IL36G

IL36G
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	4IZE, 4P0J, 4P0K, 4P0L
식별자
별칭	IL36G, 인터루킨 36, 감마, IL-1F9, IL-1H1, IL-1RP2, IL1E, IL1H1, IL1RP2, IL1F9, 인터루킨 36 감마
외부 ID	OMIM: 605542 MGI: 2449929 호몰로진: 49595 GeneCard: IL36G
유전자 위치(인간)
쳇.	염색체 2 (인간)
끝	112,985,658 bp
유전자 위치(마우스)
쳇.	염색체 2 (쥐)
끝	24,083,580bp
RNA 표현 패턴
	표현된 상단
	치주 섬유; ; 흉선; ; 편평한 상피; ; 잇몸; ; 피부 영역;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	사이토카인 활동; 인터루킨-1 수용체 결합;
셀룰러 컴포넌트	세포외 지역; 세포외 공간;
생물학적 과정	세포 세포 신호; 선천적인 면역 반응; 염증 반응; 면역 체계 과정; 면역 반응; 신호 수용체 활성 조절; 사이토카인 매개 신호 경로; 중성미자 화학 약품; 인터루킨-6 생산에 대한 긍정적인 규제; I-kappaB kinase/NF-kappaB 신호의 양성 조절; 근막 분화에 대한 부정적 규제; JNK 계단식 규제; 지용성당류에 대한 세포 반응; 근막 융해에 대한 부정적인 규제;
	출처:아미고 / 퀵고
직교체
	56300
	215257
	ENSG00000136688
	ENSMUSG00000044103
	Q9NZH8
	Q8R460; Q3U0P4
	NM_001278568; NM_019618
	NM_153511
	NP_001265497; NP_062564
	NP_705731
	위키다타
인간 보기/편집	마우스 보기/편집

이전에 인터루킨-1 가족 구성원으로 알려진 인터루킨-36 감마(Interleukin-36 gamma, IL1F9)는 인간에서 IL36G 유전자에 의해 인코딩되는 단백질이다.^[5]^[6]^[7]^[8]

함수

이 유전자에 의해 암호화된 단백질은 인터루킨-1 사이토카인 계열의 일원이다.이 유전자와 다른 8개의 인터루킨-1 가족 유전자는 2번 염색체에 사이토카인 유전자 군집을 형성한다.^[9]이 사이토카인의 활성은 인터루킨-1 수용체 유사2(IL1RL2/IL1R-rp2/IL-36 수용체)를 통해 매개되며 인터루킨-36 수용체 길항제(IL-36RA/IL1F5/IL-1 델타)에 의해 구체적으로 억제된다.인터페론-감마, 종양 괴사 인자-알파, 인터루킨-1 β(IL-1β)는 케라틴세포에서 이 사이토카인의 발현을 자극하는 것으로 보고되고 있다.케라틴세포에서 이 사이토카인의 표현은 다중 병원체 관련 분자 패턴(PAMP)에 의해서도 유도될 수 있다.^[10]IL-36γmRNA와 단백질 모두 건선 병변과 연계돼 습진과 건선을 구분하는 바이오마커로 활용돼 왔다.^[11]^[12]다른 많은 인터루킨-1 패밀리 사이토카인 IL-36γ은 완전한 생물학적 활동을 위해 N-terminus의 단백질 분리가 필요하다.^[13]그러나 IL-1β와 달리 IL-3636의 활성화는 인플라마솜에 독립적이다.IL-36γ은 특히 내생 단백질 분해효소 카테핀 S와 곰팡이 및 박테리아 병원균에서 추출한 외생 단백질 분해효소에 의해 분해된다.^[14]^[15]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000136688 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000044103 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Busfield SJ, Comrack CA, Yu G, Chickering TW, Smutko JS, Zhou H, Leiby KR, Holmgren LM, Gearing DP, Pan Y (June 2000). "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2". Genomics. 66 (2): 213–6. doi:10.1006/geno.2000.6184. PMID 10860666.
^ Kumar S, McDonnell PC, Lehr R, Tierney L, Tzimas MN, Griswold DE, Capper EA, Tal-Singer R, Wells GI, Doyle ML, Young PR (April 2000). "Identification and initial characterization of four novel members of the interleukin-1 family". The Journal of Biological Chemistry. 275 (14): 10308–14. doi:10.1074/jbc.275.14.10308. PMID 10744718.
^ Nicklin MJ, Barton JL, Nguyen M, FitzGerald MG, Duff GW, Kornman K (May 2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". Genomics. 79 (5): 718–25. doi:10.1006/geno.2002.6751. PMID 11991722.
^ Taylor SL, Renshaw BR, Garka KE, Smith DE, Sims JE (May 2002). "Genomic organization of the interleukin-1 locus". Genomics. 79 (5): 726–33. doi:10.1006/geno.2002.6752. PMID 11991723.
^ Garlanda C, Dinarello CA, Mantovani A (December 2013). "The interleukin-1 family: back to the future". Immunity. 39 (6): 1003–18. doi:10.1016/j.immuni.2013.11.010. PMC 3933951. PMID 24332029.
^ Gabay C, Towne JE (April 2015). "Regulation and function of interleukin-36 cytokines in homeostasis and pathological conditions". Journal of Leukocyte Biology. 97 (4): 645–52. doi:10.1189/jlb.3RI1014-495R. PMID 25673295. S2CID 36594830.
^ Berekméri A, Latzko A, Alase A, Macleod T, Ainscough JS, Laws P, et al. (September 2018). "Detection of IL-36γ through noninvasive tape stripping reliably discriminates psoriasis from atopic eczema" (PDF). The Journal of Allergy and Clinical Immunology. 142 (3): 988–991.e4. doi:10.1016/j.jaci.2018.04.031. hdl:2164/10849. PMC 6127028. PMID 29782895.
^ D'Erme AM, Wilsmann-Theis D, Wagenpfeil J, Hölzel M, Ferring-Schmitt S, Sternberg S, et al. (April 2015). "IL-36γ (IL-1F9) is a biomarker for psoriasis skin lesions". The Journal of Investigative Dermatology. 135 (4): 1025–1032. doi:10.1038/jid.2014.532. PMID 25525775.
^ Towne JE, Renshaw BR, Douangpanya J, Lipsky BP, Shen M, Gabel CA, Sims JE (December 2011). "Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity". The Journal of Biological Chemistry. 286 (49): 42594–602. doi:10.1074/jbc.M111.267922. PMC 3234937. PMID 21965679.
^ Ainscough JS, Macleod T, McGonagle D, Brakefield R, Baron JM, Alase A, et al. (March 2017). "Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36γ". Proceedings of the National Academy of Sciences of the United States of America. 114 (13): E2748–E2757. doi:10.1073/pnas.1620954114. PMC 5380102. PMID 28289191.
^ Macleod T, Ainscough JS, Hesse C, Konzok S, Braun A, Buhl AL, et al. (December 2020). "The Proinflammatory Cytokine IL-36γ Is a Global Discriminator of Harmless Microbes and Invasive Pathogens within Epithelial Tissues". Cell Reports. 33 (11): 108515. doi:10.1016/j.celrep.2020.108515. PMC 7758160. PMID 33326792.

