G-130
G-130 | |
| 법적현황 | |
|---|---|
| 법적현황 |
|
| 식별자 | |
| |
| CAS 번호 | |
| 펍켐 CID | |
| 켐스파이더 | |
| 유니 | |
| CompTox 대시보드 (EPA) | |
| 화학 및 물리적 데이터 | |
| 공식 | C12H17NO |
| 어금질량 | 191.274 g·198−1 |
| 3D 모델(JSmol) | |
| |
| |
| (iii) | |
G-130(GP-130, 2-페닐-5,5-디메틸틸트라하이드로-1,4-옥사진)[1]은 각성제 및 식이성 효과가 있는 약물로, 페메트라진과 관련이 있다.[2][3][4]
구조 아날로그
모노아민 흡수 및 니코틴 아세틸콜린 수용체의 복합 억제제 역할을 하는 G-130과 라다팩신 관련 화합물이 합성됐다.[5]
참고 항목
참조
- ^ GB 1336732 - Diethanolamine 파생 모델.
- ^ Fanelli O (June 1973). "Pharmacological and toxicological study of a new psychotropic stimulant: the 2-phenyl-5-dimethyl-tetrahydro-1,4-oxazine, in comparison with d,l-amphetamine, phenmetrazine and pemoline-Mg". Arzneimittel-Forschung. 23 (6): 810–6. PMID 4740767.
- ^ Fanelli O, Mazzoncini V, Ferri S (October 1974). "Toxicological and teratological study of 2-phenyl-5,5-dimethyl-tetrahydro-1,4-oxazine hydrochloride (G 130), a psychostimulant drug". Arzneimittel-Forschung. 24 (10): 1627–32. PMID 4479774.
- ^ Fanelli O, Mazzoncini V, Trallori L (December 1974). "Antagonism of psychostimulant 2-phenyl-5,5-dimethyl-tetrahydro-1,4-oxazine hydrochloride (G 130) to central nervous system depressing drugs. Monoamine oxidase inhibitory activity and norepinephrine and serotonin induced changes. Comparison with dL-amphetamine". Arzneimittel-Forschung. 24 (12): 2025–9. PMID 4480283.
- ^ Carroll, F. I.; Muresan, A. Z.; Blough, B. E.; Navarro, H. N. A.; Mascarella, S. W.; Eaton, J. B.; Huang, X.; Damaj, M. I.; Lukas, R. J. (2011). "Synthesis of 2-(Substituted Phenyl)-3,5,5-trimethylmorpholine Analogues and Their Effects on Monoamine Uptake, Nicotinic Acetylcholine Receptor Function, and Behavioral Effects of Nicotine". Journal of Medicinal Chemistry. 54 (5): 1441–1448. doi:10.1021/jm1014555. PMC 3048909. PMID 21319801.
