대형종양 억제기 키나아제 1(LATS1 )은 인간에서 LATS1 유전자 에 의해 암호화된 효소 다.[5] [6] [7]
그것은 히포 신호 경로 와 관련이 있다.[8]
이 유전자가 인코딩한 단백질은 초기 유사분열시 세포주기 조절기 CDC2키나아제 를 가진 복합체 및 유사분열기구로 국소화하는 putative serine/threonine kinase 이다. 단백질은 세포 주기 의존적인 방식으로 인산염화 되며, 후기 프로상 인산염은 은유효소 를 통해 남는다. 단백질의 N단자 부위는 CDC2를 결합하여 히스톤 H1 키나제 활성을 감소시키는 복합체를 형성하여 CDC2/사이클로인 A 의 음성 조절기 역할을 나타낸다. 또한 C-단자 키나제 영역은 자신의 N-단자 영역에 결합하여, 분자 내 결합을 통한 복잡한 형성에 대한 간섭을 통해 잠재적인 음의 규제 를 제안한다. 생화학적, 유전학적 자료는 종양 억제기 로서의 역할을 시사한다. 이것은 연성사르코마 , 난소성모세포종양 , 발암성 치료제에 대한 높은 민감도를 보여주는 녹아웃 생쥐 연구에 의해 뒷받침된다.[7]
상호작용 LATS1은 Zyxin [9] Cdk1 과 상호작용 하는 것으로 나타났다.[5]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000131023 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG00000040021 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Tao W, Zhang S, Turenchalk GS, Stewart RA, St John MA, Chen W, Xu T (February 1999). "Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity". Nat Genet . 21 (2): 177–81. doi :10.1038/5960 . PMID 9988268 . S2CID 32090556 . ^ Iida S, Hirota T, Morisaki T, Marumoto T, Hara T, Kuninaka S, Honda S, Kosai K, Kawasuji M, Pallas DC, Saya H (July 2004). "Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function" . Oncogene . 23 (31): 5266–74. doi :10.1038/sj.onc.1207623 PMID 15122335 . ^ a b "Entrez Gene: LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila)" .^ Hao Y, Chun A, Cheung K, Rashidi B, Yang X (February 2008). "Tumor suppressor LATS1 is a negative regulator of oncogene YAP" . J. Biol. Chem . 283 (9): 5496–509. doi :10.1074/jbc.M709037200 PMID 18158288 . ^ Hirota, T; Morisaki T; Nishiyama Y; Marumoto T; Tada K; Hara T; Masuko N; Inagaki M; Hatakeyama K; Saya H (May 2000). "Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor" . J. Cell Biol . 149 (5): 1073–86. doi :10.1083/jcb.149.5.1073 . ISSN 0021-9525 . PMC 2174824 PMID 10831611 .
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