미토겐 활성 단백질 키나제 키나제 14 는 NF-카파-B 유도 키나제 (NIK)로도 알려져 있으며, 인간에게서 MAP3K14 유전자 에 의해 암호화된 효소 다.[5] [6]
함수 이 유전자는 미토겐 활성 단백질 키나아제 키나아제 14, NIK를 암호화하는 것으로 세린/스레오닌 단백질-키나제 다. 이 키나제는 TRAF2 에 결합되어 NF-164B 활동을 자극한다. 그것은 대안적인 NF-118B 활성화 경로의 중요한 키나아제다. 그것은 몇 개의 다른 MAPKK 키나제들과 시퀀스 유사성을 공유한다. 종양-괴사/신경성장인자(TNF /NGF ) 계열 수용체와 인터루킨-1형 I 수용체 에 공통으로 NF-bB 유도 신호 캐스케이드에 참여한다.[6]
상호작용 MAP3K14는 다음과 상호 작용하는 것으로 나타났다.
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