EPHA7
EPHA7
에프린 타입-A 수용체 7은 인간에서 EPHA7 유전자에 의해 암호화된 단백질이다.[5][6]
이 유전자는 단백질-티로신키나아제 계열의 에프린 수용체 하위군에 속한다.EPH 및 EPH 관련 수용체는 특히 신경계통의 발달 사건을 매개하는 데 관여되어 왔다.EPH 하위 계열의 수용체들은 전형적으로 단일 키나제 영역을 가지고 있으며, 체스가 풍부한 도메인과 2개의 섬유질 타입 III를 포함하는 세포외 영역을 가지고 있다.에프린 수용체는 세포외 영역 시퀀스의 유사성과 에프린-A와 에프린-B 리간드를 결합하는 친화력을 바탕으로 2개 그룹으로 나뉜다.[6]
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000135333 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG0000289 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ephnomenclaturecommittee (Sep 1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020. S2CID 26773768.
- ^ a b "Entrez Gene: EPHA7 EPH receptor A7".
추가 읽기
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- Hock B, Böhme B, Karn T, et al. (1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. Bibcode:1998PNAS...95.9779H. doi:10.1073/pnas.95.17.9779. PMC 21413. PMID 9707552.
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