호모 사피엔스 종의 단백질 코드 유전자
TRAILR4 수용체 및 종양괴사인자 수용체 슈퍼패밀리 멤버 10D (TNFRSF10D )로도 알려진 디코이 수용체 2(DCR2 )는 TNF 수용체 슈퍼패밀리의 [3] [4] [5] 세포 표면 수용체이다.
기능. 이 유전자에 의해 암호화된 단백질은 TNF 수용체 슈퍼패밀리의 구성원이다. 이 수용체는 세포 외 TRAIL 결합 도메인, 막 통과 도메인 및 잘린 세포질 사망 도메인을 포함한다.
이 수용체는 아포토시스 를 유도하지 않으며 TRAIL 유도 세포 아포토시스에서 [5]
레퍼런스 추가 정보 Kimberley FC, Screaton GR (2005). "Following a TRAIL: update on a ligand and its five receptors" . Cell Res . 14 (5): 359–72. doi :10.1038/sj.cr.7290236 PMID 15538968 . Degli-Esposti MA, Dougall WC, Smolak PJ, et al. (1998). "The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain" . Immunity . 7 (6): 813–20. doi :10.1016/S1074-7613(00)80399-4 PMID 9430226 . Phillips TA, Ni J, Pan G, et al. (1999). "TRAIL (Apo-2L) and TRAIL receptors in human placentas: implications for immune privilege". J. Immunol . 162 (10): 6053–9. PMID 10229846 . Zhang XD, Franco AV, Nguyen T, et al. (2000). "Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells" . J. Immunol . 164 (8): 3961–70. doi :10.4049/jimmunol.164.8.3961 PMID 10754286 . Daigle I, Simon HU (2001). "Alternative functions for TRAIL receptors in eosinophils and neutrophils". Swiss Medical Weekly . 131 (17–18): 231–7. PMID 11420819 . Dörr J, Bechmann I, Waiczies S, et al. (2002). "Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain" . J. Neurosci . 22 (4): RC209. doi :10.1523/JNEUROSCI.22-04-j0001.2002 PMC 6757573 PMID 11844843 . Sun SY, Yue P, Chen X, et al. (2002). "The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells". Cancer Res . 62 (8): 2430–6. PMID 11956107 . Matysiak M, Jurewicz A, Jaskolski D, Selmaj K (2002). "TRAIL induces death of human oligodendrocytes isolated from adult brain" . Brain . 125 (Pt 11): 2469–80. doi :10.1093/brain/awf254 PMID 12390973 . Robertson NM, Zangrilli JG, Steplewski A, et al. (2003). "Differential expression of TRAIL and TRAIL receptors in allergic asthmatics following segmental antigen challenge: evidence for a role of TRAIL in eosinophil survival" . J. Immunol . 169 (10): 5986–96. doi :10.4049/jimmunol.169.10.5986 PMID 12421985 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ou D, Metzger DL, Wang X, et al. (2003). "TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction" . Diabetologia . 45 (12): 1678–88. doi :10.1007/s00125-002-0926-2 PMID 12488957 . Hasel C, Dürr S, Rau B, et al. (2003). "In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas" . Lab. Invest . 83 (6): 825–36. doi :10.1097/01.lab.0000073126.56932.46 PMID 12808117 . Kotelkin A, Prikhod'ko EA, Cohen JI, et al. (2003). "Respiratory syncytial virus infection sensitizes cells to apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand" . J. Virol . 77 (17): 9156–72. doi :10.1128/JVI.77.17.9156-9172.2003 . PMC 187410 PMID 12915532 . Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Res . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 PMID 12975309 . Shivapurkar N, Toyooka S, Toyooka KO, et al. (2004). "Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types" . Int. J. Cancer . 109 (5): 786–92. doi :10.1002/ijc.20041 PMID 14999791 . S2CID 10876221 . Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites" . Protein Sci . 13 (10): 2819–24. doi :10.1110/ps.04682504 . PMC 2286551 PMID 15340161 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . 이 기사에는 미국 국립 의학 도서관 (미국 국립 의학 도서관 )의 공공 도메인 텍스트가 포함되어 있습니다.
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케모카인 CSF
간섭체
IFNAR (α/β, I) 어거니스트: 알비테론 인터페론 알파(인터페론 알파, IFN-α) Interferon alfa (IFNA1 , IFNA2 , IFNA4 , IFNA5 , IFNA6 , IFNA7 , IFNA8 , IFNA10 , IFNA13 , IFNA14 , IFNA16 , IFNA17 , IFNA21 )인터페론 알파 2a 인터페론 알파 2b 인터페론 알파 n1 인터페론 알파콘 간섭 알파-n3 간섭 베타(IFN-β)( IFNB1 , IFNB3 )간섭 베타 1a 간섭 베타 1b Interferon kappa(IFN-'/'/'/'/'/', IFNK') 간섭 오메가(IFN-γ, IFNW1) 페긴터페론 알파-2a 페긴터페론 알파-2b IFNGR(,, II) IFNLR(,, III) 여기서 IL-28R(IFNLR)을 참조해 주세요.
인터류킨 TGFβ TNF 다른이들
