TRIV3
TRIB3
트리블스 호몰로지 3는 인간에게 TRIV3 유전자에 의해 암호화된 단백질이다.[5][6][7]
함수
이 유전자에 의해 암호화된 단백질은 전사 인자 NF-카파B에 의해 유도되는 투입 단백질 키나아제다.NF-kappaB의 음성 조절기로 생각되는 가성질이며, TNF-와 TRAIL 유도 사멸까지 세포를 감작할 수 있다.또한, 이 단백질은 세포 생존 세린-트레오닌 키나제 AKT1을 부정적으로 조절하는 것으로 보고되었다.[7]TRIV3는 최근 뉴런 신호 전달과 연관되어 있으며, TRIV1과 TRIV2와 마찬가지로 잠재적인 신경성 약물 표적으로 간주될 수 있다.
상호작용
TRIV3는 다음과 상호 작용하는 것으로 나타났다.
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000101255 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000032715 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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- ^ Hegedus Z, Czibula A, Kiss-Toth E (Aug 2006). "Tribbles: novel regulators of cell function; evolutionary aspects". Cell Mol Life Sci. 63 (14): 1632–41. doi:10.1007/s00018-006-6007-9. PMID 16715410. S2CID 24556931.
- ^ a b "Entrez Gene: TRIB3 tribbles homolog 3 (Drosophila)".
- ^ Eyers PA, Keeshan K, Kannan N (2016). "Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease". Trends in Cell Biology. 27 (9): S0962-8924(16)30178-7. doi:10.1016/j.tcb.2016.11.002. PMC 5382568. PMID 27908682.
- ^ Foulkes DM, Byrne DP, Eyers PA (2015). "Tribbles pseudokinases: novel targets for chemical biology and drug discovery?". Biochemical Society Transactions. 43 (5): 1095–1103. doi:10.1042/BST20150109. PMID 26517930.
- ^ a b c d Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F (May 2008). "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. 20 (5): 942–8. doi:10.1016/j.cellsig.2008.01.010. PMID 18276110.
- ^ Bowers AJ, Scully S, Boylan JF (May 2003). "SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia". Oncogene. 22 (18): 2823–35. doi:10.1038/sj.onc.1206367. PMID 12743605.
- ^ Wu M, Xu LG, Zhai Z, Shu HB (July 2003). "SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription". J. Biol. Chem. 278 (29): 27072–9. doi:10.1074/jbc.M209814200. PMID 12736262.
추가 읽기
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