클로로페닐비구아나이드

클로로페닐비구아나이드
식별자
	IUPAC 이름 2-(3-클로로페닐)-1-((inomethylidene)guanidine;
CAS 번호	48144-44-1 ;
펍켐 CID	1354;
IUPHAR/BPS	2287;
켐스파이더	27570 ;
유니	910A4X901V;
켐벨	켐블42752 ;
CompTox 대시보드 (EPA)	DTXSID70197436 ;
화학 및 물리적 데이터
공식	C8H12CLN5
어금질량	213.67 g·190−1
3D 모델(JSmol)	인터랙티브 이미지;
	스마일즈 c1ccc(Cl)cc1NC(=N)NC(=N)n;
	인치 InChi=1S/C8H10ClN5/c9-5-3-1-2-4-6(5)13-8(12)14-7(10)11/h1-4H, (H6,10,11,12,13,14) ; 키:MKWFJPZMYHPQIA-UHFFFAOYSA-N ;
	(iii)

메타-클로로페닐비구아나이드(1-(3-Clorophenylbiguanide, m-CPBG)는 5-HT₃ 수용체의^[1]^[2]^[3] 알로스테리 작용제 및 조절제이며 α-아드레날린_2A 수용체의 길항제다.^[4] 그것은 동물 연구에서 음시 유발, 에메틱, 저체온증을 가지고 있다.^[5]^[6]^[7]^[8]

참고 항목

참조

^ Miles TF, Lester HA, Dougherty DA (2015). "Allosteric activation of the 5-HT3AB receptor by mCPBG". Neuropharmacology. 91: 103–8. doi:10.1016/j.neuropharm.2014.12.018. PMC 4312754. PMID 25541413.
^ Michaelson SD, Paulsen IM, Kozuska JL, Martin IL, Dunn SM (2013). "Importance of recognition loops B and D in the activation of human 5-HT₃ receptors by 5-HT and meta-chlorophenylbiguanide". Neuropharmacology. 73: 398–403. doi:10.1016/j.neuropharm.2013.06.017. PMID 23810831.
^ Suryanarayanan A, Joshi PR, Bikádi Z, Mani M, Kulkarni TR, Gaines C, Schulte MK (2005). "The loop C region of the murine 5-HT3A receptor contributes to the differential actions of 5-hydroxytryptamine and m-chlorophenylbiguanide". Biochemistry. 44 (25): 9140–9. doi:10.1021/bi050661e. PMID 15966738.
^ Schlicker E, Kathmann M, Exner HJ, Detzner M, Göthert M (1994). "the 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide facilitates noradrenaline release by blockade of alpha 2-adrenoceptors in the mouse brain cortex". Naunyn-Schmiedeberg's Archives of Pharmacology. 349 (1): 20–24. doi:10.1007/bf00178201. PMID 7908122.
^ Andrews N, File SE (1992). "Are there changes in sensitivity to 5-HT3 receptor ligands following chronic diazepam treatment?". Psychopharmacology. 108 (3): 333–7. doi:10.1007/BF02245120. PMID 1523283.
^ Dukat M, Young R, Darmani NN, Ahmed B, Glennon RA (June 2000). "The 5-HT3 agent N-(3-chlorophenyl)guanidine (MD-354) serves as a discriminative stimulus in rats and displays partial agonist character in a shrew emesis assay". Psychopharmacology. 150 (2): 200–7. doi:10.1007/s002130000410. PMID 10907673.
^ Castro L, Varjão B, Maldonado I, Campos I, Duque B, Fregoneze J, Reis de Oliveira I, De Castro-e-Silva E (November 2002). "Central 5-HT(3) receptors and water intake in rats". Physiology & Behavior. 77 (2–3): 349–59. doi:10.1016/S0031-9384(02)00872-7. PMID 12419412.
^ Naumenko VS, Kondaurova EM, Popova NK (November 2009). "Central 5-HT3 receptor-induced hypothermia in mice: interstrain differences and comparison with hypothermia mediated via 5-HT1A receptor". Neuroscience Letters. 465 (1): 50–4. doi:10.1016/j.neulet.2009.09.005. PMID 19735696.

