MAP3K11

MAP3K11
식별자
별칭	MAP3K11, MEK11, MLK-3, MLK3, PTK1, SPRK, 미토겐 활성 단백질 키나제 키나제 11
외부 ID	OMIM: 600050 MGI: 1346880 HomoloGene: 37618 GeneCard: MAP3K11
유전자 위치(인간)
쳇.	11번 염색체(인간)
끝	65,615,382 bp
유전자 위치(마우스)
쳇.	19번 염색체(쥐)
끝	5,752,893 bp
RNA 표현 패턴
	표현된 상단
	핏덩어리; ; 수근신경; ; 경골 신경; ; 간 우엽; ; 비장의; ; 뱃속; ; 좌심실; ; 오른쪽 폐;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	전이효소 활동; 뉴클레오티드 결합; 단백질 호모디메르화 활동; 미토겐 활성 단백질 키나아제 키나아제 결합; 키나제 활동; GO:0001948 단백질 결합; 동일한 단백질 결합; 미토겐 활성 단백질 키나아제 키나아제 결합; ATP 바인딩; MAP 키나제 키나제 활동; 단백질 세린/스레오닌 키나아제 활성; 단백질 키나아제 활성; 준키나제키나제키나제활동; 단백질 티로신 키나아제 활성;
셀룰러 컴포넌트	센트로놈의; 막으로 막다; 미세관 조직 센터; 미세관; 시토스켈레톤; 세포질; 세포내 해부학적 구조;
생물학적 과정	인산화; JUN kinase 활동에 대한 긍정적인 규제; 세포사망; JNK 계단식 규제; 뉴런 세포절제 과정에 대한 양성 조절; 미세관 기반 공정; 세포 인구의 증식; 단백질 자기인산화; JNK 캐스케이드; 단백질 인산화; 양세포 과정에 대한 양성 규제; MAPK 계단식 계단식; 펩티딜-티로신 인산화;
	출처:아미고 / 퀵고
직교체
	4296
	26403
	ENSG00000173327
	ENSMUSG00000004054
	Q16584
	Q80XI6
	NM_002419
	NM_022012
	NP_002410; NP_002410.1
	NP_071295
	위키다타
인간 보기/편집	마우스 보기/편집

미토겐 활성 단백질 키나아제 키나제 11은 인간에서 MAP3K11 유전자에 의해 암호화된 효소다.^[5]^[6]

함수

이 유전자가 인코딩한 단백질을 MLK3라고 하며 세린/트레오닌 키나아제 계열의 일원이다.이 키나제는 SH3 도메인과 루신 지퍼 베이직 모티브를 함유하고 있다.이 키나제는 MAPK8/JNK 키나제를 우선적으로 활성화하며, JNK 신호 경로의 양성 조절기 역할을 한다.이 키나제는 직접 인광화하여 JNK와 p38을 활성화할 수 있으며, Rho 계열 GTPases와 CDC42가 매개하는 AP1의 전사 활동에 관여하는 것으로 확인된다.^[7]^[8]

상호작용

MAP3K11은 다음과 상호 작용하는 것으로 나타났다.