추가 읽기

Nicklin MJ, Weith A, Duff GW (January 1994). "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes". Genomics. 19 (2): 382–4. doi:10.1006/geno.1994.1076. PMID 8188271.
Nothwang HG, Strahm B, Denich D, Kübler M, Schwabe J, Gingrich JC, Jauch A, Cox A, Nicklin MJ, Kurnit DM, Hildebrandt F (May 1997). "Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13". Genomics. 41 (3): 370–8. doi:10.1006/geno.1997.4654. PMID 9169134.
Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE (October 1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene". Biochemical and Biophysical Research Communications. 263 (3): 702–6. doi:10.1006/bbrc.1999.1440. PMID 10512743.
Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (January 2000). "Four new members expand the interleukin-1 superfamily". The Journal of Biological Chemistry. 275 (2): 1169–75. doi:10.1074/jbc.275.2.1169. PMID 10625660.
Barton JL, Herbst R, Bosisio D, Higgins L, Nicklin MJ (November 2000). "A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities". European Journal of Immunology. 30 (11): 3299–308. doi:10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S. PMID 11093146.
Pan G, Risser P, Mao W, Baldwin DT, Zhong AW, Filvaroff E, Yansura D, Lewis L, Eigenbrot C, Henzel WJ, Vandlen R (January 2001). "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp". Cytokine. 13 (1): 1–7. doi:10.1006/cyto.2000.0799. PMID 11145836.
Lin H, Ho AS, Haley-Vicente D, Zhang J, Bernal-Fussell J, Pace AM, Hansen D, Schweighofer K, Mize NK, Ford JE (June 2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member". The Journal of Biological Chemistry. 276 (23): 20597–602. doi:10.1074/jbc.M010095200. PMID 11278614.
Debets R, Timans JC, Homey B, Zurawski S, Sana TR, Lo S, Wagner J, Edwards G, Clifford T, Menon S, Bazan JF, Kastelein RA (August 2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2". Journal of Immunology. 167 (3): 1440–6. doi:10.4049/jimmunol.167.3.1440. PMID 11466363.
Sims JE, Nicklin MJ, Bazan JF, Barton JL, Busfield SJ, Ford JE, Kastelein RA, Kumar S, Lin H, Mulero JJ, Pan J, Pan Y, Smith DE, Young PR (October 2001). "A new nomenclature for IL-1-family genes". Trends in Immunology. 22 (10): 536–7. doi:10.1016/S1471-4906(01)02040-3. PMID 11574262.
Towne JE, Garka KE, Renshaw BR, Virca GD, Sims JE (April 2004). "Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs". The Journal of Biological Chemistry. 279 (14): 13677–88. doi:10.1074/jbc.M400117200. PMID 14734551.
Dennis RA, Trappe TA, Simpson P, Carroll C, Huang BE, Nagarajan R, Bearden E, Gurley C, Duff GW, Evans WJ, Kornman K, Peterson CA (November 2004). "Interleukin-1 polymorphisms are associated with the inflammatory response in human muscle to acute resistance exercise". The Journal of Physiology. 560 (Pt 3): 617–26. doi:10.1113/jphysiol.2004.067876. PMC 1665272. PMID 15331687.
Vos JB, van Sterkenburg MA, Rabe KF, Schalkwijk J, Hiemstra PS, Datson NA (May 2005). "Transcriptional response of bronchial epithelial cells to Pseudomonas aeruginosa: identification of early mediators of host defense". Physiological Genomics. 21 (3): 324–36. doi:10.1152/physiolgenomics.00289.2004. PMID 15701729.

