AKT1

AKT1
AKT1
사용 가능한 구조
PDBOrtholog 검색: PDBe RCSB
식별자
에일리어스AKT1, AKT, CWS6, PKB, PKB-ALPA, PRKBA, RAC, RAC-ALPA, AKT 세린/트레오닌인산화효소1
외부 IDOMIM: 164730 MGI: 87986 HomoloGene: 3785 GeneCard: AKT1
맞춤법
종.인간마우스
엔트레즈

207

11651

앙상블

ENSG00000142208

ENSMUSG00000001729

유니프로트

P31749

P31750

RefSeq(mRNA)

NM_001165894
NM_009652
NM_001331107

RefSeq(단백질)

NP_001159366
NP_001318036
NP_033782

장소(UCSC)Chr 14: 104.77 ~104.8 MbChr 12: 112.62 ~112.64 Mb
PubMed 검색[3][4]
위키데이터
인간 보기/편집마우스 표시/편집

RAC(Rho 패밀리)-α-세린/트레오닌-단백질인산화효소는 사람에서 AKT1 유전자에 의해 암호화되는 효소이다.이 효소는 SH2(Src 호몰로지 2-like) 단백질 [5]도메인을 포함하는 세린/트레오닌 키나아제 AKT 서브패밀리에 속한다.일반적으로 PKB라고 불리거나 둘 다 "Akt/PKB"라고 불립니다.

기능.

세린-트레오닌 단백질 키나제 AKT1은 혈청 결핍 1차 섬유아세포 및 불멸화 섬유아세포에서 촉매적으로 비활성화된다.혈소판유래증식인자에 의해 AKT1 및 관련 AKT2가 활성화된다.활성화는 빠르고 특이적이며 AKT1의 플렉스트린 호몰로지 영역의 돌연변이에 의해 폐지된다.포스파티딜이노시톨 3-키나제를 통해 활성화되는 것으로 나타났다.발달하는 신경계에서 AKT는 성장인자 유도 신경생존의 중요한 매개체이다.생존인자는 세린/트레오닌인산화효소 AKT1을 활성화함으로써 전사비의존적인 방법으로 아포토시스를 억제할 수 있으며, 세린/트레오닌인산화효소 AKT1은 아포토시스 기계의 성분을 인산화 및 비활성화한다.Akt1이 결핍된 생쥐는 체질량의 25% 감소를 나타내며, 이는 Akt1이 IGF1 수용체를 통해 성장 촉진 신호를 전달하는 데 매우 중요하다는 것을 나타낸다.Akt1이 없는 쥐도 암에 내성이 있습니다.그들은 큰 T항원이나 뇌종양유전자에 의해 시작된 종양증식의 상당한 지연을 경험한다.이 유전자의 단핵 다형성은 프로테우스 [6][7]증후군을 일으킨다.

역사

AKT(현재는 AKT1)는 원래 변형 레트로바이러스 AKT8에서 [8]종양 유전자로 식별되었다. AKT8은 지표 밍크 세포주와의 공동 배양에 의해 AKR 생쥐에서 파생된 자발적 흉선종 세포주로부터 분리되었다.형질전환 세포 배열인 v-akt는 변형된 밍크 세포 복제에서 복제되었으며, 이러한 배열은 인간 복제 라이브러리에서 Akt1과 Akt2를 식별하는 데 사용되었다.AKT8은 Stephen Stal에 의해 Wallace P의 실험실에서 분리되었다.Rowe는 그 [9]후 Johns Hopkins Oncology Center에서 근무하는 동안 v-akt와 인간 AKT1, AKT2를 복제했다.

2011년, AKT1의 돌연변이는 코끼리 [10]인간에 영향을 미쳤을 것으로 보이는 질병인 프로테우스 증후군과 강하게 연관되어 있었다.

Akt라는 이름은 Ak 변형을 의미합니다.아크트 이름의 기원은 J. 퍼스가 자연 흉선 림프종에 걸린 생쥐에 대한 실험 연구를 수행했던 1928년으로 거슬러 올라간다.세 가지 다른 종족의 쥐를 연구했고, 그 종족은 A, R, S로 지정되었다.주식 A는 많은 암을 발생시키는 것으로 알려졌으며, 근친가족은 이후 두 번째 작은 문자(Aa, Ab, Ac 등)로 지정되었고, 따라서 생쥐의 Ak 변종이 나왔다.1936년 록펠러 연구소에서 Ak 쥐와 교배하여 AKR 쥐의 품종이 지정되었다.1977년에 변형 레트로바이러스가 AKR 마우스로부터 분리되었다.이 바이러스의 이름은 Akt-8로 변환 능력을 나타내는 "t"입니다.

상호 작용

AKT1은 다음과 상호작용하는 것으로 나타났습니다.

「 」를 참조해 주세요.

레퍼런스

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