SNAP-94847
SNAP-94847식별자 | |
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켐스파이더 | |
ECHA InfoCard | 100.230.605 |
화학 및 물리적 데이터 | |
공식 | C29H32F2N2O2 |
어금질량 | 478.572 g·1998−1 |
3D 모델(JSmol) | |
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(iii) |
SNAP-94847은 멜라닌 농축 호르몬 수용체 MCH의1 선택적 비펩타이드 길항제인 과학연구에 사용되는 약물로, 동물 연구에서는 항불안제와 항우울제 효과를 동시에 발생시키는 것으로 나타났으며,[1][2] 또한 식중독의 가능성을 시사하는 식품소비를 감소시키는 것으로 나타났다.[3]null
참조
- ^ David DJ, Klemenhagen KC, Holick KA, Saxe MD, Mendez I, Santarelli L, Craig DA, Zhong H, Swanson CJ, Hegde LG, Ping XI, Dong D, Marzabadi MR, Gerald CP, Hen R (April 2007). "Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis". The Journal of Pharmacology and Experimental Therapeutics. 321 (1): 237–48. doi:10.1124/jpet.106.109678. PMID 17237257. S2CID 717425.
- ^ Smith DG, Hegde LG, Wolinsky TD, Miller S, Papp M, Ping X, Edwards T, Gerald CP, Craig DA (February 2009). "The effects of stressful stimuli and hypothalamic-pituitary-adrenal axis activation are reversed by the melanin-concentrating hormone 1 receptor antagonist SNAP 94847 in rodents". Behavioural Brain Research. 197 (2): 284–91. doi:10.1016/j.bbr.2008.08.026. PMID 18793675. S2CID 205878561.
- ^ Nair SG, Adams-Deutsch T, Pickens CL, Smith DG, Shaham Y (July 2009). "Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats". Psychopharmacology. 205 (1): 129–40. doi:10.1007/s00213-009-1523-6. PMC 3143407. PMID 19340414.