IRAK1

IRAK1
IRAK1
식별자.
별칭IRAK1, IRAK, 펠레, 인터루킨1 수용체 관련 키나아제 1
외부 IDOMIM: 300283 MGI: 107420 호몰로진: 37496 GeneCard: IRAK1
직교체
종인간마우스
엔트레스

3654

16179

앙상블

ENSG00000184216

ENSMUSG00000031392

유니프로트

P51617

Q62406

RefSeq(mRNA)

NM_001025242
NM_001025243
NM_001569

NM_001177973
NM_001177974
NM_001177975
NM_001177976
NM_008363

RefSeq(단백질)

NP_001020413
NP_001020414
NP_001560

NP_001171444
NP_001171445
NP_001171446
NP_001171447
NP_032389

위치(UCSC)Cr X: 154.01 – 154.02MbCr X: 74.01 – 74.02Mb
PubMed 검색[3][4]
위키다타
인간 보기/편집마우스 보기/편집

인터루킨-1 수용체 관련 키나아제 1은 인간에서 IRAK1 유전자에 의해 암호화된 효소다.[5][6]

함수

이 유전자는 인터루킨-1 수용체 관련 키나아제 1을 인코딩하는데, 자극시 인터루킨-1 수용체(IL1R)와 연관되는 두 가지 퍼팅 세린/트레오닌 키나제 중 하나이다. 이 유전자는 전사 계수 NF-카파 B의 IL1 유도 상향 조절에 부분적으로 책임이 있다. 대안으로 다른 ISO 양식을 인코딩하는 분할된 대본 변형이 이 유전자에 대해 발견되었다.[7]

유료 수용체 신호 경로. 점선 회색 선은 알 수 없는 연결을 나타냄

상호작용

IRAK1은 다음과 상호 작용하는 것으로 나타났다.

임상적 유의성

IRAK1 신호는 류머티스 관절염과 관련되어 있다.[27]

