호모사피엔스 종의 단백질 코딩 유전자
TRAIL 수용체 1 ( TRAILR1) 및 종양 괴사 인자 수용체 10A (TNFRSF10A )로도 알려진 죽음의 수용체 4 (DR4 )는 TNF 수용체 슈퍼패밀리의 세포 표면 수용체 로 TRAIL 을 결합하고 세포사멸 을 매개한다.[5] [6]
함수 이 유전자에 의해 암호화된 단백질은 TNF-수용체 슈퍼패밀리의 일원이다. 이 수용체는 종양 괴사 인자 관련 세포사멸 유도 리간드(TNFSF10/TRAIL)에 의해 활성화되어 세포사멸신호를 변환하여 세포사멸을 유도한다.[7]
FADD 결핍 마우스들을 대상으로 한 연구는 이 단백질에 의해 매개되는 세포사멸에 대해 어댑터 단백질을 포함하는 죽음의 영역인 FADD 가 필요하다고 제안했다.[8]
상호작용 TNFRSF10A는 DAP3 와 상호작용 하는 것으로 나타났다.[9]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000104689 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG00000022074 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Walczak H, Degli-Esposti MA, Johnson RS, Smolak PJ, Waugh JY, Boiani N, Timour MS, Gerhart MJ, Schooley KA, Smith CA, Goodwin RG, Rauch CT (Dec 1997). "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL" . EMBO J . 16 (17): 5386–97. doi :10.1093/emboj/16.17.5386 . PMC 1170170 PMID 9311998 . ^ Pan G, O'Rourke K, Chinnaiyan AM , Gentz R, Ebner R, Ni J, Dixit VM (April 1997). "The receptor for the cytotoxic ligand TRAIL". Science . 276 (5309): 111–3. doi :10.1126/science.276.5309.111 . PMID 9082980 . S2CID 19984057 . ^ "Entrez Gene: TNFRSF10A tumor necrosis factor receptor superfamily, member 10a" .^ Kuang AA, Diehl GE, Zhang J, Winoto A (2000). "FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts" . J. Biol. Chem . 275 (33): 25065–8. doi :10.1074/jbc.C000284200 PMID 10862756 . ^ Miyazaki, T; Reed J C (June 2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nat. Immunol . 2 (6): 493–500. doi :10.1038/88684 . ISSN 1529-2908 . PMID 11376335 . S2CID 6923467 . 추가 읽기 Kimberley FC, Screaton GR (2005). "Following a TRAIL: update on a ligand and its five receptors" . Cell Res . 14 (5): 359–72. doi :10.1038/sj.cr.7290236 PMID 15538968 . Fleury S, Thibodeau J, Croteau G, et al. (1995). "HLA-DR polymorphism affects the interaction with CD4" . J. Exp. Med . 182 (3): 733–41. doi :10.1084/jem.182.3.733 . PMC 2192178 PMID 7650480 . MacFarlane M, Ahmad M, Srinivasula SM, et al. (1997). "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL" . J. Biol. Chem . 272 (41): 25417–20. doi :10.1074/jbc.272.41.25417 PMID 9325248 . Schneider P, Bodmer JL, Thome M, et al. (1997). "Characterization of two receptors for TRAIL" (PDF) . FEBS Lett . 416 (3): 329–34. doi :10.1016/S0014-5793(97)01231-3 PMID 9373179 . S2CID 83145771 . Chaudhary PM, Eby M, Jasmin A, et al. (1998). "Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway" . Immunity . 7 (6): 821–30. doi :10.1016/S1074-7613(00)80400-8 PMID 9430227 . Schneider P, Thome M, Burns K, et al. (1998). "TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB" . Immunity . 7 (6): 831–6. doi :10.1016/S1074-7613(00)80401-X . PMID 9430228 . Diab BY, Lambert NC, L'Faqihi FE, et al. (1999). "Human collagen II peptide 256-271 preferentially binds to HLA-DR molecules associated with susceptibility to rheumatoid arthritis". Immunogenetics . 49 (1): 36–44. doi :10.1007/s002510050461 . PMID 9811967 . S2CID 22393348 . Costanzo A, Guiet C, Vito P (1999). "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB" . J. Biol. Chem . 274 (29): 20127–32. doi :10.1074/jbc.274.29.20127 PMID 10400625 . Hymowitz SG, Christinger HW, Fuh G, et al. (1999). "Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5" . Mol. Cell . 4 (4): 563–71. doi :10.1016/S1097-2765(00)80207-5 PMID 10549288 . Gibson SB, Oyer R, Spalding AC, et al. (2000). "Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAIL" . Mol. Cell. Biol . 20 (1): 205–12. doi :10.1128/MCB.20.1.205-212.2000 . PMC 85076 PMID 10594023 . Miyazaki T, Reed JC (2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nat. Immunol . 2 (6): 493–500. doi :10.1038/88684 . PMID 11376335 . S2CID 6923467 . Trauzold A, Wermann H, Arlt A, et al. (2001). "CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells" . Oncogene . 20 (31): 4258–69. doi :10.1038/sj.onc.1204559 PMID 11464292 . Dörr J, Bechmann I, Waiczies S, et al. (2002). "Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain" . J. Neurosci . 22 (4): RC209. doi :10.1523/JNEUROSCI.22-04-j0001.2002 PMC 6757573 PMID 11844843 . Koyama S, Koike N, Adachi S (2002). "Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor". J. Cancer Res. Clin. Oncol . 128 (2): 73–9. doi :10.1007/s004320100292 . PMID 11862476 . S2CID 19509629 . Guan B, Yue P, Lotan R, Sun SY (2002). "Evidence that the human death receptor 4 is regulated by activator protein 1" . Oncogene . 21 (20): 3121–9. doi :10.1038/sj.onc.1205430 PMID 12082627 . Söderström TS, Poukkula M, Holmström TH, et al. (2002). "Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8" . J. Immunol . 169 (6): 2851–60. doi :10.4049/jimmunol.169.6.2851 PMID 12218097 .
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케모킨 CSF
인터페론
IFNAR(α/β, I) 고민자: 알빈터페론 인터페론 알파(인터페론 알파, IFN-α) Interferon alfa (IFNA1 , IFNA2 , IFNA4 , IFNA5 , IFNA6 , IFNA7 , IFNA8 , IFNA10 , IFNA13 , IFNA14 , IFNA16 , IFNA17 , IFNA21 )인터페론 알파 2a 인터페론 알파 2b 인터페론 알파 n1 인터페론 알파콘-1 인터페론 알파-n3 인터페론 베타(IFN-β)( IFNB1 , IFNB3 )인터페론 베타 1a 인터페론 베타 1b 인터페론 카파(IFN-filename/changes/changes/changes, IFNK) 인터페론 오메가(IFN-Ω, IFNW1) 페긴터페론 알파-2a 페긴터페론 알파-2b IFNGR (1998, II) IFNLR (1998, III) 대신 여기 서 IL-28R(IFNLR)을 참조하십시오.
인터루킨 TGFβ TNF 다른이들
