properties of indorenate are mediated by 5-HT 1A/1B/2C receptors". Pharmacology Biochemistry and Behavior. 74 (2): 371–80. doi:10.1016/S0091-3057(02)01010-9. PMID 12479957. S2CID 23429292.
  9. ^ López-Meraz ML, Neri-Bazán L, Rocha L (September 2006). "Indorenate modifies a1-adrenergic and benzodiazepine receptor binding in the rat brain: an autoradiography study". The Journal of Pharmacy and Pharmacology. 58 (9): 1243–8. doi:10.1211/jpp.58.9.0011. PMID 16945183. S2CID 44723130.


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