VGF

VGF
독일 레이온 제조업체에 대해서는 Vereinigte Glanzstoff-Fabriken을 참조하십시오.
VGF
식별자
에일리어스VGF, SCG7, SgVii, VGF 신경증식인자 유도
외부 IDOMIM : 602186 MGI : 1343180 HomoloGene : 2536 GenCard : VGF
맞춤법
종.인간마우스
엔트레즈

7425

381677

앙상블

ENSG00000128564

ENSMUSG000037428

유니프로트

O15240

Q0VGU4

RefSeq(mRNA)

NM_003378

NM_001039385

RefSeq(단백질)

NP_003369

NP_001034474

장소(UCSC)Chr 7: 101.16 ~101.17 MbChr 5: 137.06 ~137.06 Mb
PubMed 검색[3][4]
위키데이터
인간 보기/편집마우스 표시/편집

유도성 VGF 또는 VGF 신경 성장 인자는 에너지 항상성, 대사[5] 및 시냅스 가소성을 [6]조절하는 역할을 할 수 있는 분비 단백질 및 신경펩타이드 전구체입니다.이 단백질은 1985년 리바이스 [7]등에 의해 PC12 세포에 대한 실험에서 처음 발견되었으며 이름은 비전자성 단백질이다.VGF 유전자 다른 질량의 기능하고 있어 다양한 폴리 펩티드, 그 중 공부를 최고로 단백질 가수 분해로 나뉘어 있는 전조가 있TLQP-21의 식욕과 inflammation,[8][9][10][11][12][13][14][15]과 TLQP-62뿐만 아니라 AQEE-30의 통제 속에 조정의 역할 depression-like behaviors[16][17][18][19][20] 부호화합니다.d제 추억입니다.[21][22]VGF 및 VGF 유래 펩타이드의 발현은 중추신경계 및 말초신경계의 뉴런 서브셋과 아데노하프시스, 부신수질, 위장관 및 [23]췌장의 내분비세포 특정 집단에서 검출된다.NGF, CREB 및 BDNF에 의해 VGF 발현을 유도하고 뉴로트로핀-3에 [24]의해 조절한다.물리적 운동은 생쥐 해마 조직에서 VGF 발현을 현저하게 증가시키고 항우울제의 [16][25][26][27]작용의 기초가 되는 것으로 생각되는 신경영양 시그널링 캐스케이드를 상향 조절한다.

병리학에서의 역할

개별 VGF 단편의 발현 변화는 다양한 신경학적 및 정신학적 조건에서 감지되었다.정신분열증에서, 한 연구는 VGF23-62[28] 펩타이드의 증가를 보여주었고, 후속 작은 연구는 약물이 단편의 가능한 개선 작용을 지적하며 발현을 더욱 증가시킨다는 것을 보여주었다.전두엽 치매에서[29] VGF26-62펩타이드 발현 저하가 발견되었으며, 근위축성 측삭경화증[30] 및 알츠하이머병에서 [31]아미노산 378-398을 포함한 단편 발현이 변화하고 있는 것으로 확인되었다.손상된 말초 신경에서도 VGF 발현이 나타나며 신경성 [32]통증에 관여하는 것으로 생각된다.교아종에서 VGF는 분화된 교아종 세포와 교아종 특이 암 줄기세포 사이의 피드백 루프에서 자가분비와 파라크린 역할을 하며 성장, 생존 및 자가 [33]갱신을 촉진하는 것으로 나타났다.

