호모사피엔스 종의 단백질 코딩 유전자
ACVR1C 또는 AK-7 로도 알려진 활성 A 수용체 는 인간에서 ACVR1C 유전자 에 의해 인코딩되는 단백질이다.[5] ACVR1C는 TGFB 신호 분자 계열의 I형 수용체다.[5]
ACVR1C는 노달 의 신호를 변환한다. 노달은 ACVR2B 에 바인딩된 다음 ACVR1C로 콤플렉스를 형성한다.이들은 계속 해서 R-SMADs SMAD2 또는 SMAD3를 모집한다.[6]
리간드 결합 시 타입 I는 인산화 세포질질질 SMAD 계열 전사 인자 를 수용하며, 이는 핵으로 변환되어 DNA와 직접 상호작용하거나 다른 전사 인자와 복합적으로 상호작용한다.[5]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000123612 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000026834 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b c Bondestam J, Huotari MA, Morén A, Ustinov J, Kaivo-Oja N, Kallio J, Horelli-Kuitunen N, Aaltonen J, Fujii M, Moustakas A, Ten Dijke P, Otonkoski T, Ritvos O (2001). "cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)". Cytogenet. Cell Genet . 95 (3–4): 157–62. doi :10.1159/000059339 . PMID 12063393 . S2CID 30962803 . ^ Inman GJ, Nicolás FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS (July 2002). "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7". Mol. Pharmacol . 62 (1): 65–74. doi :10.1124/mol.62.1.65 . PMID 12065756 .
외부 링크 추가 읽기 Carlsson LM, Jacobson P, Walley A, et al. (2009). "ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease" . Biochem. Biophys. Res. Commun . 382 (2): 309–14. doi :10.1016/j.bbrc.2009.03.014 . PMC 2681012 PMID 19275893 . Reissmann E, Jörnvall H, Blokzijl A, et al. (2001). "The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development" . Genes Dev . 15 (15): 2010–22. doi :10.1101/gad.201801 . PMC 312747 PMID 11485994 . Andersson O, Korach-Andre M, Reissmann E, et al. (2008). "Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity" . Proc. Natl. Acad. Sci. U.S.A . 105 (20): 7252–6. Bibcode :2008PNAS..105.7252A . doi :10.1073/pnas.0800272105 PMC 2438236 PMID 18480259 . Watanabe R, Shen ZP, Tsuda K, Yamada Y (2008). "Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells". Biochem. Biophys. Res. Commun . 377 (3): 867–72. doi :10.1016/j.bbrc.2008.10.074 . PMID 18951876 . Roberts HJ, Hu S, Qiu Q, et al. (2003). "Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta" . Biol. Reprod . 68 (5): 1719–26. doi :10.1095/biolreprod.102.013045 PMID 12606401 . Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4" . Nature . 434 (7034): 724–31. Bibcode :2005Natur.434..724H . doi :10.1038/nature03466 PMID 15815621 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Xu G, Zhong Y, Munir S, et al. (2004). "Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7" . J. Clin. Endocrinol. Metab . 89 (11): 5523–34. doi :10.1210/jc.2004-0893 PMID 15531507 . Xu G, Bernaudo S, Fu G, et al. (2008). "Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7" . Mol. Biol. Cell . 19 (11): 4968–79. doi :10.1091/mbc.E08-03-0259 . PMC 2575152 PMID 18784254 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Kim BC, van Gelder H, Kim TA, et al. (2004). "Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells" (PDF) . J. Biol. Chem . 279 (27): 28458–65. doi :10.1074/jbc.M313277200 PMID 15107418 . S2CID 29027775 . Munir S, Xu G, Wu Y, et al. (2004). "Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells" . J. Biol. Chem . 279 (30): 31277–86. doi :10.1074/jbc.M400641200 PMID 15150278 . Xu G, Zhou H, Wang Q, et al. (2006). "Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines" . Mol. Cancer Res . 4 (4): 235–46. doi :10.1158/1541-7786.MCR-05-0174 PMID 16603637 . Tsuchida K, Nakatani M, Yamakawa N, et al. (2004). "Activin isoforms signal through type I receptor serine/threonine kinase ALK7". Mol. Cell. Endocrinol . 220 (1–2): 59–65. doi :10.1016/j.mce.2004.03.009 . PMID 15196700 . S2CID 25170545 .
제1종
ALK1 (ACVRL1 )ALK2 (ACVR1A )ALK3 (BMPR1A )ALK4 (ACVR1B )ALK5 (TGFβR1 )ALK6 (BMPR1B ) 작용제: BMP (2 , 4 , 5 , 6, 7 , 8A , 8B , 15 (GDF9B)) 디보테르민알파 에프토테르민알파 GDF (5(BMP14), 6(BMP13), 7(BMP12), 9 , 15 )라도테르민 ALK7 (ACVR1C )
타입 II
TGFβR2 BMPR2 ACVR2A (ACVR2 ) 고민자: 액티비틴 (A , B , AB )BMP (2 , 4 , 5 , 6 , 7 , 8A , 8B , 15(GDF9B) 디보테르민알파 에프토테르민알파 GDF (1 , 3 , 5(BMP14), 6(BMP13), 7(BMP12), 9 , 11(BMP11), 15 )묘스타틴(GDF8) 노달 라도테르민 ACVR2B 고민자: 액티비틴 (A , B , AB )BMP (2 , 4 , 6 , 7 )디보테르민알파 에프토테르민알파 GDF (1 , 3 , 5(BMP14), 6(BMP13), 7(BMP12) 묘스타틴(GDF8) 노달 Osteogenin(BMP3, BMP3A) 라도테르민 AMHR2 (AMHR )
타입 III
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