PRKG1

PRKG1
PRKG1
Protein PRKG1 PDB 1ZXA.png
사용 가능한 구조물
PDB직교 검색: PDBe RCSB
식별자
별칭PRKG1, AAT8, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha, protein kinase, cGMP-dependent, type I, PKG1, protein kinase cGMP-dependent 1
외부 IDOMIM: 176894 MGI: 108174 HomoloGene: 55964 GeneCard: PRKG1
직교체
인간마우스
엔트레스
앙상블
유니프로트
RefSeq(mRNA)

NM_001098512
NM_006258
NM_001374781
NM_001374782

NM_001013833
NM_011160

RefSeq(단백질)

NP_001091982
NP_006249
NP_001361710
NP_001361711

NP_001013855
NP_035290

위치(UCSC)Cr 10: 50.99 – 52.3MbCr 19: 30.54 – 31.74Mb
PubMed 검색[3][4]
위키다타
인간 보기/편집마우스 보기/편집

cGMP 의존 단백질 키나아제 1, 알파 이소자임은 인간에서 PRKG1 유전자에 의해 인코딩되는 효소다.[5][6][7]

상호작용

PRKG1은 다음과 상호 작용하는 것으로 나타났다.

참조

  1. ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000185532 - 앙상블, 2017년 5월
  2. ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000052920 - 앙상블, 2017년 5월
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sandberg M, Natarajan V, Ronander I, Kalderon D, Walter U, Lohmann SM, Jahnsen T (Sep 1989). "Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat". FEBS Letters. 255 (2): 321–9. doi:10.1016/0014-5793(89)81114-7. PMID 2792381. S2CID 83233954.
  6. ^ Orstavik S, Sandberg M, Bérubé D, Natarajan V, Simard J, Walter U, Gagné R, Hansson V, Jahnsen T (April 1992). "Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10". Cytogenetics and Cell Genetics. 59 (4): 270–3. doi:10.1159/000133267. PMID 1544322.
  7. ^ "Entrez Gene: PRKG1 protein kinase, cGMP-dependent, type I".
  8. ^ Casteel DE, Zhuang S, Gudi T, Tang J, Vuica M, Desiderio S, Pilz RB (Aug 2002). "cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I". The Journal of Biological Chemistry. 277 (35): 32003–14. doi:10.1074/jbc.M112332200. PMID 12082086.
  9. ^ a b Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (Mar 2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature. 404 (6774): 197–201. Bibcode:2000Natur.404..197S. doi:10.1038/35004606. PMID 10724174. S2CID 205004996.
  10. ^ Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J (Jun 2001). "Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta". The Journal of Biological Chemistry. 276 (26): 24153–9. doi:10.1074/jbc.M101530200. PMID 11309393.
  11. ^ Tang KM, Wang GR, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME, Tang M, Wang G (Dec 2003). "Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure". Nature Medicine. 9 (12): 1506–12. doi:10.1038/nm958. PMID 14608379. S2CID 20331752.
  12. ^ Yuasa K, Michibata H, Omori K, Yanaka N (Dec 1999). "A novel interaction of cGMP-dependent protein kinase I with troponin T". The Journal of Biological Chemistry. 274 (52): 37429–34. doi:10.1074/jbc.274.52.37429. PMID 10601315.

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