ORG-26576
ORG-26576 | |
| 식별자 | |
|---|---|
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| CAS 번호 | |
| PubChem CID | |
| 켐스파이더 | |
| 유니 | |
| 화학 및 물리 데이터 | |
| 공식 | C11H12N2O2 |
| 몰 질량 | 204.229 g/120−1 |
| 3D 모델(JSmol) | |
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ORG-26576은 원래 Cortex Pharmacuticals가 개발한 앰파킨으로 Organon International에 개발 허가를 받았습니다.동물 연구에서 그것은 AMPA 수용체 기능을 효과적으로 증강시켜 BDNF 방출을 증가시키고 신경 분화와 생존을 강화하며 표준화된 [1][2][3][4][5][6]분석에서 이방성 효과를 발생시키는 것으로 나타났다.주요 우울증 장애에 대한 2단계 임상시험의 실패로 [7]항우울제로서의 개발이 중단되었다.
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레퍼런스
- ^ Jordan GR, McCulloch J, Shahid M, Hill DR, Henry B, Horsburgh K (August 2005). "Regionally selective and dose-dependent effects of the ampakines Org 26576 and Org 24448 on local cerebral glucose utilisation in the mouse as assessed by 14C-2-deoxyglucose autoradiography". Neuropharmacology. 49 (2): 254–64. doi:10.1016/j.neuropharm.2005.03.011. PMID 15993447.
- ^ Su XW, Li XY, Banasr M, Koo JW, Shahid M, Henry B, Duman RS (October 2009). "Chronic treatment with AMPA receptor potentiator Org 26576 increases neuronal cell proliferation and survival in adult rodent hippocampus". Psychopharmacology. 206 (2): 215–22. doi:10.1007/s00213-009-1598-0. PMID 19603152.
- ^ Hamlyn E, Brand L, Shahid M, Harvey BH (October 2009). "The ampakine, Org 26576, bolsters early spatial reference learning and retrieval in the Morris water maze: a subchronic, dose-ranging study in rats". Behavioural Pharmacology. 20 (7): 662–7. doi:10.1097/FBP.0b013e328331ba1b. PMID 19741506.
- ^ Bursi R, Erdemli G, Campbell R, Hutmacher MM, Kerbusch T, Spanswick D, et al. (December 2011). "Translational PK-PD modelling of molecular target modulation for the AMPA receptor positive allosteric modulator Org 26576". Psychopharmacology. 218 (4): 713–24. doi:10.1007/s00213-011-2365-6. PMID 21647578.
- ^ Jardemark K, Marcus MM, Malmerfelt A, Shahid M, Svensson TH (May 2012). "Differential effects of AMPA receptor potentiators and glycine reuptake inhibitors on antipsychotic efficacy and prefrontal glutamatergic transmission". Psychopharmacology. 221 (1): 115–31. doi:10.1007/s00213-011-2554-3. PMID 22068461.
- ^ Fumagalli F, Calabrese F, Luoni A, Shahid M, Racagni G, Riva MA (February 2012). "The AMPA receptor potentiator Org 26576 modulates stress-induced transcription of BDNF isoforms in rat hippocampus". Pharmacological Research. 65 (2): 176–81. doi:10.1016/j.phrs.2011.10.004. PMID 22079295.
- ^ Machado-Vieira R, Henter ID, Zarate CA (May 2017). "New targets for rapid antidepressant action". Progress in Neurobiology. 152: 21–37. doi:10.1016/j.pneurobio.2015.12.001. PMC 4919246. PMID 26724279.
