에프린 타입-A 수용체 6 은 인간에서 EPHA6 유전자 에 의해 암호화된 단백질 이다.[5] [6]
EphA6는 유방 발암 에 중요한 역할을 할 수 있으며 특히 스테로이드 수용체 음성 발현과 HER‑2 과다압박을[7] 유방암 에 대한 새로운 예후 지표와 치료목표 역할을 할 수 있다.
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG000080224 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000055540 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (December 2002). "The protein kinase complement of the human genome". Science . 298 (5600): 1912–34. doi :10.1126/science.1075762 . PMID 12471243 . S2CID 26554314 . ^ "Entrez Gene: EPHA6 EPH receptor A6" .^ Zhou D, Ren K, Wang J, Ren H, Yang W, Wang W, et al. (April 2018). "Erythropoietin-producing hepatocellular A6 overexpression is a novel biomarker of poor prognosis in patients with breast cancer" . Oncology Letters . 15 (4): 5257–5263. doi :10.3892/ol.2018.7919 . PMC 5840743 PMID 29552165 . 추가 읽기 Wilkinson DG (2000). Eph receptors and ephrins: regulators of guidance and assembly . Int. Rev. Cytol . International Review of Cytology. Vol. 196. pp. 177–244. doi :10.1016/S0074-7696(00)96005-4 . ISBN 9780123646002 PMID 10730216 . Xu Q, Mellitzer G, Wilkinson DG (July 2000). "Roles of Eph receptors and ephrins in segmental patterning" . Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences . 355 (1399): 993–1002. doi :10.1098/rstb.2000.0635 . PMC 1692797 PMID 11128993 . Nakamoto T, Kain KH, Ginsberg MH (February 2004). "Neurobiology: New connections between integrins and axon guidance" . Current Biology . 14 (3): R121-3. doi :10.1016/j.cub.2004.01.020 PMID 14986683 . S2CID 2957639 . Yamaguchi Y, Pasquale EB (June 2004). "Eph receptors in the adult brain". Current Opinion in Neurobiology . 14 (3): 288–96. doi :10.1016/j.conb.2004.04.003 . PMID 15194108 . S2CID 26196696 . Murai KK, Pasquale EB (August 2004). "Eph receptors, ephrins, and synaptic function". The Neuroscientist . 10 (4): 304–14. doi :10.1177/1073858403262221 . PMID 15271258 . S2CID 23900846 . Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, et al. (July 1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis" . Neuron . 17 (1): 9–19. doi :10.1016/S0896-6273(00)80276-7 PMID 8755474 . S2CID 1075856 . Aasheim HC, Munthe E, Funderud S, Smeland EB, Beiske K, Logtenberg T (January 2000). "A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes". Blood . 95 (1): 221–30. doi :10.1182/blood.V95.1.221 . PMID 10607706 . Prevost N, Woulfe D, Tanaka T, Brass LF (July 2002). "Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred" . Proceedings of the National Academy of Sciences of the United States of America . 99 (14): 9219–24. doi :10.1073/pnas.142053899 PMC 123121 PMID 12084815 . Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Research . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 PMID 12975309 . Hafner C, Schmitz G, Meyer S, Bataille F, Hau P, Langmann T, et al. (March 2004). "Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers" . Clinical Chemistry . 50 (3): 490–9. doi :10.1373/clinchem.2003.026849 PMID 14726470 .
외부 링크
안지오포에틴 CNTF EGF(ErbB)
Fgf.
FGFR1 FGFR2 고민자: 어소페르민 FGF (1 , 2(BFGF), 3 , 4 , 5 , 6 , 7 (KGF ), 8 , 9 , 10(KGF2), 17 , 18 , 22 )팔리퍼민 리피퍼민 셀퍼카티닙 스피리페르민 트라페르민 FGFR3 FGFR4 정렬되지 않음
HGF(c-Met) 인터넷 거버넌스 포럼
LNGF (p75NTR ) PDGF RET(GFL)
SCF(c-Kit) TGFβ 트르크
트르카 TrkB 고민자: 3,7-DHF 3,7,8,2'-THF 4'-DMA-7,8-DHF 7,3'-DHF 7,8-DHF 7,8,2'-THF 7,8,3'-THF 아미트립티라인 BDNF BNN-20 디옥시게두닌 디프레닐 디오스메틴 DMAQ-B1 HIOC LM22A-4 N-아세틸세로토닌 NT-3 NT-4 노르웨고닌 (5,7,8-THF) R7 R13 TDP6 TrkC
VEGF 다른이들 추가 성장 요인: 아드레노메둘린 군집 자극 요인 (대신 여기 를 참조하십시오) 결합조직성장인자(CTGF) 에프린 (A1 , A2 , A3 , A4 , A5 , B1 , B2 , B3 )Erythropoietin (대신 여기 를 참조하십시오)포도당-6-인산 이소메라아제(GPI; PGI, PHI, AMF) 글리아 성숙 계수(GMF) 간종유래성장인자(HDGF) 인터루킨 /T-세포 성장 요인 (대신 여기 참조)백혈병 억제 인자(LIF) 대식세포 자극 단백질(MSP; HLP, HGFLP) 미드킨(NEGF2) 마이그레이션 자극 계수(MSF; PRG4) 온코모둘린 뇌하수체 아데닐레이트 사이클라아제 활성화 펩타이드(PACAP) 플레오트로핀 레날라아제 트롬보포에틴 (대신 여기 를 참조)Wnt 신호 단백질 추가 성장 계수 수용체 조절기: 세레브롤리신 (네로트로핀 혼합물)
