N,N-디메틸페네틸아민

N,N-Dimethylphenethylamine
N,N-디메틸페네틸아민
N,N-Dimethylphenethylamine.svg
이름
선호 IUPAC 이름
N,N-디메틸-2-페닐탄-1-아민
기타 이름
N,N-디메틸-2-페닐타마닌
N,N-디메틸-β-페닐시아민
N,N-DMPEA
식별자
3D 모델(JSmol)
켐스파이더
ECHA InfoCard 100.156.869 Edit this at Wikidata
펍켐 CID
유니
  • InChi=1S/C10H15N/c1-11(2)9-8-10-6-4-3-7-10/h3-7H,8-9H2,1-2H3
    키: TXOFSCHERQ-UHFFFAOYSA-N
  • CN(C)CC1=CC=CC=C1
특성.
C10H15N
어금질량 149.237 g·1998−1
달리 명시된 경우를 제외하고, 표준 상태(25°C [77°F], 100 kPa)의 재료에 대한 데이터가 제공된다.
Infobox 참조 자료

N, N-Dimethylphenethylamine(N,N-DMPEA)은 향미제로 사용되는 대체 페네틸아민이다. 난초 에리아 자렌시스로부터 처음 격리된 알칼로이드다.[1] 그것의 향기는 "달콤하고, 비린내 나는"로 묘사된다. 주로 시리얼, 치즈, 유제품, 생선, 과일, 육류 등에 쓰인다.[2] 각성제 효과를 주장하는 사전 운동과 보디빌딩 보조제에도 활용되고 있다.[3]

N,N-DMPEA가 인간에게 TAAR1의 작용제 역할을 하며,[4] 쥐에게 5-HT1A 리간드로 작용한다는 증거도 있다. 일부 덜 결정적인 연구는 또한 그것이 억제제가 아닌 효소 기질로서 MAO-B와 상호작용을 가졌을 가능성이 높다는 것을 보여주었다.[5]

안전

N,N-DMPEA has been found to be safe for use as a flavoring agent by the Flavor and Extract Manufacturers Association (FEMA) Expert Panel[6] and also by the Joint Expert Committee on Food Additives (JECFA)[7]—a collaboration between the Food and Agricultural Organization of the United Nations (FAO) and the World Health Organization.[8]

참조

  1. ^ K. Hedman, K. Leander and B. Luning (1969). "Studies on Orchidaceae Alkaloids. XV. Phenethylamines from Eria jarensis Ames". Acta Chem. Scand. 23: 3261. doi:10.3891/acta.chem.scand.23-3261.
  2. ^ Burdock, G.A. (2016). Fenaroli's Handbook of Flavor Ingredients, Sixth Edition. CRC Press. p. 499. ISBN 9781420090864. Retrieved 2016-09-13.
  3. ^ "Eria Jarensis Extract / N-phenethyl dimethylamine: The Next Big Thing?". blog.priceplow.com. Retrieved 2016-10-05.
  4. ^ Wainscott DB, Little SP, Yin T, Tu Y, Rocco VP, He JX, Nelson DL (January 2007). "Pharmacologic characterization of the cloned human trace amine-associated receptor1 (TAAR1) and evidence for species differences with the rat TAAR1". The Journal of Pharmacology and Experimental Therapeutics. 320 (1): 475–485. doi:10.1124/jpet.106.112532. PMID 17038507. S2CID 10829497.
  5. ^ Pubchem. "N,N-Dimethylphenethylamine C10H15N - PubChem". pubchem.ncbi.nlm.nih.gov. Retrieved 2016-10-05.
  6. ^ "Flavor and Extract Manufacturers Association (FEMA) GRAS Flavoring Substances 22". www.femaflavor.org. Retrieved 2019-01-14.
  7. ^ "Evaluations of the Joint FAO/WHO Expert Committee on Food Additives (JECFA)". apps.who.int. Retrieved 2019-01-14.
  8. ^ "The Joint FAO/WHO Expert Committee on Food Additives (JECFA)". www.fao.org. Retrieved 2019-01-14. The Joint FAO/WHO Expert Committee on Food Additives (JECFA) is an international expert scientific committee that is administered jointly by the Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO).