DAPK1
DAPK1| DAPK1 | |||||||||||||||||||||||||
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| 식별자 | |||||||||||||||||||||||||
| 별칭 | DAPK1, DAPK, 사망 관련 단백질 키나아제 1, ROCO3 | ||||||||||||||||||||||||
| 외부 ID | OMIM: 600831 MGI: 1916885 HomoloGene: 3626 GeneCard: DAPK1 | ||||||||||||||||||||||||
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| 직교체 | |||||||||||||||||||||||||
| 종 | 인간 | 마우스 | |||||||||||||||||||||||
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| RefSeq(mRNA) | |||||||||||||||||||||||||
| RefSeq(단백질) | |||||||||||||||||||||||||
| 위치(UCSC) | Cr 9: 87.5 – 87.71Mb | Chr 13: 60.75 – 60.91Mb | |||||||||||||||||||||||
| PubMed 검색 | [3] | [4] | |||||||||||||||||||||||
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죽음과 관련된 단백질 키나아제 1은 인간에서 DAPK1 유전자에 의해 암호화된 효소다.[5]
함수
죽음과 관련된 단백질 키나아제 1은 감마-인터페론 유도 프로그램된 세포 사망의 긍정적인 중재자다.DAPK1은 8개의 앤키린 반복측정소와 2개의 P-루프 컨센서스 사이트를 포함하는 구조적으로 고유한 160-kD Calmodulin 종속 세린-트레오닌 키나제를 암호화한다.그것은 종양 억제제 후보작이다.[6]
멜라노사이트 세포에서는 DAPK1 유전자 발현이 MITF에 의해 조절될 수 있다.[7]
마약 타겟으로
DAPK1의 고갈은 p53-mutant 암을 가진 개인으로부터 3중 수용체 음성 유방암의 세포와 동물 모델에서 종양 세포수의 억제와 부피 증가를 초래한다.[8]이것은 실제 환자에게서 입증되지 않았다.
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000196730 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000021559 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K (Sep 1995). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively". Genomics. 29 (1): 305–7. doi:10.1006/geno.1995.1255. PMID 8530096.
- ^ "Entrez Gene: DAPK1 death-associated protein kinase 1".
- ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
- ^ Zhao J, Zhao D, Poage GM, Mazumdar A, Zhang Y, Hill JL, Hartman ZC, Savage MI, Mills GB, Brown PH (Jul 2015). "Death-associated protein kinase 1 promotes growth of p53-mutant cancers". The Journal of Clinical Investigation. 125 (7): 2707–20. doi:10.1172/JCI70805. PMC 4563671. PMID 26075823.
추가 읽기
- Deiss LP, Feinstein E, Berissi H, Cohen O, Kimchi A (Jan 1995). "Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death". Genes & Development. 9 (1): 15–30. doi:10.1101/gad.9.1.15. PMID 7828849.
- Inbal B, Shani G, Cohen O, Kissil JL, Kimchi A (Feb 2000). "Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis". Molecular and Cellular Biology. 20 (3): 1044–54. doi:10.1128/MCB.20.3.1044-1054.2000. PMC 85221. PMID 10629061.
- Jin Y, Blue EK, Dixon S, Hou L, Wysolmerski RB, Gallagher PJ (Oct 2001). "Identification of a new form of death-associated protein kinase that promotes cell survival". The Journal of Biological Chemistry. 276 (43): 39667–78. doi:10.1074/jbc.M101886200. PMC 2823794. PMID 11485996.
- Shohat G, Spivak-Kroizman T, Cohen O, Bialik S, Shani G, Berrisi H, Eisenstein M, Kimchi A (Dec 2001). "The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism". The Journal of Biological Chemistry. 276 (50): 47460–7. doi:10.1074/jbc.M105133200. PMID 11579085.
- Soria JC, Rodriguez M, Liu DD, Lee JJ, Hong WK, Mao L (Jan 2002). "Aberrant promoter methylation of multiple genes in bronchial brush samples from former cigarette smokers". Cancer Research. 62 (2): 351–5. PMID 11809677.
