트리블스 호몰로지 2 는 TRIV2 유전자 에 의해 인간으로 부호화된 비정형 단백질 키나아제 다.[5] [6] [7] [8] TRIV2는 신호/스캐폴드 단백질의 (pseudoenzyme ) 부류의 가성질 성분으로 체외에서 거의 전정 촉매 출력을 가지고 있지 않다.[9] 표준 MAPK 경로에 신호를 보내고 면역체계의 중요한 기능을 가진 기판의 편재성을 조절하는 것으로 알려져 있다. 또한 다양한 질병, 특히 척추동물 백혈병 모델에서 연관되어 왔다.[10] TRIV1 , TRIV3 와 마찬가지로 TRIV2는 최근 잠재적 위상 약물 표적으로 고려되고 있으며 AKT pSer473 변조를 통해 암 관련 신호 전달 및 생존을 조절하는 역할을 하고 있다.[11] [12]
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