레퍼런스

  1. ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000128564 - 앙상블, 2017년 5월
  2. ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000037428 - 앙상블, 2017년 5월
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hahm S, Mizuno TM, Wu TJ, Wisor JP, Priest CA, Kozak CA, Boozer CN, Peng B, McEvoy RC, Good P, Kelley KA, Takahashi JS, Pintar JE, Roberts JL, Mobbs CV, Salton SR (July 1999). "Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance". Neuron. 23 (3): 537–48. doi:10.1016/S0896-6273(00)80806-5. PMID 10433265. S2CID 17096284.
  6. ^ Alder J, Thakker-Varia S, Bangasser DA, Kuroiwa M, Plummer MR, Shors TJ, Black IB (November 2003). "Brain-derived neurotrophic factor-induced gene expression reveals novel actions of VGF in hippocampal synaptic plasticity". The Journal of Neuroscience. 23 (34): 10800–8. doi:10.1523/JNEUROSCI.23-34-10800.2003. PMC 3374594. PMID 14645472.
  7. ^ Levi A, Eldridge JD, Paterson BM (July 1985). "Molecular cloning of a gene sequence regulated by nerve growth factor". Science. 229 (4711): 393–5. Bibcode:1985Sci...229..393L. doi:10.1126/science.3839317. PMID 3839317.
  8. ^ Bartolomucci A, La Corte G, Possenti R, Locatelli V, Rigamonti AE, Torsello A, Bresciani E, Bulgarelli I, Rizzi R, Pavone F, D'Amato FR, Severini C, Mignogna G, Giorgi A, Schininà ME, Elia G, Brancia C, Ferri GL, Conti R, Ciani B, Pascucci T, Dell'Omo G, Muller EE, Levi A, Moles A (September 2006). "TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity". Proceedings of the National Academy of Sciences of the United States of America. 103 (39): 14584–9. Bibcode:2006PNAS..10314584B. doi:10.1073/pnas.0606102103. PMC 1600003. PMID 16983076.
  9. ^ Rizzi R, Bartolomucci A, Moles A, D'Amato F, Sacerdote P, Levi A, La Corte G, Ciotti MT, Possenti R, Pavone F (August 2008). "The VGF-derived peptide TLQP-21: a new modulatory peptide for inflammatory pain". Neuroscience Letters. 441 (1): 129–33. doi:10.1016/j.neulet.2008.06.018. PMID 18586396. S2CID 207127085.
  10. ^ Bartolomucci A, Moles A, Levi A, Possenti R (September 2008). "Pathophysiological role of TLQP-21: gastrointestinal and metabolic functions". Eating and Weight Disorders. 13 (3): e49-54. PMID 19011364.
  11. ^ Zhao Z, Lange DJ, Ho L, Bonini S, Shao B, Salton SR, Thomas S, Pasinetti GM (April 2008). "Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis". International Journal of Medical Sciences. 5 (2): 92–9. doi:10.7150/ijms.5.92. PMC 2323610. PMID 18432310.
  12. ^ Bartolomucci A, Possenti R, Levi A, Pavone F, Moles A (November 2007). "The role of the vgf gene and VGF-derived peptides in nutrition and metabolism". Genes & Nutrition. 2 (2): 169–80. doi:10.1007/s12263-007-0047-0. PMC 2474945. PMID 18850173.
  13. ^ D'Amato F, Noli B, Brancia C, Cocco C, Flore G, Collu M, Nicolussi P, Ferri GL (May 2008). "Differential distribution of VGF-derived peptides in the adrenal medulla and evidence for their selective modulation". The Journal of Endocrinology. 197 (2): 359–69. doi:10.1677/JOE-07-0346. PMID 18434366.
  14. ^ Jethwa PH, Ebling FJ (2008). "Role of VGF-derived peptides in the control of food intake, body weight and reproduction". Neuroendocrinology. 88 (2): 80–7. doi:10.1159/000127319. PMID 18408361. S2CID 207626224.
  15. ^ Bartolomucci A, Bresciani E, Bulgarelli I, Rigamonti AE, Pascucci T, Levi A, Possenti R, Torsello A, Locatelli V, Muller EE, Moles A (March 2009). "Chronic intracerebroventricular injection of TLQP-21 prevents high fat diet induced weight gain in fast weight-gaining mice". Genes & Nutrition. 4 (1): 49–57. doi:10.1007/s12263-009-0110-0. PMC 2654049. PMID 19247701.
  16. ^ a b Hunsberger JG, Newton SS, Bennett AH, Duman CH, Russell DS, Salton SR, Duman RS (December 2007). "Antidepressant actions of the exercise-regulated gene VGF". Nature Medicine. 13 (12): 1476–82. doi:10.1038/nm1669. PMID 18059283. S2CID 17245049.
  17. ^ Thakker-Varia S, Krol JJ, Nettleton J, Bilimoria PM, Bangasser DA, Shors TJ, Black IB, Alder J (November 2007). "The neuropeptide VGF produces antidepressant-like behavioral effects and enhances proliferation in the hippocampus". The Journal of Neuroscience. 27 (45): 12156–67. doi:10.1523/jneurosci.1898-07.2007. PMC 3363962. PMID 17989282.
  18. ^ Thakker-Varia S, Alder J (February 2009). "Neuropeptides in depression: role of VGF". Behavioural Brain Research. 197 (2): 262–78. doi:10.1016/j.bbr.2008.10.006. PMC 2648305. PMID 18983874.
