DPI-3290

DPI-3290
DPI-3290
DPI-3290.svg
식별자
  • 3-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-hydroxypenyl)메틸]-N-(3-fluorophenyl)-N-Methylbenzamide
CAS 번호
  • 182417-73-8 ☒N
펍켐 CID
켐스파이더
유니
켐벨
화학 및 물리적 데이터
공식C30H34FN3O2
어금질량487.619 g·19−1.
3D 모델(JSmol)
  • C[C@H]1CN([C@@H](CN1[C@@H](C2=CC(=CC=C2)O)C3=CC=CC(=C3)C(=O)N(C)C4=CC(=CC=C4)F)C)CC=C
  • InChi=1S/C30H34FN3O2/c1-5-15-33-19-22(3)34(20-21(33)2)29(24-10-7-14-28(35)17-24)23-9-6-11-25(16-23)30(36)32(4)27-13-8-12-26(31)18-27/h5-14,16-18,21-22,29,35H,1,15,19-20H2,2-4H3/t21-,22+,29-/m1/s1 ☒N
  • 키:LZXRQLIMYJZDA-UETOGOEVSA-N ☒N
☒NcheckY (이게 뭐야?) (iii)

DPI-3290은 버로우스 웰컴의 과학자들에 의해 발견되어 델타 제약사에 허가를 받았으며 과학 연구에 사용되는 약물이다. 이것은 강력한 진통제로 호흡기 우울증을 거의 일으키지 않는다.[2][3]

DPI-3290은 μ-와 Δ-opioid 수용체 모두에서 작용제 역할을 하며, IC50은 μ에 6.2nM, 1.0nM이다.[4]

참고 항목

참조

  1. ^ 미국 특허 5552404 - 오피오이드 화합물 및 사용 방법
  2. ^ Gengo PJ, Pettit HO, O'Neill SJ, Wei K, McNutt R, Bishop MJ, Chang KJ (December 2003). "DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. I. A mixed opioid agonist with potent antinociceptive activity". The Journal of Pharmacology and Experimental Therapeutics. 307 (3): 1221–6. doi:10.1124/jpet.103.054361. PMID 14534368. S2CID 93569860.
  3. ^ Gengo PJ, Pettit HO, O'Neill SJ, Su YF, McNutt R, Chang KJ (December 2003). "DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. II. A mixed opioid agonist with potent antinociceptive activity and limited effects on respiratory function". The Journal of Pharmacology and Experimental Therapeutics. 307 (3): 1227–33. doi:10.1124/jpet.103.054429. PMID 14534367. S2CID 45159720.
  4. ^ Ananthan S (March 2006). "Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics". The AAPS Journal. 8 (1): E118-25. doi:10.1208/aapsj080114. PMC 2751430. PMID 16584118.