PRKAG1
PRKAG1| PRKAG1 | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| 식별자 | |||||||||||||||||||||||||
| 별칭 | PRKAG1, AMPKG, 단백질 키나아제 AMP 활성 비 촉매 소단위 감마 1 | ||||||||||||||||||||||||
| 외부 ID | OMIM: 602742 MGI: 108411 HomoloGene: 99712 GeneCard: PRKAG1 | ||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| 직교체 | |||||||||||||||||||||||||
| 종 | 인간 | 마우스 | |||||||||||||||||||||||
| 엔트레스 | |||||||||||||||||||||||||
| 앙상블 | |||||||||||||||||||||||||
| 유니프로트 | |||||||||||||||||||||||||
| RefSeq(mRNA) | |||||||||||||||||||||||||
| RefSeq(단백질) | |||||||||||||||||||||||||
| 위치(UCSC) | Chr 12: 49 – 49.02Mb | Cr 15: 98.71 – 98.73Mb | |||||||||||||||||||||||
| PubMed 검색 | [3] | [4] | |||||||||||||||||||||||
| 위키다타 | |||||||||||||||||||||||||
| |||||||||||||||||||||||||
5'-AMP 활성 단백질 키나아제 서브 유닛 감마-1은 인간에서 PRKAG1 유전자에 의해 인코딩되는 효소다.[5][6][7]
함수
이 유전자에 의해 인코딩된 단백질은 AMP 활성 단백질 키나아제(AMPK)의 규제 하위단위다.AMPK는 알파 촉매 서브유닛과 비 촉매 베타 및 감마 서브유닛으로 구성된 이질트리머다.AMPK는 세포 에너지 상태를 감시하는 중요한 에너지 감지 효소다.세포 대사 스트레스에 대응하여 AMPK가 활성화되어 지방산과 콜레스테롤의 디노보 생합성 조절에 관여하는 핵심 효소인 아세틸-CoA 카복실라아제(ACC)와 베타-하이드록시 베타-메틸글루타릴-CoA 환원효소(HMGCR)가 활성화되고 불활성화된다.이 하위 장치는 AMPK의 감마 규제 하위 장치 중 하나이다.또는 구별되는 ISO 양식을 인코딩하는 분할된 대본 변형이 관찰되었다.[7]
상호작용
PRKAG1은 PRKAB2[8] 및 PRKAB1과 상호작용하는 것으로 나타났다.[8]
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000181929 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000067713 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE (January 1996). "Mammalian AMP-activated protein kinase subfamily". The Journal of Biological Chemistry. 271 (2): 611–4. doi:10.1074/jbc.271.2.611. PMID 8557660.
- ^ Gao G, Fernandez CS, Stapleton D, Auster AS, Widmer J, Dyck JR, Kemp BE, Witters LA (April 1996). "Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase". The Journal of Biological Chemistry. 271 (15): 8675–81. doi:10.1074/jbc.271.15.8675. PMID 8621499.
- ^ a b "Entrez Gene: PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit".
- ^ a b Cheung PC, Salt IP, Davies SP, Hardie DG, Carling D (March 2000). "Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding". The Biochemical Journal. 346 Pt 3 (3): 659–69. doi:10.1042/0264-6021:3460659. PMC 1220898. PMID 10698692.
추가 읽기
- Hofmann B, Nishanian P, Baldwin RL, Insixiengmay P, Nel A, Fahey JL (December 1990). "HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism". Journal of Immunology. 145 (11): 3699–705. PMID 1978848.
- Beebe SJ, Oyen O, Sandberg M, Frøysa A, Hansson V, Jahnsen T (March 1990). "Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase". Molecular Endocrinology. 4 (3): 465–75. doi:10.1210/mend-4-3-465. PMID 2342480.
- Hofmann B, Nishanian P, Nguyen T, Insixiengmay P, Fahey JL (July 1993). "Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes". Proceedings of the National Academy of Sciences of the United States of America. 90 (14): 6676–80. Bibcode:1993PNAS...90.6676H. doi:10.1073/pnas.90.14.6676. PMC 46995. PMID 7688126.
- Hofmann B, Nishanian P, Fan J, Nguyen T, Fahey JL (July 1994). "HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro". AIDS. 8 (7): 1016–7. doi:10.1097/00002030-199407000-00025. PMID 7946090.
- Woods A, Cheung PC, Smith FC, Davison MD, Scott J, Beri RK, Carling D (April 1996). "Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro". The Journal of Biological Chemistry. 271 (17): 10282–90. doi:10.1074/jbc.271.48.30517. PMID 8626596.
- Dyck JR, Gao G, Widmer J, Stapleton D, Fernandez CS, Kemp BE, Witters LA (July 1996). "Regulation of 5'-AMP-activated protein kinase activity by the noncatalytic beta and gamma subunits". The Journal of Biological Chemistry. 271 (30): 17798–803. doi:10.1074/jbc.271.30.17798. PMID 8663446.
- Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Swingler S, Gallay P, Camaur D, Song J, Abo A, Trono D (June 1997). "The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix". Journal of Virology. 71 (6): 4372–7. doi:10.1128/JVI.71.6.4372-4377.1997. PMC 191654. PMID 9151826.
- Stapleton D, Woollatt E, Mitchelhill KI, Nicholl JK, Fernandez CS, Michell BJ, Witters LA, Power DA, Sutherland GR, Kemp BE (June 1997). "AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location". FEBS Letters. 409 (3): 452–6. doi:10.1016/S0014-5793(97)00569-3. PMID 9224708. S2CID 39329574.
- Chen P, Mayne M, Power C, Nath A (September 1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". The Journal of Biological Chemistry. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMID 9278385.
- Reinton N, Haugen TB, Orstavik S, Skålhegg BS, Hansson V, Jahnsen T, Taskén K (April 1998). "The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon". Genomics. 49 (2): 290–7. doi:10.1006/geno.1998.5240. PMID 9598317.
- Zidovetzki R, Wang JL, Chen P, Jeyaseelan R, Hofman F (July 1998). "Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways". AIDS Research and Human Retroviruses. 14 (10): 825–33. doi:10.1089/aid.1998.14.825. PMID 9671211.
- Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92. doi:10.1159/000026336. PMID 9730685. S2CID 19529677.
- Cheung PC, Salt IP, Davies SP, Hardie DG, Carling D (March 2000). "Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding". The Biochemical Journal. 346 Pt 3 (3): 659–69. doi:10.1042/0264-6021:3460659. PMC 1220898. PMID 10698692.
- Hamilton SR, Stapleton D, O'Donnell JB, Kung JT, Dalal SR, Kemp BE, Witters LA (July 2001). "An activating mutation in the gamma1 subunit of the AMP-activated protein kinase". FEBS Letters. 500 (3): 163–8. doi:10.1016/S0014-5793(01)02602-3. PMID 11445078. S2CID 85248755.
- Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferré P, Birnbaum MJ, Stuck BJ, Kahn BB (April 2004). "AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus". Nature. 428 (6982): 569–74. Bibcode:2004Natur.428..569M. doi:10.1038/nature02440. PMID 15058305. S2CID 4302317.
외부 링크
- PDBe-KB는 인간 5'-AMP 활성화 단백질 키나제 하위단위 감마-1(PRKAG1)에 대해 PDB에서 이용할 수 있는 모든 구조 정보의 개요를 제공한다.
PDB 갤러리 | |
|---|---|
|
