호모사피엔스의 단백질 코딩유전자
NPR2 식별자 별칭 NPR2 외부 ID OMIM : 108961 MGI : 97372 HomoloGene : 2970 GeneCard : NPR2 직교체 종 인간 마우스 엔트레스 앙상블 유니프로트 RefSeq(mRNA) RefSeq(단백질) 위치(UCSC) Cr 9: 35.79 – 35.81Mb Chr 4: 43.63 – 43.65Mb PubMed 검색[3] [4] 위키다타
NPR2 라고도 알려진 나트리우레틱 펩타이드 수용체 B/과닐레이트 사이클라아제 B(Atrionaterial 펩타이드 수용체 B) 는 심방 나트류 펩타이드 수용체 다.인간에서 그것은 NPR2 유전자 에 의해 암호화된다.[5]
NPR2 유전자의 돌연변이 는 팔다리가 짧은 불균형 왜소증 을 초래할 수 있다.[6]
참고 항목 참조 추가 읽기 Fox AA, Collard CD, Shernan SK, Seidman CE, Seidman JG, Liu KY, et al. (April 2009). "Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting" . Anesthesiology . 110 (4): 738–47. doi :10.1097/ALN.0b013e31819c7496 . PMC 2735337 PMID 19326473 . Potthast R, Abbey-Hosch SE, Antos LK, Marchant JS, Kuhn M, Potter LR (November 2004). "Calcium-dependent dephosphorylation mediates the hyperosmotic and lysophosphatidic acid-dependent inhibition of natriuretic peptide receptor-B/guanylyl cyclase-B" . The Journal of Biological Chemistry . 279 (47): 48513–9. doi :10.1074/jbc.M408247200 PMID 15371450 . Liew D, Schneider H, D'Agostino J, Shaw J, Krum H (March 2004). "Utility of B-type natriuretic peptide as a screen for left ventricular dysfunction in patients with diabetes: response to Epshteyn et al" . Diabetes Care . 27 (3): 848, author reply 848-9. doi :10.2337/diacare.27.3.848 PMID 14988324 . Antos LK, Abbey-Hosch SE, Flora DR, Potter LR (July 2005). "ATP-independent activation of natriuretic peptide receptors" . The Journal of Biological Chemistry . 280 (29): 26928–32. doi :10.1074/jbc.M505648200 PMID 15911610 . Poreba R, Poczatek K, Gać P, Poreba M, Gonerska M, Jonkisz A, et al. (April 2009). "SNP rs198389 (T-381 C) polymorphism in the B-type natriuretic peptide gene promoter in patients with atherosclerotic renovascular hypertension". Polskie Archiwum Medycyny Wewnetrznej . 119 (4): 219–24. PMID 19413180 . Koller KJ, Goeddel DV (October 1992). "Molecular biology of the natriuretic peptides and their receptors" . Circulation . 86 (4): 1081–8. doi :10.1161/01.cir.86.4.1081 PMID 1327579 . Fan D, Bryan PM, Antos LK, Potthast RJ, Potter LR (January 2005). "Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize". Molecular Pharmacology . 67 (1): 174–83. doi :10.1124/mol.104.002436 . PMID 15459247 . S2CID 53520 . Pagel-Langenickel I, Buttgereit J, Bader M, Langenickel TH (August 2007). "Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy" . Journal of Molecular Medicine . 85 (8): 797–810. doi :10.1007/s00109-007-0183-4 . PMID 17429599 . S2CID 42834676 . Rahmutula D, Cui J, Chen S, Gardner DG (September 2004). "Transcriptional regulation of type B human natriuretic Peptide receptor gene promoter: dependence on Sp1" . Hypertension . 44 (3): 283–8. doi :10.1161/01.HYP.0000136908.60317.92 PMID 15262909 . Hume AN, Buttgereit J, Al-Awadhi AM, Al-Suwaidi SS, John A, Bader M, et al. (January 2009). "Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux" . Human Molecular Genetics . 18 (2): 267–77. doi :10.1093/hmg/ddn354 . PMC 2638773 PMID 18945719 . Schulz S (June 2005). "C-type natriuretic peptide and guanylyl cyclase B receptor". Peptides . 26 (6): 1024–34. doi :10.1016/j.peptides.2004.08.027 . PMID 15911070 . S2CID 24299700 . Dickey DM, Yoder AR, Potter LR (July 2009). "A familial mutation renders atrial natriuretic Peptide resistant to proteolytic degradation" . The Journal of Biological Chemistry . 284 (29): 19196–202. doi :10.1074/jbc.M109.010777 . PMC 2740543 PMID 19458086 . Nozohoor S, Nilsson J, Lührs C, Roijer A, Algotsson L, Sjögren J (April 2009). "B-type natriuretic peptide as a predictor of postoperative heart failure after aortic valve replacement". Journal of Cardiothoracic and Vascular Anesthesia . 23 (2): 161–5. doi :10.1053/j.jvca.2008.11.006 . PMID 19167912 . Hachiya R, Ohashi Y, Kamei Y, Suganami T, Mochizuki H, Mitsui N, et al. (October 2007). "Intact kinase homology domain of natriuretic peptide receptor-B is essential for skeletal development" . The Journal of Clinical Endocrinology and Metabolism . 92 (10): 4009–14. doi :10.1210/jc.2007-1101 PMID 17652215 . Gratacòs M, Costas J, de Cid R, Bayés M, González JR, Baca-García E, et al. (September 2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment" . American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics . 150B (6): 808–16. doi :10.1002/ajmg.b.30902 PMID 19086053 . S2CID 44524739 . Bartels CF, Bükülmez H, Padayatti P, Rhee DK, van Ravenswaaij-Arts C, Pauli RM, et al. (July 2004). "Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux" . American Journal of Human Genetics . 75 (1): 27–34. doi :10.1086/422013 . PMC 1182004 PMID 15146390 . van den Akker F (August 2001). "Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors". Journal of Molecular Biology . 311 (5): 923–37. doi :10.1006/jmbi.2001.4922 . PMID 11556325 . 외부 링크 이 기사는 공공영역 에 있는 미국 국립 의학 도서관 의 텍스트를 통합하고 있다.
