호모사피엔스 종의 단백질 코딩 유전자
PLK3 라고도 알려진 폴로 유사키나아제3(Drosopila )는 인간에게 PLK3 유전자 에 의해 암호화된 효소 다.[5] [6]
함수 시토카인 유도키나아제는 퍼팅 세린/스레오닌 키나아제다. CNK는 촉매 영역과 putative 규제 영역을 모두 포함한다. 그것은 세포주기 진행과 종양기간 의 조절에 역할을 할 수 있다.[5]
상호작용 PLK3는 다음과 상호 작용하는 것으로 나타났다.
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000173846 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000028680 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: PLK3 polo-like kinase 3 (Drosophila)" .^ Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W (August 1996). "Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas" . J. Biol. Chem . 271 (32): 19402–8. doi :10.1074/jbc.271.32.19402 PMID 8702627 . ^ Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (Oct 1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk" . Oncogene . 18 (44): 6029–36. doi :10.1038/sj.onc.1202983 PMID 10557092 . ^ a b Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ (Sep 2002). "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways" . Oncogene . 21 (43): 6633–40. doi :10.1038/sj.onc.1205850 PMID 12242661 . ^ Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W (Nov 2001). "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway" . J. Biol. Chem . 276 (46): 43305–12. doi :10.1074/jbc.M106050200 PMID 11551930 . 추가 읽기 Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W (1996). "Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas" . J. Biol. Chem . 271 (32): 19402–8. doi :10.1074/jbc.271.32.19402 PMID 8702627 . 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"The physical association and phosphorylation of Cdc25C protein phosphatase by Prk" . Oncogene . 18 (44): 6029–36. doi :10.1038/sj.onc.1202983 PMID 10557092 . Shieh SY, Ahn J, Tamai K, Taya Y, Prives C (2000). "The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites" . Genes Dev . 14 (3): 289–300. PMC 316358 PMID 10673501 . Dai W, Li Y, Ouyang B, Pan H, Reissmann P, Li J, Wiest J, Stambrook P, Gluckman JL, Noffsinger A, Bejarano P (2000). "PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer". Genes Chromosomes Cancer . 27 (3): 332–6. doi :10.1002/(SICI)1098-2264(200003)27:3<332::AID-GCC15>3.0.CO;2-K . PMID 10679924 . Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ (2000). "Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro" . Proc. Natl. Acad. Sci. U.S.A . 97 (19): 10389–94. Bibcode :2000PNAS...9710389M . doi :10.1073/pnas.190030497 PMC 27034 PMID 10973490 . Holtrich U, Wolf G, Yuan J, Bereiter-Hahn J, Karn T, Weiler M, Kauselmann G, Rehli M, Andreesen R, Kaufmann M, Kuhl D, Strebhardt K (2000). "Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages" . Oncogene . 19 (42): 4832–9. doi :10.1038/sj.onc.1203845 PMID 11039900 . Bulavin DV, Higashimoto Y, Popoff IJ, Gaarde WA, Basrur V, Potapova O, Appella E, Fornace AJ (2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature . 411 (6833): 102–7. Bibcode :2001Natur.411..102B . doi :10.1038/35075107 . PMID 11333986 . S2CID 4410763 . Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W (2001). "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway" . J. Biol. Chem . 276 (46): 43305–12. doi :10.1074/jbc.M106050200 PMID 11551930 . Latonen L, Taya Y, Laiho M (2001). "UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts" . Oncogene . 20 (46): 6784–93. doi :10.1038/sj.onc.1204883 PMID 11709713 . Ahn JY, Li X, Davis HL, Canman CE (2002). "Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain" . J. Biol. Chem . 277 (22): 19389–95. doi :10.1074/jbc.M200822200 PMID 11901158 . Sumara I, Vorlaufer E, Stukenberg PT, Kelm O, Redemann N, Nigg EA, Peters JM (2002). "The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase" . Mol. Cell . 9 (3): 515–25. doi :10.1016/S1097-2765(02)00473-2 PMID 11931760 . Wang Q, Xie S, Chen J, Fukasawa K, Naik U, Traganos F, Darzynkiewicz Z, Jhanwar-Uniyal M, Dai W (2002). "Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity" . Mol. Cell. 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