인간 염색체 2의 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000136688 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000044103 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10860666-5] Busfield SJ, Comrack CA, Yu G, Chickering TW, Smutko JS, Zhou H, Leiby KR, Holmgren LM, Gearing DP, Pan Y (June 2000). "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2". Genomics. 66 (2): 213–6. doi:10.1006/geno.2000.6184. PMID 10860666.

[pmid10744718-6] Kumar S, McDonnell PC, Lehr R, Tierney L, Tzimas MN, Griswold DE, Capper EA, Tal-Singer R, Wells GI, Doyle ML, Young PR (April 2000). "Identification and initial characterization of four novel members of the interleukin-1 family". The Journal of Biological Chemistry. 275 (14): 10308–14. doi:10.1074/jbc.275.14.10308. PMID 10744718.

[pmid11991722-7] Nicklin MJ, Barton JL, Nguyen M, FitzGerald MG, Duff GW, Kornman K (May 2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". Genomics. 79 (5): 718–25. doi:10.1006/geno.2002.6751. PMID 11991722.

[pmid11991723-8] Taylor SL, Renshaw BR, Garka KE, Smith DE, Sims JE (May 2002). "Genomic organization of the interleukin-1 locus". Genomics. 79 (5): 726–33. doi:10.1006/geno.2002.6752. PMID 11991723.

[9] Garlanda C, Dinarello CA, Mantovani A (December 2013). "The interleukin-1 family: back to the future". Immunity. 39 (6): 1003–18. doi:10.1016/j.immuni.2013.11.010. PMC 3933951. PMID 24332029.

[10] Gabay C, Towne JE (April 2015). "Regulation and function of interleukin-36 cytokines in homeostasis and pathological conditions". Journal of Leukocyte Biology. 97 (4): 645–52. doi:10.1189/jlb.3RI1014-495R. PMID 25673295. S2CID 36594830.

[11] Berekméri A, Latzko A, Alase A, Macleod T, Ainscough JS, Laws P, et al. (September 2018). "Detection of IL-36γ through noninvasive tape stripping reliably discriminates psoriasis from atopic eczema" (PDF). The Journal of Allergy and Clinical Immunology. 142 (3): 988–991.e4. doi:10.1016/j.jaci.2018.04.031. hdl:2164/10849. PMC 6127028. PMID 29782895.

[12] D'Erme AM, Wilsmann-Theis D, Wagenpfeil J, Hölzel M, Ferring-Schmitt S, Sternberg S, et al. (April 2015). "IL-36γ (IL-1F9) is a biomarker for psoriasis skin lesions". The Journal of Investigative Dermatology. 135 (4): 1025–1032. doi:10.1038/jid.2014.532. PMID 25525775.

[13] Towne JE, Renshaw BR, Douangpanya J, Lipsky BP, Shen M, Gabel CA, Sims JE (December 2011). "Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity". The Journal of Biological Chemistry. 286 (49): 42594–602. doi:10.1074/jbc.M111.267922. PMC 3234937. PMID 21965679.

[14] Ainscough JS, Macleod T, McGonagle D, Brakefield R, Baron JM, Alase A, et al. (March 2017). "Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36γ". Proceedings of the National Academy of Sciences of the United States of America. 114 (13): E2748–E2757. doi:10.1073/pnas.1620954114. PMC 5380102. PMID 28289191.

[15] Macleod T, Ainscough JS, Hesse C, Konzok S, Braun A, Buhl AL, et al. (December 2020). "The Proinflammatory Cytokine IL-36γ Is a Global Discriminator of Harmless Microbes and Invasive Pathogens within Epithelial Tissues". Cell Reports. 33 (11): 108515. doi:10.1016/j.celrep.2020.108515. PMC 7758160. PMID 33326792.

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IL36G

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