SKF-77,434

SKF-77,434
SKF-77,434
SKF-77,434 Structure.svg
식별자
  • 3-allyl-1-162-162-1,2,4,5-162-bjazepine-3-benzazepine-7,8-diol
CAS 번호
펍켐 CID
켐스파이더
유니
체비
켐벨
CompTox 대시보드 (EPA)
화학 및 물리적 데이터
공식C19H21NO2
어금질량295.382 g·190−1
3D 모델(JSmol)
  • c3ccc3C2CN(CC=C)CCc(cc1O)c2cc1O
  • InChi=1S/C19H21NO2/c1-2-9-20-20-10-8-15-18-2(21)19(22)12-16(15)17(15)14-6-4-3-5-7-14/h2-7,11-12,17-22H,8-10,132,132
  • 키:QBUVZVXIRYFENV-UHFFFAOYSA-N
(iii)

SKF-77,434는 선택적 도파민D1 수용체 부분작용제 역할을 하는 약물로 각성제 및 식욕부진 효과가 있다.SKF-81,297, 6-Br-APB 등 효능이 높은 다른1 D 작용제와 달리 SKF-77,434는 동물 연구에서 자기 관리를 유지하지 않아 코카인 중독의 잠재적 치료제로 연구돼 왔다.[1][2][3][4][5][6][7]

참조

  1. ^ Grech DM, Spealman RD, Bergman J (May 1996). "Self-administration of D1 receptor agonists by squirrel monkeys". Psychopharmacology. 125 (2): 97–104. doi:10.1007/BF02249407. PMID 8783382.
  2. ^ Weed MR, Paul IA, Dwoskin LP, Moore SE, Woolverton WL (October 1997). "The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys". The Journal of Pharmacology and Experimental Therapeutics. 283 (1): 29–38. PMID 9336305.
  3. ^ Platt DM, Rowlett JK, Spealman RD (June 2000). "Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434". The Journal of Pharmacology and Experimental Therapeutics. 293 (3): 1017–26. PMID 10869406.
  4. ^ Platt DM, Rowlett JK, Spealman RD (September 2001). "Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys". Psychopharmacology. 157 (2): 208–16. doi:10.1007/s002130100779. PMID 11594448.
  5. ^ Mutschler NH, Bergman J (April 2002). "Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys". Psychopharmacology. 160 (4): 362–70. doi:10.1007/s00213-001-0976-z. PMID 11919663.
  6. ^ Desai RI, Terry P, Katz JL (August 2005). "A comparison of the locomotor stimulant effects of D1-like receptor agonists in mice". Pharmacology, Biochemistry, and Behavior. 81 (4): 843–8. doi:10.1016/j.pbb.2005.06.006. PMID 16000217.
  7. ^ Katz JL, Kopajtic TA, Terry P (June 2006). "Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats". Behavioural Pharmacology. 17 (4): 303–9. doi:10.1097/01.fbp.0000205015.67079.f7. PMID 16914948.
Stub icon

신경계통에 관한 이 약물 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.