SNAP-7941

SNAP-7941
SNAP-7941
SNAP-7941 structure.png
식별자
켐벨
화학 및 물리적 데이터
공식C33H41F2N5O6
어금질량641.704 g·migration−1
3D 모델(JSmol)
  • CC(C)C(=O)Nc(c4)ccc4C3CCN(CC3)CCNC(=O)N(C(=O)N(=O)N(C)NC=1COC(C=1C(=O)OC)ccc2f
☒NcheckY (이게 뭐야?) (iii)

SNAP-7941는 약물은 멜라닌 호르몬 수용체 MCH1 집중하고 때는 선택적,non-peptide 길항 물질 과학적 연구 결과에서 사용했다.초기 동물 연구에서지만 후속 재판 결과와 SNAP-7941의 주요 중요성은 납 화합물. 있disappointing,[3]다 유망한, 항우울제와 식욕을 감퇴시키는 effects,[1][2]불안을 완화하는 있었다.MCH1 수용체의 기능에 대한 연구에 계속 사용되지만,[4][5] SNAP-94847과 같은 보다 강력하고 선택적인 길항제들이 개발되었다.[6][7]null

참조

  1. ^ Borowsky B, Durkin MM, Ogozalek K, Marzabadi MR, DeLeon J, Lagu B, Heurich R, Lichtblau H, Shaposhnik Z, Daniewska I, Blackburn TP, Branchek TA, Gerald C, Vaysse PJ, Forray C (August 2002). "Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist". Nature Medicine. 8 (8): 825–30. doi:10.1038/nm741. PMID 12118247.
  2. ^ Doggrell SA (June 2003). "Does the melanin-concentrating hormone antagonist SNAP-7941 deserve 3As?". Expert Opinion on Investigational Drugs. 12 (6): 1035–8. doi:10.1517/13543784.12.6.1035. PMID 12783607. S2CID 13219655.
  3. ^ Basso AM, Bratcher NA, Gallagher KB, Cowart MD, Zhao C, Sun M, Esbenshade TA, Brune ME, Fox GB, Schmidt M, Collins CA, Souers AJ, Iyengar R, Vasudevan A, Kym PR, Hancock AA, Rueter LE (July 2006). "Lack of efficacy of melanin-concentrating hormone-1 receptor antagonists in models of depression and anxiety". European Journal of Pharmacology. 540 (1–3): 115–20. doi:10.1016/j.ejphar.2006.04.043. PMID 16765941.
  4. ^ Jiang Y, Chen CA, Lu K, Daniewska I, De Leon J, Kong R, Forray C, Li B, Hegde LG, Wolinsky TD, Craig DA, Wetzel JM, Andersen K, Marzabadi MR (August 2007). "Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists Part 1. The discovery of arylacetamides as viable replacements for the dihydropyrimidinone moiety of an HTS hit". Journal of Medicinal Chemistry. 50 (16): 3870–82. doi:10.1021/jm060381c. PMID 17668921.
  5. ^ Chen CA, Jiang Y, Lu K, Daniewska I, Mazza CG, Negron L, Forray C, Parola T, Li B, Hegde LG, Wolinsky TD, Craig DA, Kong R, Wetzel JM, Andersen K, Marzabadi MR (August 2007). "Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits". Journal of Medicinal Chemistry. 50 (16): 3883–90. doi:10.1021/jm060383x. PMID 17668922.
  6. ^ Millan MJ, Gobert A, Panayi F, Rivet JM, Dekeyne A, Brocco M, Ortuno JC, Di Cara B (December 2008). "The melanin-concentrating hormone1 receptor antagonists, SNAP-7941 and GW3430, enhance social recognition and dialysate levels of acetylcholine in the frontal cortex of rats". The International Journal of Neuropsychopharmacology. 11 (8): 1105–22. doi:10.1017/S1461145708008894. PMID 18466669.
  7. ^ Hegde LG, Ping XL, Jochnowitz N, Craig DA (January 2009). "The role of melanin-concentrating hormone-1 receptors in the voiding reflex in rats". The Journal of Pharmacology and Experimental Therapeutics. 328 (1): 165–73. doi:10.1124/jpet.108.143495. PMID 18849359. S2CID 1883975.


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