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000173327 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG00000004054 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Smith CM, Ma NS, Nowak NJ, Shows TB, Gerhard DS (October 1997). "A 3-Mb Contig from D11S987 to MLK3, a Gene-Rich Region in 11q13". Genome Res. 7 (8): 835–42. doi:10.1101/gr.7.8.835. PMC 310665. PMID 9267807.
^ Ing YL, Leung IW, Heng HH, Tsui LC, Lassam NJ (June 1994). "MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain". Oncogene. 9 (6): 1745–50. PMID 8183572.
^ Kant S, Swat W, Zhang S, Zhang ZY, Neel BG, Flavell RA, Davis RJ (Oct 1, 2011). "TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway". Genes Dev. 25 (19): 2069–78. doi:10.1101/gad.17224711. PMC 3197205. PMID 21979919.
^ "Entrez Gene: MAP3K11 mitogen-activated protein kinase kinase kinase 11".
^ Barthwal MK, Sathyanarayana P, Kundu CN, Rana B, Pradeep A, Sharma C, Woodgett JR, Rana A (February 2003). "Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival". J. Biol. Chem. 278 (6): 3897–902. doi:10.1074/jbc.M211598200. PMID 12458207.
^ Nagata Ki, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A (January 1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.
^ Böck BC, Vacratsis PO, Qamirani E, Gallo KA (May 2000). "Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation". J. Biol. Chem. 275 (19): 14231–41. doi:10.1074/jbc.275.19.14231. PMID 10799501.
^ ^a ^b Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ (October 1999). "The JIP group of mitogen-activated protein kinase scaffold proteins". Mol. Cell. Biol. 19 (10): 7245–54. doi:10.1128/mcb.19.10.7245. PMC 84717. PMID 10490659.
^ Figueroa C, Tarras S, Taylor J, Vojtek AB (November 2003). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. doi:10.1074/jbc.M307357200. PMID 14504284.

추가 읽기

van de Bovenkamp M, Nottet HS, Pereira CF (2003). "Interactions of human immunodeficiency virus-1 proteins with neurons: possible role in the development of human immunodeficiency virus-1-associated dementia". Eur. J. Clin. Invest. 32 (8): 619–27. doi:10.1046/j.1365-2362.2002.01029.x. PMID 12190962. S2CID 37260932.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Gallo KA, Mark MR, Scadden DT, Wang Z, Gu Q, Godowski PJ (1994). "Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity". J. Biol. Chem. 269 (21): 15092–100. PMID 8195146.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Tanaka S, Hanafusa H (1998). "Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases". J. Biol. Chem. 273 (3): 1281–4. doi:10.1074/jbc.273.3.1281. PMID 9430657.
Leung IW, Lassam N (1999). "Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3". J. Biol. Chem. 273 (49): 32408–15. doi:10.1074/jbc.273.49.32408. PMID 9829970.
Merritt SE, Mata M, Nihalani D, Zhu C, Hu X, Holzman LB (1999). "The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate". J. Biol. Chem. 274 (15): 10195–202. doi:10.1074/jbc.274.15.10195. PMID 10187804.
Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ (2000). "The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins". Mol. Cell. Biol. 19 (10): 7245–54. doi:10.1128/mcb.19.10.7245. PMC 84717. PMID 10490659.
Kelkar N, Gupta S, Dickens M, Davis RJ (2000). "Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3". Mol. Cell. Biol. 20 (3): 1030–43. doi:10.1128/MCB.20.3.1030-1043.2000. PMC 85220. PMID 10629060.
Hehner SP, Hofmann TG, Ushmorov A, Dienz O, Wing-Lan Leung I, Lassam N, Scheidereit C, Dröge W, Schmitz ML (2000). "Mixed-Lineage Kinase 3 Delivers CD3/CD28-Derived Signals into the IκB Kinase Complex". Mol. Cell. Biol. 20 (7): 2556–68. doi:10.1128/MCB.20.7.2556-2568.2000. PMC 85472. PMID 10713178.
Böck BC, Vacratsis PO, Qamirani E, Gallo KA (2000). "Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation". J. Biol. Chem. 275 (19): 14231–41. doi:10.1074/jbc.275.19.14231. PMID 10799501.
Leung IW, Lassam N (2001). "The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation". J. Biol. Chem. 276 (3): 1961–7. doi:10.1074/jbc.M004092200. PMID 11053428.
Svensson AC, Raudsepp T, Larsson C, Di Cristofano A, Chowdhary B, La Mantia G, Rask L, Andersson G (2001). "Chromosomal distribution, localization and expression of the human endogenous retrovirus ERV9". Cytogenet. Cell Genet. 92 (1–2): 89–96. doi:10.1159/000056875. PMID 11306803. S2CID 19266745.
Zhang H, Gallo KA (2002). "Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain". J. Biol. Chem. 276 (49): 45598–603. doi:10.1074/jbc.M107176200. PMID 11590155.
Lambert JM, Karnoub AE, Graves LM, Campbell SL, Der CJ (2002). "Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation". J. Biol. Chem. 277 (7): 4770–7. doi:10.1074/jbc.M109379200. PMID 11713255.
Chadee DN, Yuasa T, Kyriakis JM (2002). "Direct Activation of Mitogen-Activated Protein Kinase Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein TRAF2". Mol. Cell. Biol. 22 (3): 737–49. doi:10.1128/MCB.22.3.737-749.2002. PMC 133545. PMID 11784851.
Vacratsis PO, Phinney BS, Gage DA, Gallo KA (2002). "Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping". Biochemistry. 41 (17): 5613–24. CiteSeerX 10.1.1.381.6228. doi:10.1021/bi016075c. PMID 11969422.