- Larramendy ML, Niini T, Elonen E, Nagy B, Ollila J, Vihinen M, Knuutila S (Jun 2002). "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis". Haematologica. 87 (6): 569–77. PMID 12031912.
- Hasegawa M, Nelson HH, Peters E, Ringstrom E, Posner M, Kelsey KT (Jun 2002). "Patterns of gene promoter methylation in squamous cell cancer of the head and neck". Oncogene. 21 (27): 4231–6. doi:10.1038/sj.onc.1205528. PMID 12082610.
- Jin Y, Blue EK, Dixon S, Shao Z, Gallagher PJ (Dec 2002). "A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK". The Journal of Biological Chemistry. 277 (49): 46980–6. doi:10.1074/jbc.M208585200. PMC 2824503. PMID 12351649.
- Wang WJ, Kuo JC, Yao CC, Chen RH (Oct 2002). "DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals". The Journal of Cell Biology. 159 (1): 169–79. doi:10.1083/jcb.200204050. PMC 2173490. PMID 12370243.
- Nakatsuka S, Takakuwa T, Tomita Y, Hoshida Y, Nishiu M, Yamaguchi M, Nishii K, Yang WI, Aozasa K (Jan 2003). "Hypermethylation of death-associated protein (DAP) kinase CpG island is frequent not only in B-cell but also in T- and natural killer (NK)/T-cell malignancies". Cancer Science. 94 (1): 87–91. doi:10.1111/j.1349-7006.2003.tb01357.x. PMID 12708480. S2CID 11818957.
- Tian JH, Das S, Sheng ZH (Jul 2003). "Ca2+-dependent phosphorylation of syntaxin-1A by the death-associated protein (DAP) kinase regulates its interaction with Munc18". The Journal of Biological Chemistry. 278 (28): 26265–74. doi:10.1074/jbc.M300492200. PMID 12730201.
- Gonzalez-Gomez P, Bello MJ, Alonso ME, Lomas J, Arjona D, Amiñoso C, De Campos JM, Isla A, Gutierrez M, Rey JA (2004). "Frequent death-associated protein-kinase promoter hypermethylation in brain metastases of solid tumors". Oncology Reports. 10 (4): 1031–3. doi:10.3892/or.10.4.1031. PMID 12792765.
- Matsumoto H, Nagao M, Ogawa S, Kanehiro H, Hisanaga M, Ko S, Ikeda N, Fujii H, Koyama F, Mukogawa T, Nakajima Y (2003). "Prognostic significance of death-associated protein-kinase expression in hepatocellular carcinomas". Anticancer Research. 23 (2B): 1333–41. PMID 12820391.
- Henshall DC, Araki T, Schindler CK, Shinoda S, Lan JQ, Simon RP (Sep 2003). "Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures". Journal of Neurochemistry. 86 (5): 1260–70. doi:10.1046/j.1471-4159.2003.01934.x. PMID 12911633. S2CID 21971958.
- Voso MT, Scardocci A, Guidi F, Zini G, Di Mario A, Pagano L, Hohaus S, Leone G (Jan 2004). "Aberrant methylation of DAP-kinase in therapy-related acute myeloid leukemia and myelodysplastic syndromes". Blood. 103 (2): 698–700. doi:10.1182/blood-2003-07-2249. PMID 14504087.
- Jin Y, Gallagher PJ (Dec 2003). "Antisense depletion of death-associated protein kinase promotes apoptosis". The Journal of Biological Chemistry. 278 (51): 51587–93. doi:10.1074/jbc.M309165200. PMC 2823796. PMID 14530257.
- Kim WS, Son HJ, Park JO, Song SY, Park C (Dec 2003). "Promoter methylation and down-regulation of DAPK is associated with gastric atrophy". International Journal of Molecular Medicine. 12 (6): 827–30. doi:10.3892/ijmm.12.6.827. PMID 14612952.
- Bai T, Tanaka T, Yukawa K, Maeda M, Umesaki N (Mar 2004). "Reduced expression of death-associated protein kinase in human uterine and ovarian carcinoma cells". Oncology Reports. 11 (3): 661–5. doi:10.3892/or.11.3.661. PMID 14767518.
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