IFNB1
IFNB1
인터페론 베타(Interferon beta)는 IFNB1 유전자에 의해 인코딩되는 단백질이다.[5]자연 단백질과 재조합 단백질 형태는 항바이러스, 항균, 항암 특성을 가지고 있다.
Interferon 베타 1a(기존:Avonex 및 Revif) 및 Interferon 베타 1b(기존 이름:베타세론/베타페론)은 약으로 쓰인다.
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000171855 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000048806 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: IFNB1 interferon, beta 1, fibroblast".
추가 읽기
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- Francois DT, Katona IM, June CH, et al. (1988). "Examination of the inhibitory and stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens". Clin. Immunol. Immunopathol. 48 (3): 297–306. doi:10.1016/0090-1229(88)90023-2. PMID 3135963.
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- Blank KJ, McKernan LN, Murasko DM (1985). "Poly I:C or IFN-alpha/beta treatment inhibits macrophage induced T cell proliferation". J. Interferon Res. 5 (1): 215–21. doi:10.1089/jir.1985.5.215. PMID 3872918.
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- Taniguchi T, Ohno S, Fujii-Kuriyama Y, Muramatsu M (1980). "The nucleotide sequence of human fibroblast interferon cDNA". Gene. 10 (1): 11–5. doi:10.1016/0378-1119(80)90138-9. PMID 6157601.
- Houghton M, Easton MA, Stewart AG, et al. (1981). "The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase". Nucleic Acids Res. 8 (13): 2885–94. doi:10.1093/nar/8.13.2885. PMC 324132. PMID 6159580.
- Goeddel DV, Shepard HM, Yelverton E, et al. (1981). "Synthesis of human fibroblast interferon by E. coli". Nucleic Acids Res. 8 (18): 4057–74. doi:10.1093/nar/8.18.4057. PMC 324219. PMID 6159584.
- Houghton M, Stewart AG, Doel SM, et al. (1981). "The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers". Nucleic Acids Res. 8 (9): 1913–31. doi:10.1093/nar/8.9.1913. PMC 324047. PMID 6159597.
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- Lawn RM, Adelman J, Franke AE, et al. (1981). "Human fibroblast interferon gene lacks introns". Nucleic Acids Res. 9 (5): 1045–52. doi:10.1093/nar/9.5.1045. PMC 326735. PMID 6164984.
- Shepard HM, Leung D, Stebbing N, Goeddel DV (1982). "A single amino acid change in IFN-beta1 abolishes its antiviral activity". Nature. 294 (5841): 563–5. doi:10.1038/294563a0. PMID 6171735. S2CID 4344841.
- Content J, De Wit L, Pierard D, et al. (1982). "Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta". Proc. Natl. Acad. Sci. U.S.A. 79 (9): 2768–72. Bibcode:1982PNAS...79.2768C. doi:10.1073/pnas.79.9.2768. PMC 346287. PMID 6178110.
- Fiers W, Remaut E, Devos R, et al. (1983). "The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells". Philos. Trans. R. Soc. Lond. B Biol. Sci. 299 (1094): 29–38. doi:10.1098/rstb.1982.0103. PMID 6183692.
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