11번 염색체의 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000173327 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG00000004054 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9267807-5] Smith CM, Ma NS, Nowak NJ, Shows TB, Gerhard DS (October 1997). "A 3-Mb Contig from D11S987 to MLK3, a Gene-Rich Region in 11q13". Genome Res. 7 (8): 835–42. doi:10.1101/gr.7.8.835. PMC 310665. PMID 9267807.

[pmid8183572-6] Ing YL, Leung IW, Heng HH, Tsui LC, Lassam NJ (June 1994). "MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain". Oncogene. 9 (6): 1745–50. PMID 8183572.

[pmid21979919-7] Kant S, Swat W, Zhang S, Zhang ZY, Neel BG, Flavell RA, Davis RJ (Oct 1, 2011). "TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway". Genes Dev. 25 (19): 2069–78. doi:10.1101/gad.17224711. PMC 3197205. PMID 21979919.

[entrez-8] "Entrez Gene: MAP3K11 mitogen-activated protein kinase kinase kinase 11".

[pmid12458207-9] Barthwal MK, Sathyanarayana P, Kundu CN, Rana B, Pradeep A, Sharma C, Woodgett JR, Rana A (February 2003). "Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival". J. Biol. Chem. 278 (6): 3897–902. doi:10.1074/jbc.M211598200. PMID 12458207.

[pmid9427749-10] Nagata Ki, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A (January 1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.

[pmid10799501-11] Böck BC, Vacratsis PO, Qamirani E, Gallo KA (May 2000). "Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation". J. Biol. Chem. 275 (19): 14231–41. doi:10.1074/jbc.275.19.14231. PMID 10799501.

[pmid10490659-12] Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ (October 1999). "The JIP group of mitogen-activated protein kinase scaffold proteins". Mol. Cell. Biol. 19 (10): 7245–54. doi:10.1128/mcb.19.10.7245. PMC 84717. PMID 10490659.

[pmid14504284-13] Figueroa C, Tarras S, Taylor J, Vojtek AB (November 2003). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. doi:10.1074/jbc.M307357200. PMID 14504284.

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v t 효소
활동	활성 사이트 바인딩 사이트 촉매삼각형 옥시아니온 구멍 효소 문란성 확산제한효소 코엔자임 공동 인자 효소 촉매제
규정	알로스테릭 규제 협력성 효소억제제 효소활성화제
분류	EC 번호 효소 슈퍼 패밀리 효소군 효소 목록
키네틱스	효소동력학 이디-호프스티 도표 하네스-울프 플롯 라인위버-버크 플롯 미카엘리스-멘텐 운동학
종류들	EC1 산화효소(목록) EC2 전송(목록) EC3 하이드롤라제(목록) EC4 Lyases(목록) EC5 Isomeras(목록) EC6 리거스(목록) EC7 변환기(목록)

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MAP3K11

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