ACVR2B
ACVR2B
액티빈 수용체 타입 2B는 ACVR2B [5][6][7]유전자에 의해 인간에서 암호화되는 단백질이다.ACVR2B는 액티빈 타입 2 수용체입니다.
기능.
액티빈은 구조적으로 관련된 시그널링 단백질의 변환 성장인자 베타(TGF-β) 슈퍼패밀리에 속하는 이합체 성장 및 분화인자이다.액티빈은 적어도 2개의 타입 I(I 및 IB) 수용체와 2개의 타입 II(II 및 IIB) 수용체를 포함하는 수용체 세린 키나아제들의 헤테로머 복합체를 통해 신호를 보낸다.이들 수용체는 모두 시스테인이 풍부한 영역을 가진 리간드 결합 세포외 도메인, 막간 도메인 및 세린/트레오닌 특이성을 예측한 세포질 도메인으로 구성된 막간 단백질이다.I형 수용체는 시그널링에 필수적이며, II형 수용체는 리간드 결합 및 I형 수용체의 발현에 필요하다.I형 수용체와 II형 수용체는 리간드 결합 후 안정적인 복합체를 형성하여 II형 수용체에 의한 I형 수용체의 인산화를 초래한다.Type II 수용체는 구성적으로 활성 키나아제인 것으로 간주된다.이 유전자는 A형 IIB 수용체보다 리간드에 대해 3~[7]4배 높은 친화력을 보이는 A형 IIB 수용체를 코드한다.
상호 작용
ACVR2B는 ACVR1B[8][9] 및 SYNJ2BP와 [10]상호 작용하는 것으로 나타났습니다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000114739 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000061393 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hildén K, Tuuri T, Erämaa M, Ritvos O (May 1994). "Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor". Blood. 83 (8): 2163–70. doi:10.1182/blood.V83.8.2163.2163. PMID 8161782.
- ^ Ishikawa S, Kai M, Murata Y, Tamari M, Daigo Y, Murano T, Ogawa M, Nakamura Y (July 1998). "Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene". J. Hum. Genet. 43 (2): 132–4. doi:10.1007/s100380050054. PMID 9621519.
- ^ a b "Entrez Gene: ACVR2B activin A receptor, type IIB".
- ^ Attisano L, Wrana JL, Montalvo E, Massagué J (March 1996). "Activation of signalling by the activin receptor complex". Mol. Cell. Biol. 16 (3): 1066–73. doi:10.1128/mcb.16.3.1066. PMC 231089. PMID 8622651.
- ^ De Winter JP, De Vries CJ, Van Achterberg TA, Ameerun RF, Feijen A, Sugino H, De Waele P, Huylebroeck D, Verschueren K, Van Den Eijden-Van Raaij AJ (May 1996). "Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors". Exp. Cell Res. 224 (2): 323–34. doi:10.1006/excr.1996.0142. PMID 8612709.
- ^ Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H (May 2002). "Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway". J. Biol. Chem. 277 (21): 19008–18. doi:10.1074/jbc.M112472200. PMID 11882656.
외부 링크
- UCSC Genome Browser의 인간 ACVR2B 게놈 위치 및 ACVR2B 유전자 세부 정보 페이지.
- PDB의 UniProt: Q13705(Human Activin 수용체 유형-2B)에서 PDBe-KB에 제공되는 모든 구조 정보의 개요.
- PDB for UniProt: P27040(Mouse Activin 수용체 유형-2B)에서 PDBe-KB에 제공되는 모든 구조 정보의 개요.
추가 정보
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- De Winter JP, De Vries CJ, Van Achterberg TA, Ameerun RF, Feijen A, Sugino H, De Waele P, Huylebroeck D, Verschueren K, Van Den Eijden-Van Raaij AJ (1996). "Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors". Exp. Cell Res. 224 (2): 323–34. doi:10.1006/excr.1996.0142. PMID 8612709.
- Attisano L, Wrana JL, Montalvo E, Massagué J (1996). "Activation of signalling by the activin receptor complex". Mol. Cell. Biol. 16 (3): 1066–73. doi:10.1128/MCB.16.3.1066. PMC 231089. PMID 8622651.
