SB-204741

SB-204741
SB-204741
SB-204,741 structure.png
임상자료
기타 이름SB-204,741
식별자
  • N-(1-메틸-1H-인돌-5-yl)-N'-(3-메틸이소티아졸-5-yl)urea
CAS 번호
펍켐 CID
IUPHAR/BPS
켐스파이더
체비
CompTox 대시보드 (EPA)
ECHA InfoCard100.150.276 Edit this at Wikidata
화학 및 물리적 데이터
공식C14H14N4OS
어금질량286.35 g·190−1
3D 모델(JSmol)
  • c2c(C)nsc2NC(=O)Nc3ccc1n(C)cc1c3
  • InChi=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18-2/h3-8H,1-2H3, (H2,15,16,19)
  • 키:USFFHFFQWXDVMH-UHFFFAOYSA-N
(iii)

SB-204741은 세로토닌 5-HT2B 수용체에서 강력한 선택적 길항제 역할을 하는 약물로, 밀접하게 연관된 5-HT2C 수용체보다 약 135배 선택성이 있으며, 5-HT2A 수용체 및 기타 표적보다 더 높다.[1] 5-HT2B 수용체의 기능을 조사하기 위한 과학적 연구에 사용된다.[2][3][4][5]

참조

  1. ^ Forbes IT, Jones GE, Murphy OE, Holland V, Baxter GS (March 1995). "N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: a novel, high-affinity 5-HT2B receptor antagonist". Journal of Medicinal Chemistry. 38 (6): 855–7. doi:10.1021/jm00006a001. PMID 7699699.
  2. ^ Glusa E, Pertz HH (June 2000). "Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT(2B) receptors". British Journal of Pharmacology. 130 (3): 692–8. doi:10.1038/sj.bjp.0703341. PMC 1572101. PMID 10821800.
  3. ^ Holohean AM, Hackman JC (October 2004). "Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones". British Journal of Pharmacology. 143 (3): 351–60. doi:10.1038/sj.bjp.0705935. PMC 1575347. PMID 15339859.
  4. ^ Papageorgiou A, Denef C (September 2007). "Stimulation of growth hormone release by 5-hydroxytryptamine (5-HT) in cultured rat anterior pituitary cell aggregates: evidence for mediation by 5-HT2B, 5-HT7, 5-HT1B, and ketanserin-sensitive receptors". Endocrinology. 148 (9): 4509–22. doi:10.1210/en.2007-0034. PMID 17584957.
  5. ^ Wouters MM, Gibbons SJ, Roeder JL, Distad M, Ou Y, Strege PR, et al. (September 2007). "Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors" (PDF). Gastroenterology. 133 (3): 897–906. doi:10.1053/j.gastro.2007.06.017. PMID 17854596.
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