외부 링크

위키미디어 커먼스의 클로로페닐비구아나이드 관련 매체

신경계통에 관한 이 약물 기사는 단조롭다. 위키피디아를 확장하여 도울 수 있다.

[pmid25541413-1] Miles TF, Lester HA, Dougherty DA (2015). "Allosteric activation of the 5-HT3AB receptor by mCPBG". Neuropharmacology. 91: 103–8. doi:10.1016/j.neuropharm.2014.12.018. PMC 4312754. PMID 25541413.

[pmid23810831-2] Michaelson SD, Paulsen IM, Kozuska JL, Martin IL, Dunn SM (2013). "Importance of recognition loops B and D in the activation of human 5-HT₃ receptors by 5-HT and meta-chlorophenylbiguanide". Neuropharmacology. 73: 398–403. doi:10.1016/j.neuropharm.2013.06.017. PMID 23810831.

[pmid15966738-3] Suryanarayanan A, Joshi PR, Bikádi Z, Mani M, Kulkarni TR, Gaines C, Schulte MK (2005). "The loop C region of the murine 5-HT3A receptor contributes to the differential actions of 5-hydroxytryptamine and m-chlorophenylbiguanide". Biochemistry. 44 (25): 9140–9. doi:10.1021/bi050661e. PMID 15966738.

[pmid7908122-4] Schlicker E, Kathmann M, Exner HJ, Detzner M, Göthert M (1994). "the 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide facilitates noradrenaline release by blockade of alpha 2-adrenoceptors in the mouse brain cortex". Naunyn-Schmiedeberg's Archives of Pharmacology. 349 (1): 20–24. doi:10.1007/bf00178201. PMID 7908122.

[pmid1523283-5] Andrews N, File SE (1992). "Are there changes in sensitivity to 5-HT3 receptor ligands following chronic diazepam treatment?". Psychopharmacology. 108 (3): 333–7. doi:10.1007/BF02245120. PMID 1523283.

[pmid10907673-6] Dukat M, Young R, Darmani NN, Ahmed B, Glennon RA (June 2000). "The 5-HT3 agent N-(3-chlorophenyl)guanidine (MD-354) serves as a discriminative stimulus in rats and displays partial agonist character in a shrew emesis assay". Psychopharmacology. 150 (2): 200–7. doi:10.1007/s002130000410. PMID 10907673.

[pmid12419412-7] Castro L, Varjão B, Maldonado I, Campos I, Duque B, Fregoneze J, Reis de Oliveira I, De Castro-e-Silva E (November 2002). "Central 5-HT(3) receptors and water intake in rats". Physiology & Behavior. 77 (2–3): 349–59. doi:10.1016/S0031-9384(02)00872-7. PMID 12419412.

[pmid19735696-8] Naumenko VS, Kondaurova EM, Popova NK (November 2009). "Central 5-HT3 receptor-induced hypothermia in mice: interstrain differences and comparison with hypothermia mediated via 5-HT1A receptor". Neuroscience Letters. 465 (1): 50–4. doi:10.1016/j.neulet.2009.09.005. PMID 19735696.

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클로로페닐비구아나이드

네임스페이스

더

참고 항목

참조

외부 링크

식별자

IUPAC 이름 2-(3-클로로페닐)-1-((inomethylidene)guanidine
CAS 번호	48144-44-1^Y
펍켐 CID	1354
IUPHAR/BPS	2287
켐스파이더	27570^Y
유니	910A4X901V
켐벨	켐블42752^Y
CompTox 대시보드 (EPA)	DTXSID70197436
화학 및 물리적 데이터
공식	C₈H₁₂CLN₅
어금질량	213.67 g·190⁻¹
3D 모델(JSmol)	인터랙티브 이미지
스마일즈 c1ccc(Cl)cc1NC(=N)NC(=N)n
인치 InChi=1S/C8H10ClN5/c9-5-3-1-2-4-6(5)13-8(12)14-7(10)11/h1-4H, (H6,10,11,12,13,14)^Y 키:MKWFJPZMYHPQIA-UHFFFAOYSA-N^Y
(iii)