  19. ^ Jiang C, Lin WJ, Sadahiro M, Labonté B, Menard C, Pfau ML, Tamminga CA, Turecki G, Nestler EJ, Russo SJ, Salton SR (November 2017). "VGF function in depression and antidepressant efficacy". Molecular Psychiatry. 23 (7): 1632–1642. doi:10.1038/mp.2017.233. PMC 5962361. PMID 29158577.
  20. ^ Jiang, Cheng; Lin, Wei-Jye; Labonté, Benoit; Tamminga, Carol A.; Turecki, Gustavo; Nestler, Eric J.; Russo, Scott J.; Salton, Stephen R. (2018-11-20). "VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine". Neuropsychopharmacology. 44 (5): 971–981. doi:10.1038/s41386-018-0277-4. ISSN 1740-634X. PMC 6462025. PMID 30504797.
  21. ^ Bozdagi O, Rich E, Tronel S, Sadahiro M, Patterson K, Shapiro ML, Alberini CM, Huntley GW, Salton SR (September 2008). "The neurotrophin-inducible gene Vgf regulates hippocampal function and behavior through a brain-derived neurotrophic factor-dependent mechanism". The Journal of Neuroscience. 28 (39): 9857–69. doi:10.1523/jneurosci.3145-08.2008. PMC 2820295. PMID 18815270.
  22. ^ Lin WJ, Jiang C, Sadahiro M, Bozdagi O, Vulchanova L, Alberini CM, Salton SR (July 2015). "VGF and Its C-Terminal Peptide TLQP-62 Regulate Memory Formation in Hippocampus via a BDNF-TrkB-Dependent Mechanism". The Journal of Neuroscience. 35 (28): 10343–56. doi:10.1523/jneurosci.0584-15.2015. PMC 4502270. PMID 26180209.
  23. ^ Levi A, Ferri GL, Watson E, Possenti R, Salton SR (August 2004). "Processing, distribution, and function of VGF, a neuronal and endocrine peptide precursor". Cellular and Molecular Neurobiology. 24 (4): 517–33. doi:10.1023/B:CEMN.0000023627.79947.22. PMID 15233376. S2CID 36298228.
  24. ^ Mandolesi G, Gargano S, Pennuto M, Illi B, Molfetta R, Soucek L, Mosca L, Levi A, Jucker R, Nasi S (January 2002). "NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction". FEBS Letters. 510 (1–2): 50–6. doi:10.1016/S0014-5793(01)03227-6. PMID 11755530. S2CID 19320196.
  25. ^ Thakker-Varia S, Krol JJ, Nettleton J, Bilimoria PM, Bangasser DA, Shors TJ, Black IB, Alder J (November 2007). "The neuropeptide VGF produces antidepressant-like behavioral effects and enhances proliferation in the hippocampus". The Journal of Neuroscience. 27 (45): 12156–67. doi:10.1523/JNEUROSCI.1898-07.2007. PMC 3363962. PMID 17989282.
  26. ^ Malberg JE, Monteggia LM (May 2008). "VGF, a new player in antidepressant action?". Science Signaling. 1 (18): pe19. doi:10.1126/stke.118pe19. PMC 2745068. PMID 18460680.
  27. ^ Thakker-Varia S, Alder J (February 2009). "Neuropeptides in depression: role of VGF". Behavioural Brain Research. 197 (2): 262–78. doi:10.1016/j.bbr.2008.10.006. PMC 2648305. PMID 18983874.
  28. ^ Huang JT, Leweke FM, Oxley D, Wang L, Harris N, Koethe D, Gerth CW, Nolden BM, Gross S, Schreiber D, Reed B, Bahn S (November 2006). "Disease biomarkers in cerebrospinal fluid of patients with first-onset psychosis". PLOS Medicine. 3 (11): e428. doi:10.1371/journal.pmed.0030428. PMC 1630717. PMID 17090210.
  29. ^ Rüetschi U, Zetterberg H, Podust VN, Gottfries J, Li S, Hviid Simonsen A, McGuire J, Karlsson M, Rymo L, Davies H, Minthon L, Blennow K (December 2005). "Identification of CSF biomarkers for frontotemporal dementia using SELDI-TOF". Experimental Neurology. 196 (2): 273–81. doi:10.1016/j.expneurol.2005.08.002. PMID 16154129. S2CID 23401973.
  30. ^ Ranganathan S, Williams E, Ganchev P, Gopalakrishnan V, Lacomis D, Urbinelli L, Newhall K, Cudkowicz ME, Brown RH, Bowser R (December 2005). "Proteomic profiling of cerebrospinal fluid identifies biomarkers for amyotrophic lateral sclerosis". Journal of Neurochemistry. 95 (5): 1461–71. doi:10.1111/j.1471-4159.2005.03478.x. PMC 1540444. PMID 16313519.무료 전문
  31. ^ Carrette O, Demalte I, Scherl A, Yalkinoglu O, Corthals G, Burkhard P, Hochstrasser DF, Sanchez JC (August 2003). "A panel of cerebrospinal fluid potential biomarkers for the diagnosis of Alzheimer's disease". Proteomics. 3 (8): 1486–94. doi:10.1002/pmic.200300470. PMID 12923774. S2CID 25445068.
  32. ^ Moss A, Ingram R, Koch S, Theodorou A, Low L, Baccei M, Hathway GJ, Costigan M, Salton SR, Fitzgerald M (December 2008). "Origins, actions and dynamic expression patterns of the neuropeptide VGF in rat peripheral and central sensory neurones following peripheral nerve injury". Molecular Pain. 4: 1744-8069–4-62. doi:10.1186/1744-8069-4-62. PMC 2614976. PMID 19077191.
  33. ^ Wang X, Prager BC, Wu Q, Kim LJY, Gimple RC, Shi Y, et al. (April 2018). "Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression". Cell Stem Cell. 22 (4): 514–528.e5. doi:10.1016/j.stem.2018.03.011. PMC 5947947. PMID 29625067.