메피프라졸
Mepiprazole | |
| 임상 데이터 | |
|---|---|
| 상호 | 시고다루 |
| 기타 이름 | PAP, EMD-16923, H-4007 |
| 루트 행정부. | 오랄 |
| ATC 코드 |
|
| 법적 상태 | |
| 법적 상태 |
|
| 식별자 | |
| |
| CAS 번호 |
|
| PubChem CID | |
| 켐스파이더 | |
| 유니 | |
| CompTox 대시보드 (EPA ) | |
| 화학 및 물리 데이터 | |
| 공식 | C16H21클론N4 |
| 몰 질량 | 304.82 g/120−1 |
| 3D 모델(JSmol) | |
| |
메피프라졸(INN, BAN)(브랜드명 프시고달)은 스페인에서 [2][3][4][5][6]시판되는 추가적인 항우울제 특성을[1] 가진 페닐피페라진 그룹의 항불안제 약물이다.5-HT2A 및 α-아드레날린1 수용체[7][8][9] 길항제로서 작용하며 재흡수를 억제하고 세로토닌, 도파민, 노르에피네프린의 다양한 [1][9]범위로 방출을 유도하며 세로토닌 길항제 및 재흡수 억제제(SARI)[10]로 기술되어 있다.과민성대장증후군(IBS) 환자에서 메피프라졸의 통제된 임상시험도 수행되었으며 일부 [11]환자에서 IBS 증상을 완화시키는 약물의 이점을 제안했다.트라조돈, 네파조돈 및 에토페리돈과 같은 다른 페닐피페라진과 유사하게 메피프라졸은 활성 [12]대사물로서 mCPP를 생성한다.
「 」를 참조해 주세요.
레퍼런스
- ^ a b Placheta P, Singer E, Kriwanek W, Hertting G (August 1976). "Mepiprazole, a new psychotropic drug: effects on uptake and retention of monoamines in rat brain synaptosomes". Psychopharmacology. 48 (3): 295–301. doi:10.1007/BF00496865. PMID 9660. S2CID 9194743.
- ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 768–. ISBN 978-1-4757-2085-3.
- ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.
- ^ Pöldinger W (1975). "Clinical trial of 3-methyl-5-(beta-N'-(N-m-chlorophenylpiperazino)ethyl)-pyrazole dihydrochloride (Mepiprazol) in the therapy of psychovegetative disorders". International Pharmacopsychiatry. 10 (1): 1–8. doi:10.1159/000468162. PMID 1095510.
- ^ De Buck R, Van Durme R, Pelc I (May 1975). "[A controlled double-blind crossover study of the efficacy of mepiprazol (EMD 16.923) and of diazepam in the treatment of neurotic disorders]". Acta Psychiatrica Belgica (in French). 75 (3): 320–33. PMID 769484.
- ^ Saldaña Hernández OH, Hernández González J (1976). "[Psychopharmological research with EMD 16-923 in patients with different degrees of anxiety]". Neurología, Neurocirugía, Psiquiatría (in Spanish). 17 (1): 29–33. PMID 1052713.
- ^ Cohen ML, Fuller RW, Kurz KD (1983). "Evidence that blood pressure reduction by serotonin antagonists is related to alpha receptor blockade in spontaneously hypertensive rats". Hypertension. 5 (5): 676–81. doi:10.1161/01.hyp.5.5.676. PMID 6311738.
- ^ Maj J, Sypniewska M (1980). "Central action of mepiprazole". Polish Journal of Pharmacology and Pharmacy. 32 (4): 475–84. PMID 7255266.
- ^ a b Fuxe K, Agnati LF, Ungerstedt U (January 1976). "The effect of mepiprazole on central monoamine neurons. Evidence for increased 5-hydroxytryptamine and dopamine receptor activity". European Journal of Pharmacology. 35 (1): 93–108. doi:10.1016/0014-2999(76)90304-6. PMID 943291.
- ^ Fagiolini, Andrea; Comandini, Alessandro; Dell’Osso, Mario Catena; Kasper, Siegfried (2012). "Rediscovering Trazodone for the Treatment of Major Depressive Disorder". CNS Drugs. 26 (12): 1033–1049. doi:10.1007/s40263-012-0010-5. ISSN 1172-7047. PMC 3693429. PMID 23192413.
- ^ Dotevall G, Groll E (October 1974). "Controlled clinical trial of mepiprazole in irritable bowel syndrome". The British Medical Journal. 4 (5935): 16–8. doi:10.1136/bmj.4.5935.16. PMC 1612118. PMID 4609545.
- ^ Fong MH, Garattini S, Caccia S (October 1982). "1-m-Chlorophenylpiperazine is an active metabolite common to the psychotropic drugs trazodone, etoperidone and mepiprazole". The Journal of Pharmacy and Pharmacology. 34 (10): 674–5. doi:10.1111/j.2042-7158.1982.tb04701.x. PMID 6128394. S2CID 44968564.
