STK4
STK4
세린/트레오닌-단백질 키나아제 4는 인간에서 STK4 유전자에 의해 암호화된 효소다.[5][6][7]
함수
이 유전자가 인코딩한 단백질은 구조적으로 이스트 스테20p(멸균 20단백질) 키나아제와 유사한 세포질 키나아제로, 스트레스로 인한 미토겐 활성 단백질 키나아제(MAPK) 계단식 상류에 작용한다.인코딩된 단백질은 미엘린 기본 단백질을 인산화시킬 수 있고 자가인산화 과정을 거친다.인코딩된 단백질의 캐스파아제 제거된 조각은 히스톤 H2B를 인지할 수 있는 것으로 나타났다.이 단백질에 의해 촉매되는 특정한 인산화효과는 세포사멸과 상관관계가 있어 이 단백질은 이 과정에서 관찰되는 염색체 응결을 유도할 가능성이 있다.[8]
상호작용
STK4는 PRKRIR와 상호작용하는 것으로 나타났다.[9]
STK4는 또한 Yap1 공동활성화기 변조를 통해 혈액학적 종양 세포 사멸을 예방하는 것으로 나타났다.[10]
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000101109 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000018209 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Taylor LK, Wang HC, Erikson RL (November 1996). "Newly identified stress-responsive protein kinases, Krs-1 and Krs-2". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10099–104. doi:10.1073/pnas.93.19.10099. PMC 38343. PMID 8816758.
- ^ Graves JD, Gotoh Y, Draves KE, Ambrose D, Han DK, Wright M, Chernoff J, Clark EA, Krebs EG (June 1998). "Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1". EMBO J. 17 (8): 2224–34. doi:10.1093/emboj/17.8.2224. PMC 1170567. PMID 9545236.
- ^ Ura S, Masuyama N, Graves JD, Gotoh Y (August 2001). "Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10148–53. doi:10.1073/pnas.181161698. PMC 56930. PMID 11517310.
- ^ "Entrez Gene: STK4 serine/threonine kinase 4".
- ^ Lin Y, Khokhlatchev A, Figeys D, Avruch J (December 2002). "Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis". J. Biol. Chem. 277 (50): 47991–8001. doi:10.1074/jbc.M202630200. PMID 12384512.
- ^ Cottini F, Hideshima T, Xu C, Sattler M, Dori M, Agnelli L, ten Hacken E, Bertilaccio MT, Antonini E, Neri A, Ponzoni M, Marcatti M, Richardson PG, Carrasco R, Kimmelman AC, Wong KK, Caligaris-Cappio F, Blandino G, Kuehl WM, Anderson KC, Tonon G (2014). "Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers" (PDF). Nat. Med. 20 (6): 599–606. doi:10.1038/nm.3562. PMC 4057660. PMID 24813251.
추가 읽기
- Choi J, Oh S, Lee D, Oh HJ, Park JY, Lee SB, Lim DS (2009). Kaeberlein M (ed.). "Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice". PLOS ONE. 4 (11): e8011. doi:10.1371/journal.pone.0008011. PMC 2776980. PMID 19956688.
- de Souza PM, Lindsay MA (2004). "Mammalian Sterile20-like kinase 1 and the regulation of apoptosis". Biochem. Soc. Trans. 32 (Pt3): 485–8. doi:10.1042/BST0320485. PMID 15157167.
- Han S, Stuart LA, Degen SJ (1991). "Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor". Biochemistry. 30 (40): 9768–80. doi:10.1021/bi00104a029. PMID 1655021.
- Gerber MJ, Drabkin HA, Firnhaber C, Miller YE, Scoggin CH, Smith DI (1988). "Regional localization of chromosome 3-specific DNA fragments by using a hybrid cell deletion mapping panel". Am. J. Hum. Genet. 43 (4): 442–51. PMC 1715492. PMID 2902784.
- Creasy CL, Chernoff J (1995). "Cloning and characterization of a human protein kinase with homology to Ste20". J. Biol. Chem. 270 (37): 21695–700. doi:10.1074/jbc.270.37.21695. PMID 7665586.
- Schultz SJ, Nigg EA (1993). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
- Creasy CL, Chernoff J (1995). "Cloning and characterization of a member of the MST subfamily of Ste20-like kinases". Gene. 167 (1–2): 303–6. doi:10.1016/0378-1119(95)00653-2. PMID 8566796.
- Creasy CL, Ambrose DM, Chernoff J (1996). "The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain". J. Biol. Chem. 271 (35): 21049–53. doi:10.1074/jbc.271.35.21049. PMID 8702870.
- Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Lee KK, Ohyama T, Yajima N, Tsubuki S, Yonehara S (2001). "MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation". J. Biol. Chem. 276 (22): 19276–85. doi:10.1074/jbc.M005109200. PMID 11278283.
- Graves JD, Draves KE, Gotoh Y, Krebs EG, Clark EA (2001). "Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis". J. Biol. Chem. 276 (18): 14909–15. doi:10.1074/jbc.M010905200. PMID 11278782.
- Lee KK, Yonehara S (2002). "Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST)". J. Biol. Chem. 277 (14): 12351–8. doi:10.1074/jbc.M108138200. PMID 11805089.
- Khokhlatchev A, Rabizadeh S, Xavier R, Nedwidek M, Chen T, Zhang XF, Seed B, Avruch J (2002). "Identification of a novel Ras-regulated proapoptotic pathway". Curr. Biol. 12 (4): 253–65. doi:10.1016/S0960-9822(02)00683-8. PMID 11864565. S2CID 14053233.
- De Souza PM, Kankaanranta H, Michael A, Barnes PJ, Giembycz MA, Lindsay MA (2002). "Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis". Blood. 99 (9): 3432–8. doi:10.1182/blood.V99.9.3432. PMID 11964314.
- Glantschnig H, Rodan GA, Reszka AA (2002). "Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation". J. Biol. Chem. 277 (45): 42987–96. doi:10.1074/jbc.M208538200. PMID 12223493.
- Lin Y, Khokhlatchev A, Figeys D, Avruch J (2002). "Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis". J. Biol. Chem. 277 (50): 47991–8001. doi:10.1074/jbc.M202630200. PMID 12384512.
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