호모사피엔스 종의 단백질 코딩 유전자
SNF1/AMP키나제 관련키나제 (SNARK)라고도 알려진 NUAK 계열 SNF1 유사키나제2는 인간 에서 NUAK2 유전자에 의해 인코딩되는 효소 다.[5] [6] 인간에게 결핍은 뇌 발달 을 방해하는 심각한 전방 신경관 결함 의 한 형태인 무뇌증 을 유발한다.[7]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000163545 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000009772 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs" . Genome Res . 11 (3): 422–35. doi :10.1101/gr.GR1547R . PMC 311072 PMID 11230166 . ^ "Entrez Gene: NUAK2 NUAK family, SNF1-like kinase, 2" .^ Bonnard C, Navaratnam N, Ghosh K, Chan PW, Tan TT, Pomp O, et al. (December 2020). "A loss-of-function NUAK2 mutation in humans causes anencephaly due to impaired Hippo-YAP signaling" . The Journal of Experimental Medicine . 217 (12). doi :10.1084/jem.20191561 . PMC 7953732 PMID 32845958 . 추가 읽기 Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination" . Genome Res . 10 (11): 1788–95. doi :10.1101/gr.143000 . PMC 310948 PMID 11076863 . Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Rep . 1 (3): 287–92. doi :10.1093/embo-reports/kvd058 . PMC 1083732 PMID 11256614 . Lefebvre DL, Bai Y, Shahmolky N, et al. (2001). "Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK" . Biochem. J . 355 (Pt 2): 297–305. doi :10.1042/0264-6021:3550297 . PMC 1221739 PMID 11284715 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Suzuki A, Kusakai G, Kishimoto A, et al. (2004). "Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family". Biochem. Biophys. Res. Commun . 311 (1): 156–61. doi :10.1016/j.bbrc.2003.09.184 . PMID 14575707 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Lizcano JM, Göransson O, Toth R, et al. (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1" . EMBO J . 23 (4): 833–43. doi :10.1038/sj.emboj.7600110 . PMC 381014 PMID 14976552 . Legembre P, Schickel R, Barnhart BC, Peter ME (2004). "Identification of SNF1/AMP kinase-related kinase as an NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness" . J. Biol. Chem . 279 (45): 46742–7. doi :10.1074/jbc.M404334200 PMID 15345718 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline" . Genome Res . 14 (10B): 2136–44. doi :10.1101/gr.2576704 . PMC 528930 PMID 15489336 . Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science . 307 (5715): 1621–5. Bibcode :2005Sci...307.1621B . doi :10.1126/science.1105776 . PMID 15761153 . S2CID 39457788 . Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006" . Nucleic Acids Res . 34 (Database issue): D415–8. doi :10.1093/nar/gkj139 . PMC 1347501 PMID 16381901 .
