RPS6KB2 식별자 별칭 RPS6KB2 외부 ID OMIM : 608939 MGI : 1927343 HomoloGene : 68374 GeneCard : RPS6KB2 직교체 종 인간 마우스 엔트레스 앙상블 유니프로트 RefSeq(mRNA) RefSeq(단백질) 위치(UCSC) Cr 11: 67.43 – 67.44Mb n/a PubMed 검색[2] [3] 위키다타
리보솜 단백질 S6키나제 베타-2 는 인간에게 RPS6KB2 유전자 에 의해 암호화된 효소 다.[4] [5] [6]
이 유전자는 세린/트레오닌 키나아제의 RSK(리보솜 S6 kinase ) 계열의 구성원을 인코딩한다. 이 키나아제는 두 개의 비식별적 키노아제 촉매 도메인을 포함하고 있으며 S6 리보솜 단백질과 유제품 변환 개시 인자 4B(eIF4B)를 인산화한다. S6의 인산화 작용은 단백질 합성과 세포 증식을 증가시킨다.[6]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000175634 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Saitoh M, ten Dijke P, Miyazono K, Ichijo H (Jan 1999). "Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases". Biochem Biophys Res Commun . 253 (2): 470–476. doi :10.1006/bbrc.1998.9784 . PMID 9878560 . ^ Gout I, Minami T, Hara K, Tsujishita Y, Filonenko V, Waterfield MD, Yonezawa K (Dec 1998). "Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region" . J Biol Chem . 273 (46): 30061–30064. doi :10.1074/jbc.273.46.30061 PMID 9804755 . ^ a b "Entrez Gene: RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2" . 추가 읽기 Lee-Fruman KK, Kuo CJ, Lippincott J, et al. (1999). 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Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–16903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Valovka T, Verdier F, Cramer R, et al. (2003). "Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization" . Mol. Cell. Biol . 23 (3): 852–863. doi :10.1128/MCB.23.3.852-863.2003 . PMC 140705 PMID 12529391 . Levy Y, Ronen D, Bershadsky AD, Zick Y (2003). "Sustained induction of ERK, protein kinase B, and p70 S6 kinase regulates cell spreading and formation of F-actin microspikes upon ligation of integrins by galectin-8, a mammalian lectin" . J. Biol. Chem . 278 (16): 14533–14542. doi :10.1074/jbc.M207380200 PMID 12569102 . Phin S, Kupferwasser D, Lam J, Lee-Fruman KK (2003). "Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1" . Biochem. J . 373 (Pt 2): 583–91. doi :10.1042/BJ20021794 . PMC 1223513 PMID 12713446 . Kanayasu-Toyoda T, Yamaguchi T, Oshizawa T, et al. (2003). "The role of c-Myc on granulocyte colony-stimulating factor-dependent neutrophilic proliferation and differentiation of HL-60 cells". Biochem. Pharmacol . 66 (1): 133–140. doi :10.1016/S0006-2952(03)00247-8 . PMID 12818373 . An WL, Cowburn RF, Li L, et al. (2003). "Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease" . Am. J. Pathol . 163 (2): 591–607. doi :10.1016/S0002-9440(10)63687-5 . PMC 1868198 PMID 12875979 . Lekmine F, Sassano A, Uddin S, et al. (2004). "Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein". Exp. Cell Res . 295 (1): 173–182. doi :10.1016/j.yexcr.2003.12.021 . PMID 15051500 . Raught B, Peiretti F, Gingras AC, et al. (2005). "Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases" . EMBO J . 23 (8): 1761–1769. doi :10.1038/sj.emboj.7600193 . PMC 394247 PMID 15071500 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–2127. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 .