- Nishitoh H, Ichijo H, Kimura M, Matsumoto T, Makishima F, Yamaguchi A, Yamashita H, Enomoto S, Miyazono K (1996). "Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5". J. Biol. Chem. 271 (35): 21345–52. doi:10.1074/jbc.271.35.21345. PMID 8702914.
- Martens JW, de Winter JP, Timmerman MA, McLuskey A, van Schaik RH, Themmen AP, de Jong FH (1997). "Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells". Endocrinology. 138 (7): 2928–36. doi:10.1210/endo.138.7.5250. PMID 9202237.
- Macías-Silva M, Hoodless PA, Tang SJ, Buchwald M, Wrana JL (1998). "Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2". J. Biol. Chem. 273 (40): 25628–36. doi:10.1074/jbc.273.40.25628. PMID 9748228.
- Kosaki R, Gebbia M, Kosaki K, Lewin M, Bowers P, Towbin JA, Casey B (1999). "Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB". Am. J. Med. Genet. 82 (1): 70–6. doi:10.1002/(SICI)1096-8628(19990101)82:1<70::AID-AJMG14>3.0.CO;2-Y. PMID 9916847.
- Lee S, Alexander J, Blowes R, Ingram D, Milner AD (1999). "Determination of resonance frequency of the respiratory system in respiratory distress syndrome". Arch. Dis. Child. Fetal Neonatal Ed. 80 (3): F198-202. doi:10.1136/fn.80.3.F198. PMC 1720943. PMID 10212081.
- McPherron AC, Lawler AM, Lee SJ (1999). "Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11". Nat. Genet. 22 (3): 260–4. doi:10.1038/10320. PMID 10391213. S2CID 1172738.
- Bondestam J, Horelli-Kuitunen N, Hildén K, Ritvos O, Aaltonen J (1999). "Assignment of ACVR2 and ACVR2B the human activin receptor type II and IIB genes to chromosome bands 2q22.2-->q23.3 and 3p22 and the human follistatin gene (FST) to chromosome 5q11.2 by FISH". Cytogenet. Cell Genet. 87 (3–4): 219–20. doi:10.1159/000015429. PMID 10702675. S2CID 36135054.
- Chapman SC, Woodruff TK (2001). "Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP)". Mol. Endocrinol. 15 (4): 668–79. doi:10.1210/mend.15.4.0616. PMID 11266516.
- Wurthner JU, Frank DB, Felici A, Green HM, Cao Z, Schneider MD, McNally JG, Lechleider RJ, Roberts AB (2001). "Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone". J. Biol. Chem. 276 (22): 19495–502. doi:10.1074/jbc.M006473200. PMID 11278302.
- Parks WT, Frank DB, Huff C, Renfrew Haft C, Martin J, Meng X, de Caestecker MP, McNally JG, Reddi A, Taylor SI, Roberts AB, Wang T, Lechleider RJ (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". J. Biol. Chem. 276 (22): 19332–9. doi:10.1074/jbc.M100606200. PMID 11279102.
- Choi KC, Kang SK, Nathwani PS, Cheng KW, Auersperg N, Leung PC (2001). "Differential expression of activin/inhibin subunit and activin receptor mRNAs in normal and neoplastic ovarian surface epithelium (OSE)". Mol. Cell. Endocrinol. 174 (1–2): 99–110. doi:10.1016/S0303-7207(00)00447-0. PMID 11306176. S2CID 10648768.
- Lee SJ, McPherron AC (2001). "Regulation of myostatin activity and muscle growth". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9306–11. Bibcode:2001PNAS...98.9306L. doi:10.1073/pnas.151270098. PMC 55416. PMID 11459935.
- Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H (2002). "Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway". J. Biol. Chem. 277 (21): 19008–18. doi:10.1074/jbc.M112472200. PMID 11882656.
- Schneider-Kolsky ME, Manuelpillai U, Waldron K, Dole A, Wallace EM (2002). "The distribution of activin and activin receptors in gestational tissues across human pregnancy and during labour". Placenta. 23 (4): 294–302. doi:10.1053/plac.2002.0787. PMID 11969340.
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