인터루킨-17 수용체 B 는 인간에서 IL17RB 유전자 에 의해 암호화된 단백질 이다.[5] [6] [7]
이 유전자가 인코딩한 단백질은 사이토카인 수용체 다. 이 수용체는 구체적으로 IL17B 와 IL17E(IL25 )에 결합되지만, IL17(A) 나 IL17C 에는 결합하지 않는다. 이 수용체는 IL17E가 유도한 NF-κB 의 활성화와 IL8 의 생산을 중재하는 것으로 나타났다. 이 유전자의 상대 쥐의 발현이 장내 염증 시 유의하게 상향 조절되는 것으로 밝혀져 이 수용체의 면역억제 활성을 시사했다.[7]
참고 항목 참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG000056736 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000015966 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber MC, Wang W, Wathen K, Hodge V, Fisher CL, Olsen H, Ruben SM, Knyazev I, Cho YH, Kao V, Wilkinson KA, Carrell JA, Ebner R (Aug 2000). "A novel cytokine receptor-ligand pair. Identification, molecular Aaron 9 ok ò charkacterization, and in vivo immunomodulatory activity" . J Biol Chem . 275 (25): 19167–76. doi :10.1074/jbc.M910228199 PMID 10749887 . ^ Tian E, Sawyer JR, Largaespada DA, Jenkins NA, Copeland NG, Shaughnessy JD Jr (Jun 2000). "Evi27 encodes a novel membrane protein with homology to the IL17 receptor" . Oncogene . 19 (17): 2098–109. doi :10.1038/sj.onc.1203577 PMID 10815801 . ^ a b "Entrez Gene: IL17RB interleukin 17 receptor B" .
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