참조

  1. ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000184216 - 앙상블, 2017년 5월
  2. ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000031392 - 앙상블, 2017년 5월
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Muzio M, Ni J, Feng P, Dixit VM (November 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343): 1612–5. Bibcode:1997Sci...278.1612M. doi:10.1126/science.278.5343.1612. PMID 9374458.
  6. ^ Cao Z, Henzel WJ, Gao X (February 1996). "IRAK: a kinase associated with the interleukin-1 receptor". Science. 271 (5252): 1128–31. Bibcode:1996Sci...271.1128C. doi:10.1126/science.271.5252.1128. PMID 8599092. S2CID 42977425.
  7. ^ "Entrez Gene: IRAK1 interleukin-1 receptor-associated kinase 1".
  8. ^ a b c d Windheim M, Stafford M, Peggie M, Cohen P (March 2008). "Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase". Molecular and Cellular Biology. 28 (5): 1783–91. doi:10.1128/MCB.02380-06. PMC 2258775. PMID 18180283.
  9. ^ a b Vig E, Green M, Liu Y, Yu KY, Kwon HJ, Tian J, Goebl MG, Harrington MA (March 2001). "SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity". The Journal of Biological Chemistry. 276 (11): 7859–66. doi:10.1074/jbc.M010399200. PMID 11096118.
  10. ^ a b Conze DB, Wu CJ, Thomas JA, Landstrom A, Ashwell JD (May 2008). "Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation". Molecular and Cellular Biology. 28 (10): 3538–47. doi:10.1128/MCB.02098-07. PMC 2423148. PMID 18347055.
  11. ^ Chen BC, Wu WT, Ho FM, Lin WW (July 2002). "Inhibition of interleukin-1beta -induced NF-kappa B activation by calcium/calmodulin-dependent protein kinase kinase occurs through Akt activation associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of MyD88". The Journal of Biological Chemistry. 277 (27): 24169–79. doi:10.1074/jbc.M106014200. PMID 11976320.
  12. ^ a b Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (July 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.
  13. ^ a b Li S, Strelow A, Fontana EJ, Wesche H (April 2002). "IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase". Proceedings of the National Academy of Sciences of the United States of America. 99 (8): 5567–72. Bibcode:2002PNAS...99.5567L. doi:10.1073/pnas.082100399. PMC 122810. PMID 11960013.
  14. ^ Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (September 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature. 413 (6851): 78–83. Bibcode:2001Natur.413...78F. doi:10.1038/35092578. PMID 11544529. S2CID 4333764.
  15. ^ a b c Database, GeneCards Human Gene. "IRAK1 Gene - GeneCards IRAK1 Protein IRAK1 Antibody". www.genecards.org.
  16. ^ Muzio, M. (1997). "IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling". Science. 278 (5343): 1612–1615. Bibcode:1997Sci...278.1612M. doi:10.1126/science.278.5343.1612. ISSN 0036-8075. PMID 9374458.
  17. ^ Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X (November 2001). "IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B". The Journal of Biological Chemistry. 276 (45): 41661–7. doi:10.1074/jbc.M102262200. PMID 11518704.
  18. ^ Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV (October 1996). "TRAF6 is a signal transducer for interleukin-1". Nature. 383 (6599): 443–6. Bibcode:1996Natur.383..443C. doi:10.1038/383443a0. PMID 8837778. S2CID 4269027.
  19. ^ Takatsuna H, Kato H, Gohda J, Akiyama T, Moriya A, Okamoto Y, Yamagata Y, Otsuka M, Umezawa K, Semba K, Inoue J (April 2003). "Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling". The Journal of Biological Chemistry. 278 (14): 12144–50. doi:10.1074/jbc.M300720200. PMID 12566447.
  20. ^ Ling L, Goeddel DV (August 2000). "T6BP, a TRAF6-interacting protein involved in IL-1 signaling". Proceedings of the National Academy of Sciences of the United States of America. 97 (17): 9567–72. Bibcode:2000PNAS...97.9567L. doi:10.1073/pnas.170279097. PMC 16905. PMID 10920205.
  21. ^ Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K (April 2001). "Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway". Molecular and Cellular Biology. 21 (7): 2475–84. doi:10.1128/MCB.21.7.2475-2484.2001. PMC 86880. PMID 11259596.
  22. ^ Chen F, Du Y, Zhang Z, Chen G, Zhang M, Shu HB, Zhai Z, Chen D (April 2008). "Syntenin negatively regulates TRAF6-mediated IL-1R/TLR4 signaling". Cellular Signalling. 20 (4): 666–74. doi:10.1016/j.cellsig.2007.12.002. PMID 18234474.
  23. ^ Newton K, Matsumoto ML, Wertz IE, Kirkpatrick DS, Lill JR, Tan J, Dugger D, Gordon N, Sidhu SS, Fellouse FA, Komuves L, French DM, Ferrando RE, Lam C, Compaan D, Yu C, Bosanac I, Hymowitz SG, Kelley RF, Dixit VM (August 2008). "Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies". Cell. 134 (4): 668–78. doi:10.1016/j.cell.2008.07.039. PMID 18724939.
  24. ^ Xiao H, Qian W, Staschke K, Qian Y, Cui G, Deng L, Ehsani M, Wang X, Qian YW, Chen ZJ, Gilmour R, Jiang Z, Li X (May 2008). "Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation". The Journal of Biological Chemistry. 283 (21): 14654–64. doi:10.1074/jbc.M706931200. PMC 2386918. PMID 18326498.
  25. ^ Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nature Cell Biology. 2 (6): 346–51. doi:10.1038/35014038. PMID 10854325. S2CID 32036101.
  26. ^ He X, Jing Z, Cheng G (2014). "MicroRNAs: new regulators of Toll-like receptor signalling pathways". BioMed Research International. 2014: 1–14. doi:10.1155/2014/945169. PMC 3977468. PMID 24772440.
  27. ^ Reference, Genetics Home. "IRAK1 gene". Genetics Home Reference.

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