LTBR 식별자 에일리어스 LTBR 외부 ID OMIM : 600979 MGI : 104875 HomoloGene : 1753 GenCard : LTBR 맞춤법 종. 인간 마우스 엔트레즈 앙상블 유니프로트 RefSeq(mRNA) RefSeq(단백질) 장소(UCSC) Chr 12: 6.38 ~6.39 Mb Chr 6: 125.28 ~125.29 Mb PubMed 검색[3] [4] 위키데이터
종양괴사인자수용체 슈퍼패밀리멤버3(TNFRSF3)라고도 알려진 림포톡신 베타수용체 (LTBR)는 아포토시스 및 사이토카인 [5] [6] [7] 림포톡신 의 세포표면수용체 이다.그것은 종양 괴사인자 수용체 슈퍼패밀리의 구성원이다.
기능. 이 유전자에 의해 암호화된 단백질은 종양괴사인자 (TNF) 수용체 계열의 구성원이다. 그것은 상피 및 골수 계통의 세포를 포함한 대부분의 세포 유형 표면에서 발현되지만, T 및 B 림프구 에서는 발현되지 않는다. 단백질은 림프톡신 막 형태(림프톡신-알파 및 림프톡신-베타의 복합체)와 특이적으로 결합한다. 암호화된 단백질과 그 배위자는 림프조직 과 변형된 세포의 발달과 구성에 역할을 한다. 부호화된 단백질의 활성화는 [5]
LTBR은 아포토시스 유발에 도움이 될 뿐만 아니라 사이토카인 인터류킨 8의 방출로 이어질 수 있다. HEK293 세포 에서 LTBR의 과잉발현은 IL-8 프로모터 활성을 증가시키고 IL-8 방출로 이어진다.LTBR은 또한 2차 림프 기관과 케모카인 [8]
구조. 라마찬드란 그림은 모든 잔류물의 64.6%가 선호하는 영역에 있음을 보여준다. 이 구조는 X-선 회절을 사용하여 발견되었다. 해상도는 3.50 앵스트롬입니다. 알파 및 베타 각도는 90도이고 감마 각도는 120도입니다.[9]
상호 작용 림포톡신 베타 수용체는 디아블로 호몰로그 [10] TRAF3 와 [11] [12] [13] 것 으로 나타났다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000111321 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000030339 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)" .^ Baens M, Chaffanet M, Cassiman JJ, van den Berghe H, Marynen P (April 1993). "Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid". Genomics . 16 (1): 214–8. doi :10.1006/geno.1993.1161 . PMID 8486360 . ^ Crowe PD, VanArsdale TL, Walter BN, Ware CF, Hession C, Ehrenfels B, Browning JL, Din WS, Goodwin RG, Smith CA (April 1994). "A lymphotoxin-beta-specific receptor". Science . 264 (5159): 707–10. Bibcode :1994Sci...264..707C . doi :10.1126/science.8171323 . PMID 8171323 . ^ Chang YH, Hsieh SL, Chen MC, Lin WW (August 2002). "Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation". Exp. Cell Res . 278 (2): 166–74. doi :10.1006/excr.2002.5573 . PMID 12169272 . ^ "MolProbity Ramachandran analysis" (PDF) . Archived from the original (PDF) on 2012-10-12.^ Kuai, Jun; Nickbarg Elliott; Wooters Joe; Qiu Yongchang; Wang Jack; Lin Lih-Ling (Apr 2003). "Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis" . J. Biol. Chem . United States. 278 (16): 14363–9. doi :10.1074/jbc.M208672200 ISSN 0021-9258 . PMID 12571250 . ^ VanArsdale, T L; VanArsdale S L; Force W R; Walter B N; Mosialos G; Kieff E ; Reed J C; Ware C F (Mar 1997). "Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB" . Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2460–5. Bibcode :1997PNAS...94.2460V . doi :10.1073/pnas.94.6.2460 ISSN 0027-8424 . PMC 20110 PMID 9122217 . ^ Wu, M Y; Wang P Y; Han S H; Hsieh S L (Apr 1999). "The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells" . J. Biol. Chem . UNITED STATES. 274 (17): 11868–73. doi :10.1074/jbc.274.17.11868 ISSN 0021-9258 . PMID 10207006 . ^ Marsters, S A; Ayres T M; Skubatch M; Gray C L; Rothe M; Ashkenazi A (May 1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1" . J. Biol. Chem . UNITED STATES. 272 (22): 14029–32. doi :10.1074/jbc.272.22.14029 ISSN 0021-9258 . PMID 9162022 .
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LTB(TNFβ) TNF(TNFα)
다른이들 TNF 슈퍼 패밀리 단백질 리간드: 4-1BL (CD137L, TNFSF9) 에이프릴 (CD256, TNFSF13) 배프(CD257, TNFSF13B) 캠 CD70(CD27L, TNFSF7) CD153 (CD30L, TNFSF8) CD154(CD40L, TNFSF5) 엑토디스플라신 (A , A2 )FasL (CD95L, TNFSF6) GITRL(TNFSF18) 라이트(HEVML, CD258, TNFSF14) OX40L(CD252, TNFSF4) LANKL (TRANCKL, OPGL, ODF, CD254, TNFSF11) Siva (CD27BP) TRAIL (CD253, TNFSF10) 트위크(TNFSF12) VEGI(TL1A, TNFSF15)
